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    • Mashup Score: 17
      Toxic neuropathies: a practical approach - 3 day(s) ago

      Toxic neuropathies result from exogenous substances damaging the peripheral nerves. There are numerous causes, including prescribed and recreational drugs, heavy metals, industrial agents and biological toxins. Timely recognition of these neuropathies gives better outcomes, as they usually improve or stabilise once the toxin is removed. Most toxic neuropathies are axonal, length-dependent and sensory predominant, although some have significant motor involvement or can present acutely or subacutely. Here, we outline our clinical approach and discuss the major causes of toxic neuropathy, while emphasising the clinical and neurophysiological features and the neuropathy phenotype. We also include an update on newer medications that can cause neuropathy, including immune checkpoint inhibitors and BRAF/MEK inhibitors. Data sharing not applicable as no datasets generated and/or analysed for this study.

      Source: pn.bmj.com
      Categories: General Medicine News, Nephrology
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      • Profile photo of 	MarcusVPinto
        MarcusVPinto

        Excellent recent review on toxic neuropathies (open access) https://t.co/mIqe88WngB 8/x

    • Mashup Score: 10
      Stroke as a career option for neurologists - 11 month(s) ago

      Stroke is one of the most common acute neurological disorders and a leading cause of disability worldwide. Evidence-based treatments over the last two decades have driven a revolution in the clinical management and design of stroke services. We need a highly skilled, multidisciplinary workforce that includes neurologists as core members to deliver modern stroke care. In the UK, the dedicated subspecialty training programme for stroke medicine has recently been integrated into the neurology curriculum. All neurologists will be trained to contribute to each aspect of the stroke care pathway. We discuss how training in stroke medicine is evolving for neurologists and the opportunities and challenges around practising stroke medicine in the UK and beyond. No data are available.

      Source: pn.bmj.com
      Categories: General Medicine News, Neurology
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      • Profile photo of 	AshuPJadhav
        AshuPJadhav

        Stroke as a career option for neurologists https://t.co/TumK4XtrKK

    • Mashup Score: 6
      Folic acid in women with epilepsy: prescribing advice - 12 month(s) ago

      Folate is a naturally occurring essential vitamin (vitamin B9) found in fruit, green leafy vegetables, grains and legumes.1 It is important in DNA and RNA synthesis and acts as an enzyme cofactor in the assembly of nucleic acids and amnio acids.1 Folic acid refers to a synthetic form, which is converted to folate following its consumption.1 Sufficient folate levels can only be achieved from satisfactory dietary intake or supplementation. Folate deficiency can be associated with other vitamin and mineral deficiencies. Certain public health systems (including the UK) have fortified certain foods (eg, breads, cereals) with folic acid. The aim is to reduce the risks of folate deficiency in pregnancy,2 as pregnancy is often unplanned and adherence to national folic acid supplementation guidelines is typically low. Pregnancy increases folate requirements, due to increased metabolic demands and fetal growth. Folate deficiency in pregnancy can result in anaemia in the mother, placental health

      Source: pn.bmj.com
      Categories: General Medicine News, Neurology
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      • Profile photo of 	PracticalNeurol
        PracticalNeurol

        We are treated in the epilepsy SIG to hear from Michael Kinney about folate supplementation in pregnancy https://t.co/SZ0ugZ9yti For every difficult clinical question, there’s a Practical Neurology article

    • Mashup Score: 4
      Anti-CD20 therapies in pregnancy and breast feeding: a review and ABN guidelines - 12 month(s) ago

      Neurologists increasingly use anti-CD20 therapies, including for women of childbearing age, despite these medications being unlicensed for use in pregnancy. Current evidence suggests that women can safely conceive while taking anti-CD20 therapy. Women should not be denied treatment during pregnancy when it is clinically indicated, although they should be counselled regarding live vaccinations for their infant. Women receiving regular ocrelizumab for multiple sclerosis should preferably wait 3 months before trying to conceive. There are few data around ofatumumab in pregnancy, and while there is probably a class effect across all anti-CD20 therapies, ofatumumab may need to be continued during pregnancy to maintain efficacy. We recommend that anti-CD20 therapies can be safely given while breast feeding. It is important to make time to discuss treatments with women of childbearing age to help them choose their most suitable treatment. Outcomes should be monitored in pregnancy registries.

      Source: pn.bmj.com
      Categories: General Medicine News, Neurology
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      • Profile photo of 	PracticalNeurol
        PracticalNeurol

        Always fun when our papers are directly cited at the @theABN_Info - thanks Ruth and the team for this important paper https://t.co/xHYmUzkgpL As mentioned by Simon Shields, Taunton

    • Mashup Score: 4
      Optical coherence tomography: a window to the brain? - 12 month(s) ago

      First described in 1991 and introduced into clinical practice in 1996, optical coherence tomography (OCT) now has a very extensive role in many different areas of ophthalmological practice. It is non-invasive, cheap, highly reproducible, widely available and easy to perform. OCT also has a role in managing patients with neurological disorders, particularly idiopathic intracranial hypertension. This review provides an overview of the technology underlying OCT and the information it can provide that is relevant to the practising neurologist. Particular conditions discussed include papilloedema, optic disc drusen, multiple sclerosis and neuromyelitis optica, other optic neuropathies, compression of the anterior visual pathway and various neurodegenerative conditions.

