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Mashup Score: 3Voice Assessment and Vocal Biomarkers in Heart Failure: A Systematic Review | Circulation: Heart Failure - 1 day(s) ago
Despite major advances in recent years, the timely detection and prevention of incipient congestion in patients with chronic heart failure remains challenging. Most approaches are either invasive or require the acquisition of additional hardware. Leveraging voice analysis for the purposes of diagnosing, predicting risks, and telemonitoring clinical outcomes of patients with heart failure represents a promising, cost-effective, and convenient alternative compared with hitherto deployed methods. To expand this field, close collaboration of several disciplines of medicine and computer science is an obligatory requirement. The current review aims to lay out the state-of-the-art in this quickly advancing area of research. It elucidates the foundation for voice feature extraction, describes the prospective capabilities of this evolving technology, and outlines the challenges involved in identifying vocal biomarkers both in general and in the context of heart failure.
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Mashup Score: 9
BACKGROUND: Peripheral microvascular dysfunction is a hallmark feature of both heart failure with reduced ejection fraction (HFrEF) and preserved ejection fraction (HFpEF) pathophysiology, due partly to impairments in nitric oxide signaling secondary to tetrahydrobiopterin (BH4) deficiency and oxidative stress. METHODS: Using a randomized, double-blind, placebo-controlled crossover design, this study examined the impact of enteral BH4 (10 mg/kg), an antioxidant cocktail (AOx), and coadministration of these 2 agents (BH4+AOx) on microvascular function in patients with HFrEF (n=14, 64±10 years) and HFpEF (n=19, 74±9 years). Passive limb movement was utilized to assess locomotor muscle microvascular function, and biomarkers of inflammation and oxidative damage were measured. RESULTS: Compared with placebo, the peak change in leg blood flow was not statistically different after AOx administration (HFrEF, P=0.60; HFpEF, P=0.61), but improved following BH4 (P=0.033) and BH4+AOx (P=0.019) in
Source: www.ahajournals.orgCategories: General Medicine NewsTweet-
New evidence for the efficacy of acute BH4 administration to improve peripheral microvascular function in patients with heart failure @JJRyanMD @K_Bunsawat @jaysongifford @UVRLphysiology #AHAJournals https://t.co/7vBikLx9D7 https://t.co/7eBk2Z3teJ
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Mashup Score: 7
The most common form of hereditary transthyretin cardiac amyloidosis (hATTR-CA) in the United States and the United Kingdom is the p.V142I variant. About 3% to 4% of patients with African ancestry carry this genetic predisposition to develop signs and symptoms of hATTR-CA. Nevertheless, clinical manifestations of hATTR-CA appear only late in the fifth and sixth decades of life, despite its clear genetic background. Imbalances in native protein-stabilizing and elementary breakdown cellular mechanisms are postulated as potential causes for affecting transthyretin structural integrity and myocardial fibril deposition. Noncoding variants, epigenetic and environmental factors, as well as gut microbiome derangements may serve as disease-modifying factors that feature detrimental amyloidogenic organ involvement and impact disease severity. Organ amyloid deposition varies widely among different carriers of a genetic transthyretin variant. The genotype-phenotype interdependence causes unpredict
Source: www.ahajournals.orgCategories: General Medicine NewsTweet-
Genotype-phenotype interdependence in hereditary ATTR-CA with p.V142I variant @JLGrodin @silvioaugustojr @WilsonTangMD @SVanhentenrijk #AHAJournals https://t.co/5OToiNnDc1 https://t.co/6zIGFSaOGb
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Mashup Score: 5
