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Mashup Score: 2Infertility and risk of breast cancer in men: a national case–control study in England and Wales - Breast Cancer Research - 3 year(s) ago
Purpose Breast cancer is uncommon in men and its aetiology is largely unknown, reflecting the limited size of studies thus far conducted. In general, number of children fathered has been found a risk factor inconsistently, and infertility not. We therefore investigated in a case–control study, the relation of risk of breast cancer in men to infertility and number of children. Patients and methods…
Source: BioMed CentralCategories: Hem/Onc News and Journals, Latest HeadlinesTweet
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Mashup Score: 1Inhibition of stromal biglycan promotes normalization of the tumor microenvironment and enhances chemotherapeutic efficacy - 4 year(s) ago
Background Biglycan is a proteoglycan found in the extracellular matrix. We have previously shown that biglycan is secreted from tumor endothelial cells and induces tumor angiogenesis and metastasis. However, the function of stroma biglycan in breast cancer is still unclear. Methods Biglycan gene analysis and its prognostic values in human breast cancers were based on TCGA data. E0771 breast…
Source: Breast Cancer ResearchCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
Read our latest article, 'Inhibition of stromal biglycan promotes normalization of the tumor #microenvironment and enhances chemotherapeutic efficacy' https://t.co/lcEt5jhlmW #breastcancer #openaccess
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Mashup Score: 0Attenuated TGFB signalling in macrophages decreases susceptibility to DMBA-induced mammary cancer in mice - 4 year(s) ago
Background Transforming growth factor beta1 (TGFB1) is a multi-functional cytokine that regulates mammary gland development and cancer progression through endocrine, paracrine and autocrine mechanisms. TGFB1 also plays roles in tumour development and progression, and its increased expression is associated with an increased breast cancer risk. Macrophages are key target cells for TGFB1 action,…
Source: Breast Cancer ResearchCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
RT @WendyIngman: Adding another piece to the puzzle of how #breastcancer risk is determined. In mice, we show that macrophages can change their function and this affects susceptibility to mammary cancer. @RRI_Director @1sarahbernhardt https://t.co/9R6HaeGsch
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Mashup Score: 5
Background Triple-negative breast cancer (BCa) (TNBC) is a deadly form of human BCa with limited treatment options and poor prognosis. In our prior analysis of over 2200 breast cancer samples, the G protein-coupled receptor CCR5 was expressed in > 95% of TNBC samples. A humanized monoclonal antibody to CCR5 (leronlimab), used in the treatment of HIV-infected patients, has shown minimal side…
Source: Breast Cancer ResearchCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
'The safety profile of leronlimab, together with strong preclinical evidence to both prevent and reduce established breast cancer metastasis herein, suggests studies of clinical efficacy may be warranted.' Read for free #OA: https://t.co/e37jbJmsHF #leronlimab #metastasis
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Mashup Score: 0Circulating tumor DNA as a dynamic biomarker of response to palbociclib and fulvestrant in metastatic breast cancer patients - 4 year(s) ago
Background Following the PALOMA-3 study results, the combination of palbociclib, a CDK4/6 inhibitor, with fulvestrant, a selective estrogen receptor degrader, has become a standard therapy in women with estrogen receptor-positive (ER+) HER2-negative (HER2−) metastatic breast cancer (MBC). Palbociclib has been shown to increase the progression-free survival (PFS) overall but no predictive…
Source: Breast Cancer ResearchCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
Read our latest article 'Circulating tumor DNA as a dynamic biomarker of response to palbociclib and fulvestrant in metastatic breast cancer patients' https://t.co/Hv7GoVJAHG #breastcancer #Precisionmedicine
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Mashup Score: 0Quantitative stain-free imaging and digital profiling of collagen structure reveal diverse survival of triple negative breast cancer patients - 4 year(s) ago
Background Stromal and collagen biology has a significant impact on tumorigenesis and metastasis. Collagen is a major structural extracellular matrix component in breast cancer, but its role in cancer progression is the subject of historical debate. Collagen may represent a protective layer that prevents cancer cell migration, while increased stromal collagen has been demonstrated to facilitate…
Source: Breast Cancer ResearchCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
Quantitative stain-free imaging and digital profiling of collagen structure reveal diverse survival of triple negative breast cancer patients Read for free! https://t.co/7qRlM9R6YJ #Quantitativeimaging #Stroma #BreastCancer https://t.co/WC6kq3qDnc
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Mashup Score: 1COVID-19 in breast cancer patients: a cohort at the Institut Curie hospitals in the Paris area - 4 year(s) ago
Background Cancer patients have been reported to be at higher risk of COVID-19 complications and deaths. We report the characteristics and outcome of patients diagnosed with COVID-19 during breast cancer treatment at Institut Curie hospitals (ICH, Paris area, France). Methods An IRB-approved prospective registry was set up at ICH on March 13, 2020, for all breast cancer patients with COVID-19…
Source: Breast Cancer ResearchCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
Here is Breast Cancer Research's most cited paper from 2020. It suggests that the #COVIDー19 mortality rate in breast cancer patients depends more on #comorbidities than prior radiation therapy or current anti-cancer treatment. https://t.co/13KINhXMIT #breastcancer
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Mashup Score: 0Effects of neoadjuvant chemotherapy on the contralateral non-tumor-bearing breast assessed by diffuse optical tomography - 4 year(s) ago
Background The purpose of this study is to evaluate whether the changes in optically derived parameters acquired with a diffuse optical tomography breast imager system (DOTBIS) in the contralateral non-tumor-bearing breast in patients administered neoadjuvant chemotherapy (NAC) for breast cancer are associated with pathologic complete response (pCR). Methods In this retrospective evaluation of…
Source: Breast Cancer ResearchCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
Check out the latest article from Breast Cancer Research! Effects of neoadjuvant chemotherapy on the contralateral non-tumor-bearing breast assessed by diffuse optical tomography Read here: https://t.co/tXezsdRSRG #ContralateralBreastCancer #BreastCancer #OpenAccess
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Infertility and risk of breast cancer in men: a national case–control study in England and Wales Read the study here: https://t.co/XkXVFQjfdR Read the news article here: https://t.co/JXxP5Y0We6 #BreastCancer #MaleBreastCancer #Infertility @BioMedCentral