      Source: pn.bmj.com
      Categories: General Medicine News, Neurology
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      • Profile photo of 	PracticalNeurol
        PracticalNeurol

        Are you at the @theABN_Info meeting in #Edinburgh and enjoyed Luke Bennetto’s talk this morning? You might also appreciate this from recent PN archives OCT - a window to the brain https://t.co/QRAKdNFF7q

    • Mashup Score: 33
      Management of carotid atherosclerosis in stroke - 12 month(s) ago

      Internal carotid artery atherosclerosis is a major risk factor for stroke, accounting for 15–20% of ischaemic strokes. Revascularisation procedures—either carotid endarterectomy or carotid artery stenting—can reduce the risk of stroke for those with significant (>50%) luminal stenosis but particularly for those with more severe (70–99%) stenosis. However, advances in medical pharmacotherapy have implications for the relative benefit from surgery for symptomatic carotid atherosclerosis, as well as our approach to asymptomatic disease. This review considers the evidence underpinning the current medical and surgical management of symptomatic carotid atherosclerosis, the importance of factors beyond the degree of luminal stenosis, and developments in therapeutic strategies. We also discuss the importance of non-stenotic but high-risk carotid atherosclerotic plaques on the cause of stroke, and their implications for clinical practice. No data are available.

      Source: pn.bmj.com
      Categories: General Medicine News, Neurology
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      • Profile photo of 	AshuPJadhav
        AshuPJadhav

        Management of carotid atherosclerosis in stroke https://t.co/uxTmG3Odzw

    • Mashup Score: 9
      Bartonella neuroretinitis (cat-scratch disease) - 1 year(s) ago

      We report a patient with cat-scratch disease presenting with meningitis and neuroretinitis. This condition, caused by Bartonella henselae, has a worldwide distribution and is among the most common infective causes of neuroretinitis. Bartonella neuroretinitis is a rare but under-recognised mimic of optic neuritis; it should be suspected in a patient with an infective prodrome whose fundus shows optic disc oedema and a macular star. A low-positive initial serological test for Bartonella henselae does not exclude cat-scratch disease if there is high clinical suspicion, and repeat testing is recommended to look for titre rise.

      Source: pn.bmj.com
      Categories: General Medicine News, Infectious Disease
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      • Profile photo of 	MayoClinicINFD
        MayoClinicINFD

        2/ Case diagnosis: Bartonella henselae neuroretinitis Many noted the presence of the “macular star of Bartonella.” #IDBR Bartonella neuroretinitis should be suspected in a patient with optic disc oedema and a macular star. https://t.co/sm4zJFUkqa

    • Mashup Score: 32
      Management of carotid atherosclerosis in stroke - 1 year(s) ago

      Internal carotid artery atherosclerosis is a major risk factor for stroke, accounting for 15–20% of ischaemic strokes. Revascularisation procedures—either carotid endarterectomy or carotid artery stenting—can reduce the risk of stroke for those with significant (>50%) luminal stenosis but particularly for those with more severe (70–99%) stenosis. However, advances in medical pharmacotherapy have implications for the relative benefit from surgery for symptomatic carotid atherosclerosis, as well as our approach to asymptomatic disease. This review considers the evidence underpinning the current medical and surgical management of symptomatic carotid atherosclerosis, the importance of factors beyond the degree of luminal stenosis, and developments in therapeutic strategies. We also discuss the importance of non-stenotic but high-risk carotid atherosclerotic plaques on the cause of stroke, and their implications for clinical practice. No data are available.

      Source: pn.bmj.com
      Categories: General Medicine News, Neurology
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      • Profile photo of 	AshuPJadhav
        AshuPJadhav

        Management of carotid atherosclerosis in stroke https://t.co/uxTmG3Odzw

    • Mashup Score: 5
      End-of-life care - 1 year(s) ago

      My 96-year-old aunt taught me so much about end-of-life care. As doctors dealing with long-term neurological conditions, our relationships with patients over many years should enable us to be much more involved in helping them make decisions about the ceilings of treatment. No data are available.

      Source: pn.bmj.com
      Categories: General Medicine News, Neurology
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      • Profile photo of 	PracticalNeurol
        PracticalNeurol

        RT @ANitkunan: The UK patient survey run by @NeuroAlliance highlighted poor end of life care. Sharing my article https://t.co/poX3FqVcUy i…

    • Mashup Score: 0
      Incongruence in FND: time for retirement - 1 year(s) ago

      The diagnosis of functional neurological disorder (FND) has rested traditionally on two key features: inconsistency and incongruency. Inconsistency usually refers to inconsistency between movement, sensory or cognitive performance in a voluntary versus an ‘automatic’ scenario. This is the principle of Hoover’s sign of functional leg weakness, the tremor entrainment test for functional tremor and a range of cognitive tests in functional cognitive disorder. It is often helpful to share these tests with patients as they show the potential for improvement, give an insight into the ‘software’ mechanism of FND in the brain and also feed into a range of FND-specific therapies. For example, a physiotherapist might actively use distraction to promote automatic movement and discourage overlearned abnormal patterns of voluntary movement. Incongruency, on the other hand, refers to a clinical feature that is not present in other superficially similar neurological conditions, or that apparently viol

      Source: pn.bmj.com
      Categories: General Medicine News, Hem/Oncs
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      • Profile photo of 	pash22
        pash22

        Incongruence in FND: time for retirement https://t.co/f4g6G2qIZt via @jonstoneneuro

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