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Mashup Score: 3June 2025 - Volume 10 - Issue 3 : PAIN Reports - 14 hour(s) ago
The open home of global research and emerging pain science, PAIN Reports is an official publication of IASP. View free articles at and learn more today!
Source: journals.lww.comCategories: General Medicine News, RheumatologyTweet
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Mashup Score: 1Pain in women: bridging the gender pain gap : PAIN Reports - 20 hour(s) ago
An abstract is unavailable.
Source: journals.lww.comCategories: General Medicine News, RheumatologyTweet-
Laughey et al. argue that bridging the gender pain gap requires collaborative efforts that address female-specific biological and psychosocial dimensions of pain through evidence-based, compassionate and empathy-driven approaches. Read more in #PainReports https://t.co/aQxeddg9Ca https://t.co/x7H6ouuaXS
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Mashup Score: 7
rsen pain symptoms over time. Understanding patterns of sleep medication use is necessary for increasing appropriate treatments for sleep problems among patients with pain. Objectives: To understand the prevalence and clinical characteristics associated with sleep medication use among veterans with chronic pain. Methods: We conducted a retrospective secondary data analysis of Veterans Health Administration medical records and identified patients with a chronic pain diagnosis receiving care from October 2018 through September 2021. Using multivariate logistic regression, we examined associations between patient and clinical characteristics and sleep medication use. Results: Among all identified patients with chronic pain (N = 1,706,241), 38% carried a sleep disorder diagnosis and 19% were prescribed sleep medications. Sleep medications were prescribed in 42% of patients with insomnia and 14% of patients without active sleep problems. Insomnia, mental health comorbidities, and current or
Source: journals.lww.comCategories: General Medicine News, RheumatologyTweet-
Li et al. find that sleep medication use is common among veterans with chronic pain. Insomnia, psychiatric comorbidities, and current or recent opioid therapy are associated with a higher likelihood of sleep medication use. Learn more in #PainReports https://t.co/XbCoPPV3wS https://t.co/PWRCkppPkV
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Mashup Score: 3June 2025 - Volume 10 - Issue 3 : PAIN Reports - 5 day(s) ago
The open home of global research and emerging pain science, PAIN Reports is an official publication of IASP. View free articles at and learn more today!
Source: journals.lww.comCategories: General Medicine News, RheumatologyTweet-
The June 2025 issue of #PainReports is now available! Read the entire issue for free at https://t.co/WBveE5t1FP https://t.co/1aW1dxvK0Z
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Mashup Score: 2June 2025 - Volume 10 - Issue 3 : PAIN Reports - 8 day(s) ago
The open home of global research and emerging pain science, PAIN Reports is an official publication of IASP. View free articles at and learn more today!
Source: journals.lww.comCategories: General Medicine News, RheumatologyTweet-
The June 2025 issue of #PainReports is now available! Read the entire issue for free at https://t.co/WBveE5t1FP https://t.co/1aW1dxvK0Z
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Mashup Score: 1
t insights into epigenetics as a uniquely suited biological mechanism linking environmental stressors and pain disparities. Emerging evidence suggests that epigenetic modification of genes in pathways involved in stress dysregulation and neuroinflammation may play a central role in racial pain disparities and internalized stigma. These findings indicate that differential environmental exposure (ie, chronic stress) induces epigenetic changes (mediators) that explain pain disparities. Another putative mechanism by which differential epigenetic modifications contribute to pain disparities is epigenetic age acceleration. Emerging evidence suggests that epigenetic age acceleration mediates the relationship between lower socioeconomic status (household income, food insecurity, and neighborhood deprivation) and worse pain outcomes. Epigenetic modifications are dynamic and reversible, leaning toward pharmacological and nonpharmacological interventions. Logically, these will contribute to tailo
Source: journals.lww.comCategories: General Medicine News, RheumatologyTweet-
Temmermand et al. explore how epigenetic mechanisms contribute to chronic pain disparities among racial/ethnic groups, highlighting biopsychosocial factors that influence the pain experience. Learn more in #PainReports https://t.co/0zgQUoTzBV https://t.co/OtNkzDZSiE
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Mashup Score: 2June 2025 - Volume 10 - Issue 3 : PAIN Reports - 12 day(s) ago
The open home of global research and emerging pain science, PAIN Reports is an official publication of IASP. View free articles at and learn more today!