View all available purchase options and get full access to this article. Towbin JA, McKenna WJ, Abrams DJ, Ackerman MJ, Calkins H, Darrieux FCC, Daubert JP, de Chillou C, DePasquale EC, Desai MY, et al. 2019 HRS expert consensus statement on evaluation, risk stratification, and management of arrhythmogenic cardiomyopathy. Heart Rhythm. 2019;16:e301–e372. doi: 10.1016/j.hrthm.2019.05.007 Corrado D, Link MS, Calkins H. Arrhythmogenic right ventricular cardiomyopathy. N Engl J Med. 2017;376:1489–1490. doi:
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LVAD unloading augments GJA1-20k expression in patients with arrhythmogenic cardiomyopathy, but not in patients with NICM. @NEH_CVRTI @palatinuslab #AHAJournals https://t.co/jVKAyJnVVD https://t.co/4oy1Yf6nKB
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Mashup Score: 2Plasma Proteomics of the Fontan Circulation Reveal Signatures of Oxidative Stress and Cell Death | Circulation: Heart Failure - 11 day(s) ago
BACKGROUND: Single ventricle congenital heart disease like hypoplastic left heart syndrome with a Fontan circulation constitutes, the largest group of children hospitalized with circulation failure, experiencing an in-hospital mortality rate of 20% to 50%. We investigated the mechanisms leading to Fontan failure to identify novel therapeutic targets. METHODS: Blood was collected from patients with hypoplastic left heart syndrome post-Fontan and controls (n=6/group). Plasma microvesicles were isolated, and proteomics assessed using data-independent acquisition mass spectroscopy. Dysregulated proteins with a fold change >1.5 or ≤1.5, P<0.05, were evaluated using DAVID and Ingenuity pathway analysis. Correlation of highly dysregulated proteins was assessed with New York Heart Association class, right ventricular fractional area change, oxygen saturation, and hemoglobin. RESULTS: The age of Fontan patients versus controls was 16.0±2.1 versus 15.3±2.2. Three of six Fontan patients were in N
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Plasma Proteomics of the Fontan Circulation Reveal Signatures of Oxidative Stress and Cell Death #AHAJournals https://t.co/LJgju4NY1P https://t.co/D3qAvF3kqq
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Mashup Score: 10Ca2+ Cycling Alteration in a Porcine Model of Right Ventricular Dysfunction | Circulation: Heart Failure - 11 day(s) ago
BACKGROUND: Pulmonary hypertension is a severe disease with high mortality rates due to right ventricular (RV) failure. The molecular and cellular processes involved in RV remodeling, including Ca2+ handling, remain elusive due to the lack of relevant animal models. In this study, we aim to understand better the pathophysiological mechanisms involved in RV failure. METHODS: We used the chronic thromboembolic pulmonary hypertension (CTEPH) pig model, which leads to progressive RV hypertrophy and dysfunction. Cellular, molecular unbiased global transcriptional profiling and biochemical analyses were performed on RV cardiomyocytes from CTEPH and Sham-operated pigs. RESULTS: CTEPH pigs replicated the hemodynamics and histological changes of human CTEPH features. Transcriptome analysis in Sham and CTEPH pigs revealed molecular RV remodeling close to human patients with pulmonary arterial hypertension with decompensated RV function and notably identified changes in genes involved in Ca2+ sig
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Dynamic changes in calcium cycling drive RV dysfunction in a pre-clinical model of pulmonary hypertension https://t.co/bgPAZPQh1Q #AHAJournals @AnaMGmez4 @GrynblatJ @InsermU999 https://t.co/ZfRx4oCjxa
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Mashup Score: 5Antecedent Flu-Like Illness and Onset of Idiopathic Dilated Cardiomyopathy: The DCM Precision Medicine Study | Circulation: Heart Failure - 12 day(s) ago
BACKGROUND: Previous studies have speculated that a viral infection may act as a trigger in the development of idiopathic dilated cardiomyopathy (DCM) among individuals genetically at risk. This study aims to describe the frequency of patients with DCM who reported experiencing symptoms of flu-like illness before their DCM diagnosis and to examine if this experience modified the association between genetics and DCM. METHODS: We analyzed data from the family-based cross-sectional DCM Study conducted between 2016 and 2021. Self-reported symptoms of flu-like illness proximal to DCM diagnosis were obtained from patient interviews. Exome sequencing identified rare variants (pathogenic, likely pathogenic, or variant of uncertain significance) in DCM genes. In a case-only design, logistic mixed models were used to examine if flu-like illness modified the effect of these rare variants on DCM risk. Firth logistic regression was used to examine if flu-like illness modified the effect of each of
