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Mashup Score: 78Microglia activation orchestrates CXCL10-mediated CD8+ T cell recruitment to promote aging-related white matter degeneration - 2 day(s) ago
Nature Neuroscience – White matter aging leads to degenerative and inflammatory changes. Here the authors show that microglial dysfunction exacerbates glial CXCL10 expression, harmful CD8+ T cell…
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Mashup Score: 135
Nature Neuroscience – Sankowski and Prinz propose a classification framework for microglia states that considers the contextual plasticity of microglia. Their multimodal classification aligns a…
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A Perspective on a dynamic and multimodal framework to define microglial states from Roman Sankowski & Marco Prinz https://t.co/DLKUVtZFFv
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Mashup Score: 74
Nature Neuroscience – How sensory signals from both sides of the body are integrated into a single percept is not well understood. Park et al. show that callosal signaling supports the integration…
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Bilateral integration in somatosensory cortex is controlled by behavioral relevance @LabPluta @HayagreevKeri @Hyein_Park_ https://t.co/dkSdgXo5zK
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Mashup Score: 236Nature Neuroscience - Neuronal senescence in pain and aging - 9 day(s) ago
A team of explorers delve into an ancient cave where they come upon a sculpted rock column with vines. The blue and red vines represent aging and injured…
Source: www.nature.comCategories: General Medicine News, NeurologyTweet-
Our May issue is now live! https://t.co/jByYT6qEhz https://t.co/cc71O0kY9t
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Mashup Score: 109Activity-driven myelin sheath growth is mediated by mGluR5 - 9 day(s) ago
Nature Neuroscience – Employing pharmacology, genetics and all-optical approaches in zebrafish, Braaker et al. find that neuronal activity influences the growth of myelin sheaths along axons by…
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Neuronal activity influences the growth of #myelin sheaths along axons by signalling through metabotropic glutamate receptor 5 (mGluR5) on oligodendrocytes https://t.co/1GDKKMAgtZ
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Mashup Score: 85
Nature Neuroscience – The authors describe a susceptibility of the peripheral nervous system to neuronal senescence with age or injury relevant for sensory dysfunction, such as chronic pain.
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Peripheral sensory (DRG) neurons exhibit senescence in the context of aging and pain-inducing nerve injury; elimination of senescent cells improved nociceptive behaviors in nerve-injured mice @StanfordPain @TawfikLab https://t.co/XxwtA2n3xn
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Mashup Score: 85Social rank modulates methamphetamine-seeking in dominant and subordinate male rodents via distinct dopaminergic pathways - 11 day(s) ago
Nature Neuroscience – Social status mediates individual differences in methamphetamine-seeking by modulating dopaminergic pathways. In subordinate rodents, the mesolimbic pathway is stronger, and…
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Social rank modulates methamphetamine-seeking in dominant and subordinate male rodents via distinct #dopamine pathways https://t.co/uthk7LeSZr
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Mashup Score: 28MeCP2 and non-CG DNA methylation stabilize the expression of long genes that distinguish closely related neuron types - 12 day(s) ago
Nature Neuroscience – Neuron-specific DNA methylation and intragenic enhancers target the Rett syndrome protein methyl-CpG-binding protein 2 to regulate genes that delineate closely related neuron…
Source: www.nature.comCategories: General Medicine News, NeurologyTweet-
MeCP2 and non-CG DNA methylation stabilize the expression of long genes that distinguish closely related neuron types @Gabel_Lab https://t.co/7XHinYxhLQ
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Mashup Score: 32Autonomic physiological coupling of the global fMRI signal - 15 day(s) ago
Nature Neuroscience – The brain and body are necessarily connected. Here the authors show that brain blood flow and electrical activity are coupled with systemic physiological changes in the body.
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Widespread cofluctuations in the low-frequency range between resting-state global fMRI signals, EEG activity, and a host of peripheral autonomic signals spanning cardiovascular, pulmonary, exocrine and smooth muscle systems https://t.co/aZl77Ed5mT
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Mashup Score: 23Single-cell genotyping and transcriptomic profiling of mosaic focal cortical dysplasia - 24 day(s) ago
Nature Neuroscience – In this work, the authors performed a single-cell genotyping and transcriptomics analysis, revealing cell-type-specific and nonautonomous effects of mTOR pathway mutations in…
Source: www.nature.comCategories: General Medicine News, NeurologyTweet-
Single-cell genotyping and transcriptomic analysis reveals cell-type specific and non-autonomous effects of mTOR pathway mutations in mosaic focal cortical dysplasia type II (FCDII) @BaulacS @SaraBaldassari4 @KlinglerEsther @InstitutCerveau https://t.co/HzzhYlmIPC
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Microglia activation orchestrates CXCL10-mediated CD8+ T cell recruitment to promote aging-related white matter degeneration @GrohJanos @TU_Muenchen https://t.co/YoHFAKuBXJ