Various RNA viruses induce expression of small non-coding vtRNAs during infection. Stok et al. show that vtRNAs promote replication of two distinct viruses. Using mass spectrometry, they uncover the vtRNA interactome, which includes ELAVL1 and hnRNP C. VtRNAs facilitate nuclear export of these proviral factors, which enhances viral replication.
Patients don’t always present with cases that fall neatly into “mental” or “physical” boxes, writes James Downs I wanted to feel optimistic when the NHS…
Multiomics advances have led to breakthroughs in understanding human early life immunity. Adaptive memory immune cells have been detected in fetal tissue extremely early in…
Stress-induced depression-like behaviors are driven by a dynamic recurrent network involving neurons and astrocytes in the lateral habenula and norepinephrine release from neurons in the…
Copper help boost immunity, strengthen bones and support healthy skin. But you can get too much of a good thing. Learn how to get the…
Xiang and colleagues generated by gene editing isogenic induced pluripotent stem cells (iPSCs) carrying the hotspot OPA1 c.2708_2711delTTAG mutation and compared retinal organoids induced from…
The significant tissue damage imposed by intestinal helminths is controlled by a type 1 immune response. Triggered by the microbiota, gut-resident CD8+ T cells release…
Background/aim Prader-Willi syndrome (PWS) and Angelman syndrome (AS) are rare imprinting disorders caused by the aberrant expression of 15q11.2-q13 imprinted genes. Due to their rarity,…
This comparative analysis of CAR T cells, CAR NK cells, and CAR macrophages in glioma mouse models by Look et al. reveals distinct features for each cell…
Adipose stem cell-derived apoptotic bodies regulate immunity, but their disease-treating mechanism is unclear. Mao et al. discovered that these vesicles restore inflammatory balance in macrophages by…
Vitamin D could offer an alternative option over hard-to-access and burdensome cancer drugs to heighten the response of chemotherapy.
