• Mashup Score: 13
    Suppression of the Prostaglandin I2–Type 1 Interferon Axis Induces Extramedullary Hematopoiesis to Promote Cardiac Repair After Myocardial Infarction | Circulation - 12 hour(s) ago

    BACKGROUND: Immune cells are closely associated with all processes of cardiac repair after myocardial infarction (MI), including the initiation, development, and resolution of inflammation. Spleen extramedullary hematopoiesis (EMH) serves as a crucial source of emergency mature blood cells that are generated through the self-renewal and differentiation of hematopoietic stem/progenitor cells (HSPCs). However, how EMH responds to MI and the role of EMH in cardiac repair after MI remains unclear. METHODS: To assess the role of spleen EMH in MI, a Tcf21CreER Scfflox/flox MI mouse model with inhibited EMH was constructed. GFP+ (green fluorescent protein) hematopoietic stem cells were sorted from eGFP (enhanced green fluorescent protein) mouse spleen by flow cytometry and injected into Tcf21CreER Scfflox/flox mice to test the sources of local inflammatory cells during MI. Using highly specific liquid chromatography–tandem mass spectrometry and single-cell RNA sequencing, we analyzed the lipi

    Source: www.ahajournals.org
    Categories: General Medicine News
    Tweet Tweets with this article
    • Profile photo of CircAHA
      CircAHA

      Splenic extramedullary hematopoiesis plays an important role in cardiac repair following MI, which may be modulated by the prostaglandin I2-type I interferon axis https://t.co/09p0Py13Y3 https://t.co/mPhsT7CyA6

  • Mashup Score: 1
    Engagement 365: Webinars - 14 hour(s) ago

    The American Heart Association Stroke Council’s Early Career Committee is hosting a series of Professional and Career Development webinars in May for early career members of the AHA. Collaborating with Industry 11AM CT on May 5, 2025 Please join us to learn more about collaborating with industry partners to foster research and innovation in clinical care. How to Write an Abstract and Review of Available Travel Awards 1PM CT on May 5, 2025 Please join us to hear tips on writing competitive abstracts and

    Source: www.ahajournals.org
    Categories: General Medicine News
    Tweet Tweets with this article
    • Profile photo of StrokeAHA_ASA
      StrokeAHA_ASA

      Engagement 365: Webinars The American Heart Association Stroke Council's Early Career Committee is hosting a series of Professional and Career Development webinars in May for early career members of the AHA. #StrokeMonth For more information, visit: https://t.co/DQzMgy1xHt https://t.co/9L0hWE4YFI

  • Mashup Score: 2
    Association Between Dietary Fiber Intake and Stroke Among US Adults: From NHANES and Mendelian Randomization Analysis | Stroke - 15 hour(s) ago

    BACKGROUND: There is debate on the link between dietary fiber intake and stroke risk. The purpose of this study was to look at how it impacts dietary fiber intake and stroke risk, as well as mortality among stroke survivors. Two-sample Mendelian randomization was also used to investigate the causal relationship. METHODS: This research examined information from 1453 patients with stroke participating in the National Health and Nutrition Examination Survey from 1999 to 2018. To assess the incidence of stroke, we conducted a survey-weighted multivariate logistic regression analysis and subgroup analysis. To evaluate the mortality associated with stroke, we used Kaplan-Meier survival analysis combined with survey-weighted Cox regression models. Using 2-sample Mendelian randomization and inverse-variance weighted method, we established a causal relationship between dietary fiber intake and stroke. The article was organized according to Strengthening the Reporting of Observational Studies in

    Source: www.ahajournals.org
    Categories: General Medicine News
    Tweet Tweets with this article
    • Profile photo of StrokeAHA_ASA
      StrokeAHA_ASA

      #STROKE: National health survey analysis shows a negative correlation between dietary fiber intake and stroke risk. Genetic prediction further demonstrates a causal relationship between dietary fiber and reduced risk of small vessel stroke. #AHAJournals https://t.co/uPNqYwVinM https://t.co/c1hPVmMVdw

  • Mashup Score: 18
    Senescent Syncytiotrophoblast Secretion During Early Onset Preeclampsia | Hypertension - 16 hour(s) ago

    BACKGROUND: Preeclampsia is a severe hypertensive disorder in pregnancy that causes preterm delivery, maternal and fetal morbidity, mortality, and life-long sequelae. Understanding the pathogenesis of preeclampsia is a critical first step toward protecting mother and child from this syndrome and increased risk of cardiovascular disease later in life. However, effective early predictive tests and therapies for preeclampsia are scarce. METHODS: To identify novel markers and signaling pathways for early onset preeclampsia, we profiled human maternal-fetal interface units (fetal villi and maternal decidua) from early onset preeclampsia and healthy controls using single-nucleus RNA sequencing combined with spatial transcriptomics. The placental syncytiotrophoblast is in direct contact with maternal blood and forms the barrier between fetal and maternal circulation. RESULTS: We identified different transcriptomic states of the endocrine syncytiotrophoblast nuclei with patterns of dysregulati

    Source: www.ahajournals.org
    Categories: General Medicine News
    Tweet Tweets with this article
    • Profile photo of HyperAHA
      HyperAHA

      RESEARCH ARTICLE: Senescent syncytiotrophoblast secretion during early-onset preeclampsia https://t.co/4vZwLeFqUm https://t.co/RKoUb1OBoB

  • Mashup Score: 11
    PCSK9 Regulates Cardiac Mitochondrial Cholesterol by Promoting TSPO Degradation | Circulation Research - 19 hour(s) ago

    BACKGROUND: Cholesterol is critical for mitochondrial membrane structure and function. Given the emergence of mitochondria as a key factor in the pathogenesis of heart failure, mitochondrial cholesterol homeostasis may be crucial for maintaining mitochondrial properties and thus cardiac function. We previously showed that CM-Pcsk9–/– mice (mice with cardiomyocyte-specific deletion of the gene encoding PCSK9 [proprotein convertase subtilisin-kexin type 9]) have impaired cardiomyocyte mitochondrial bioenergetics and heart function, paralleled by cardiomyocyte mitochondrial cholesterol accumulation and an increased number of mitochondria–endoplasmic reticulum contacts. However, the mechanisms linking PCSK9 to mitochondrial cholesterol homeostasis remain unclear. We hypothesized that PCSK9 acts on proteins involved in mitochondrial cholesterol trafficking in the heart to maintain cardiac mitochondrial function. METHODS: By performing RNA sequencing and immunoblot on hearts from CM-Pcsk9–/–

    Source: www.ahajournals.org
    Categories: General Medicine News
    Tweet Tweets with this article
    • Profile photo of CircRes
      CircRes

      Laudette & colleagues identified a role of #PCSK9 in the regulation of mitochondrial membrane #cholesterol homeostasis. Learn about a promising therapeutic approach for #HeartFailure at https://t.co/PyfZG78Q56 https://t.co/Fod8JIrcqX

Load More