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    • Mashup Score: 10
      Daratumumab or Active Monitoring for High-Risk Smoldering Multiple Myeloma | NEJM - 7 month(s) ago

      Daratumumab, an anti-CD38 monoclonal antibody, has been approved for the treatment of multiple myeloma. Data are needed regarding the use of daratumumab for high-risk smoldering multiple myeloma, a…

      Source: www.nejm.org
      Categories: General Medicine News, Hem/Oncs
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        Daratumumab or Active Monitoring for High-Risk Smoldering Multiple Myeloma | New England Journal of Medicine https://t.co/8LytRpPtLE

    • Mashup Score: 1
      Elías Campo: "El coneixement generat durant vint anys de recerca al projecte del genoma de la leucèmia comença a arribar al pacient" - 7 month(s) ago

      Director de l’IDIBAPS i catedràtic de la UB

      Source: www.ara.cat
      Categories: General Medicine News, Hem/Oncs
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        https://t.co/uqe1KNBt81

    • Mashup Score: 35
      CD70 CAR T cells secreting an anti-CD33/anti-CD3 dual targeting antibody overcome antigen heterogeneity in AML - 8 month(s) ago

      Key Points. CD70 targeted CAR-T cells secreting a CD33 T-cell engaging antibody molecule eradicate CD33 or CD70 deficient AML

      Source: ashpublications.org
      Categories: General Medicine News, Hem/Oncs
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        CD70 CAR T cells secreting an anti-CD33/anti-CD3 dual targeting antibody overcome antigen heterogeneity in AML https://t.co/6S2iUd0xwc

    • Mashup Score: 34
      Obecabtagene Autoleucel in Adults with B-Cell Acute Lymphoblastic Leukemia | NEJM - 8 month(s) ago

      Obecabtagene autoleucel (obe-cel) is an autologous 41BB-ζ anti-CD19 chimeric antigen receptor (CAR) T-cell therapy which uses an intermediate-affinity CAR to reduce toxic effects and improve persis…

      Source: www.nejm.org
      Categories: General Medicine News, Hem/Oncs
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        Obecabtagene Autoleucel in Adults with B-Cell Acute Lymphoblastic Leukemia | New England Journal of Medicine https://t.co/cIR8LJQ3UH

    • Mashup Score: 18
      Paper: Lack of Benefit of Autologous Hematopoietic Cell Transplantation (auto-HCT) in Mantle Cell Lymphoma (MCL) Patients (pts) in First Complete Remission (CR) with Undetectable Minimal Residual Disease (uMRD): Initial Report from the ECOG-ACRIN EA4151 Phase 3 Randomized Trial - 8 month(s) ago

      Program: Late-breaking Abstracts Session: Late-Breaking Abstracts Session Hematology Disease Topics & Pathways: Research, Clinical trials, Lymphomas, Non-Hodgkin lymphoma, Clinical Research, B Cell lymphoma, Diseases, Lymphoid Malignancies 1 Medica l College of Wisconsin, Milwaukee, WI 2 Dana-Farber Cancer Institute / ECOG-ACRIN Biostatistics, Bostin, MA 3 Fred Hutchinson Cancer Center, University of Washington, Seattle, WA 4 Emory University / Winship Cancer Institute, Atlanta, GA 5 University of

      Source: ash.confex.com
      Categories: General Medicine News, Hem/Oncs
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        Stop ASCT for MCL...another evidence https://t.co/MyUi5Xj692

    • Mashup Score: 18
      Paper: Lack of Benefit of Autologous Hematopoietic Cell Transplantation (auto-HCT) in Mantle Cell Lymphoma (MCL) Patients (pts) in First Complete Remission (CR) with Undetectable Minimal Residual Disease (uMRD): Initial Report from the ECOG-ACRIN EA4151 Phase 3 Randomized Trial - 8 month(s) ago

      Program: Late-breaking Abstracts Session: Late-Breaking Abstracts Session Hematology Disease Topics & Pathways: Research, Clinical trials, Lymphomas, Non-Hodgkin lymphoma, Clinical Research, B Cell lymphoma, Diseases, Lymphoid Malignancies 1 Medica l College of Wisconsin, Milwaukee, WI 2 Dana-Farber Cancer Institute / ECOG-ACRIN Biostatistics, Bostin, MA 3 Fred Hutchinson Cancer Center, University of Washington, Seattle, WA 4 Emory University / Winship Cancer Institute, Atlanta, GA 5 University of