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Antecedent Flu-Like Illness and Onset of Idiopathic Dilated Cardiomyopathy: The DCM Precision Medicine Study @WilsonTangMD @MarkDrazner @tikuowens @PalakShahMD @DDKinnamonPhD @markhofmeyer @WilcoxHeart @eksjordan #AHAJournals https://t.co/mEfQOjD6J7 https://t.co/Q37DXqqBYP
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Mashup Score: 7
BACKGROUND: Hemodynamically guided management of patients with chronic heart failure (HF), using a remote, ambulatory pulmonary artery (PA) pressure monitor, has been shown to reduce mortality and morbidity. These improved outcomes were associated with a reduction in PA pressure. However, several pivotal questions remain unanswered: do systolic, diastolic, or mean PA pressures each predict all-cause mortality? Do PA pressures predict mortality across the ejection fraction (EF) spectrum? Do increases or decreases in PA pressure over time predict increases or decreases in mortality? METHODS: Retrospective analyses of data from CHAMPION (CardioMEMS Heart Sensor Allows Monitoring of Pressure to Improve Outcomes in NYHA Class III Heart Failure Patients; n=550), GUIDE-HF (Hemodynamic-GUIDEed management of Heart Failure; n=2358), US PAS (CardioMEMS HF System Post Approval Study; n=1200), and MEMS-HF (CardioMEMS Monitoring Study for Heart Failure; n=234) were performed, including all enrolled
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Relationship Between Remote, Ambulatory Pulmonary Artery Pressures, and All-Cause Mortality in Patients With Chronic Heart Failure @akshaydesaimd @AniqueDucharme @CEAngermann @MRMHeart1102 @mrchrtfaildoc #AHAJournals https://t.co/QMIIAN9qw5 https://t.co/IKRnmW2z79
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Mashup Score: 7
View all available purchase options and get full access to this article. File (circhf-2024-012079-s01.pdf) Videos S1–S4 File (circhf -2024-012079-s02.mp4) File (circhf-2024-012079-s03.mp4) File (circhf-2024-012079-s04.mp4) File (circhf-2024-012079-s05.mp4) Ricke-Hoch M, Pfeffer TJ, Hilfiker-Kleiner D. Peripartum cardiomyopathy: basic mechanisms and hope for new therapies. Cardiovasc Res. 2020;116:520–531. doi: 10.1093/cvr/cvz252 Goli R, Li J, Brandimarto J, Levine LD, Riis V, McAfee Q, Depalma S,
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Left ventricular function can recover after cardiogenic shock and LVAD implantation due to peripartum cardiomyopathy and TTN mutation #AHAJournals https://t.co/8FOKAmgLcz https://t.co/ezPeAF99St
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Mashup Score: 17
View all available purchase options and get full access to this article. File (circhf-2024-012506-s01.mp4) Videos S 1–S5 File (circhf-2024-012506-s02.mp4) File (circhf-2024-012506-s03.mp4) File (circhf-2024-012506-s04.mp4) File (circhf-2024-012506-s05.mp4) Reddy YNV, Frantz RP, Hassoun PM, Hemnes AR, Horn E, Leopold JA, Rischard F, Rosenzweig EB, Hill NS, Erzurum SC, et al. Clinical implications of pretest probability of HFpEF on outcomes in precapillary pulmonary hypertension. J Am Coll Cardiol. 2024;84:2
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Exercise hemodynamics with bubble injection into the pulmonary artery in evaluation of hepatopulmonary syndrome and portopulmonary hypertension in hypoxemic patients with liver disease @yreddyhf @mayoclinicCv @FadiAdelMD #AHAJournals https://t.co/ymf61vLsmd https://t.co/7kwjnEXcWj
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#Vocal biomarkers in #heart failure – a promising tool for telemonitoring, explored in our systematic review #AI #VoiceAnalysis #AHAJournals @bauser_m @DZHI_Wuerzburg https://t.co/Z9VtRGV4sS https://t.co/v56jtnH7EL