Source: journals.lww.comCategories: General Medicine News, RheumatologyTweet-
The June 2025 issue of #PainReports is now available! Read the entire issue for free at https://t.co/WBveE5t1FP https://t.co/1aW1dxvK0Z
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Mashup Score: 2
w persistent opioid use after hip fracture surgery in Australia. Methods: A retrospective population-based cohort study was conducted using linked administrative health data in Australia. Adults aged ≥30 years discharged from hospital after a first hip fracture surgery between July 2012 and June 2017, opioid-naïve on admission, and alive 12 months postdischarge were included. Group-based trajectory modelling was utilised to determine trajectories and rates of opioid use 12 months postdischarge. Multivariate multinomial logistic regression analysis was performed to identify risk factors for persistent opioid use. Results: Among 10,309 opioid-naïve patients who had first hip fracture surgery, 5305 (51.5%) used opioids postdischarge. Opioid users were categorised as 58.9% (3127/5305) nonpersistent, 12.6% (670/5305) fluctuating, 12.1% (641/5305) late discontinuation, and 16.3% (867/5305) persistent. Key risk factors for persistent use were total oral morphine equivalent >600 mg in first 30
Source: journals.lww.comCategories: General Medicine News, RheumatologyTweet-
Bui et al. find that approximately 1 in 6 opioid-naïve patients who survived 12 months after first hip fracture surgery were persistent opioid users at 12 months posthospital discharge. Learn more in #PainReports https://t.co/dqDfT7XCxT https://t.co/CETpx72Zdq
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Mashup Score: 6
and high (HPS). However, the reliability of these haplotypes in predicting clinical outcomes is not well investigated. We present a 40-year-old female patient with fibromyalgia. Despite extensive pharmacotherapy with 120 mg/d duloxetine, 150 mg/d pregabalin, 80 mg/d oxycodone, 2 g/d paracetamol, and 1.6 g/d ibuprofen, she suffered from severe pain. Objectives: We aim to investigate the patient’s susceptibility to analgesic therapy failure (TF) and pain sensitivity with pharmacogenotyping. Methods: PGx panel testing, including CYP2D6 and COMT rs4680, was conducted by a commercial provider. Additional genotyping of COMT rs6269, rs4633 and rs4818 was performed applying PCR, restriction fragment length polymorphism assay and sanger sequencing. Results: The patient was identified as COMT HPS/HPS diplotype carrier and CYP2D6 intermediate metabolizer. CYP2D6 is mainly responsible for the bioactivation of oxycodone into oxymorphone. Reduced CYP2D6 activity may result in a lower oxycodone activ
Source: journals.lww.comCategories: General Medicine News, RheumatologyTweet-
Bollinger et al. find that genetic predispositions in CYP2D6 and catechol-O-methyltransferase contribute to high pain sensitivity and analgesic therapy failure in a fibromyalgia patient, suggesting the need for further study. Learn more in #PainReports https://t.co/9qSqW6ily9 https://t.co/IBLonXxQZP
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Mashup Score: 0
between degeneration and pain. We hypothesize that DNA methylation, an epigenetic mechanism previously linked to discogenic LBP, is dysregulated in symptomatic vs asymptomatic IVDs. Objectives: Identify differentially methylated genes and pathways in symptomatic vs asymptomatic IVDs. Methods: Three lumbar IVDs with similar degeneration severity were tested prior to surgery by discography to identify symptomatic IVDs. Methylation analysis was performed on ∼935,000 cytosine guanine dinucleotide sites on nucleus pulposus DNA. We explored differential methylation and pathway enrichment on cytosine guanine dinucleotide sites located within the promoter regions of genes. Results: Two IVDs (L3/L4 and L4/L5) evoked pain ratings of 10/10 and 8/10, one IVD (L5/S1) scored 0/10. DNA methylation differed between symptomatic and asymptomatic IVDs. Several identified genes have roles in extracellular matrix remodeling. Other differentially methylated genes were related to immunomodulation and ion cha
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Yeater et al. find that differences in DNA methylation were identified in asymptomatic vs. symptomatic lumbar intervertebral disks with similar degeneration severity obtained from a single participant with back pain. Learn more in #PainReports https://t.co/Sne6e6sAgn https://t.co/QhG5lsjl19
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The June 2025 issue of #PainReports is now available! Read the entire issue for free at https://t.co/WBveE5t1FP https://t.co/1aW1dxvK0Z