      Source: ash.confex.com
      Categories: General Medicine News, Hem/Oncs
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      • Profile photo of 	albertomussetti
        albertomussetti

        Stop ASCT for MCL...another evidence https://t.co/MyUi5Xj692

    • Mashup Score: 3
      Attitudes and perceptions of medical researchers towards the use of artificial intelligence chatbots in the scientific process: an international cross-sectional survey - PubMed - 8 month(s) ago

      Chatbots are artificial intelligence (AI) programs designed to simulate conversations with humans that present opportunities and challenges in scientific research. Despite growing clarity from publishing organisations on the use of AI chatbots, researchers’ perceptions remain less understood. In thi …

      Source: pubmed.ncbi.nlm.nih.gov
      Categories: General Medicine News, Hem/Oncs
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        Attitudes and perceptions of medical researchers towards the use of artificial intelligence chatbots in the scienti… https://t.co/ZKkOkkahiY

    • Mashup Score: 2
      Science in the Age of AI | AI for Science Forum - 8 month(s) ago

      Eric Topol, Executive Vice President, Scripps Research, leads a conversation with:- Alison Noble, Oxford University Technikos Professor of Biomedical Enginee…

      Source: www.youtube.com
      Categories: General Medicine News, Hem/Oncs
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        Science in the Age of AI | AI for Science Forum https://t.co/hgUJ6nFBIK via @YouTube

    • Mashup Score: 35
      CD70 CAR T cells secreting an anti-CD33/anti-CD3 dual targeting antibody overcome antigen heterogeneity in AML - 8 month(s) ago

      Key Points. CD70 targeted CAR-T cells secreting a CD33 T-cell engaging antibody molecule eradicate CD33 or CD70 deficient AML

      Source: ashpublications.org
      Categories: General Medicine News, Hem/Oncs
      Tweet Tweets with this article
      • Profile photo of 	albertomussetti
        albertomussetti

        CD70 CAR T cells secreting an anti-CD33/anti-CD3 dual targeting antibody overcome antigen heterogeneity in AML https://t.co/6S2iUd0xwc

    • Mashup Score: 14
      Abstract 4114505: Cardiovascular Adverse Events After Anti-BCMA CAR-T (Ide-Cel and Cilta-Cel) for Relapsed/ Refractory Multiple Myeloma | Circulation - 8 month(s) ago

      Introduction: Idecabtagene vicleucel (Ide-Cel) and ciltacabtagene autoleucel (Cilta-cel) are novel CAR-T therapies targeting B-cell maturation antigen (BCMA) and approved for relapsed and refractory multiple myeloma (RRMM). While cardiovascular adverse events (CVAE) are relatively common with CD-19 CAR-T, the incidence of CVAE in the real-world setting for anti-BCMA CAR-T in RRMM is largely unknown. This study aims to determine the incidence of CVAE and its associated risk factors in patients treated with ide-cel and cilta-cel. Method: This single-center retrospective cohort study evaluated RRMM patients treated with ide-cel and cilta-cel from May 2021 to December 2023. We assessed baseline cardiac and oncologic characteristics and clinical outcomes post-CAR-T. Cytokine release syndrome (CRS) and immune cell-associated neurologic syndrome (ICANS) grading followed ASTCT consensus guidelines. Result: A total of 164 RRMM patients treated with ide-cel (N=109) or cilta-cel (N=55) with at le

      Source: www.ahajournals.org
      Categories: General Medicine News, Hem/Oncs
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        Abstract 4114505: Cardiovascular Adverse Events After Anti-BCMA CAR-T (Ide-Cel and Cilta-Cel) for Relapsed/ Refractory Multiple Myeloma | Circulation https://t.co/HyijqhuEoO

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    Dr.Alberto Mussetti

    @albertomussetti

    Hematologist from Milan, working @ Institut Català d'Oncologia Science & Health News #hematology #transplant #lymphoma #immunotherapy #CAR #digitalmedicine

    ASCO 2025

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