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Mashup Score: 14Low-coverage whole genome sequencing of low-grade dysplasia strongly predicts advanced neoplasia risk in ulcerative colitis - 6 hour(s) ago
Background The risk of developing advanced neoplasia (AN; colorectal cancer and/or high-grade dysplasia) in ulcerative colitis (UC) patients with a low-grade dysplasia (LGD) lesion is variable and difficult to predict. This is a major challenge for effective clinical management. Objective We aimed to provide accurate AN risk stratification in UC patients with LGD. We hypothesised that the pattern and burden of somatic genomic copy number alterations (CNAs) in LGD lesions could predict future AN risk. Design We performed a retrospective multicentre validated case–control study using n=270 LGD samples from n=122 patients with UC. Patients were designated progressors (n=40) if they had a diagnosis of AN in the ~5 years following LGD diagnosis or non-progressors (n=82) if they remained AN-free during follow-up. DNA was extracted from the baseline LGD lesion, low-coverage whole genome sequencing performed and data processed to detect CNAs. Survival analysis was used to evaluate CNAs as pred
Source: gut.bmj.comCategories: General Medicine News, GastroenterologyTweet
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Mashup Score: 12In vitro microbiota model recapitulates and predicts individualised sensitivity to dietary emulsifier - 6 hour(s) ago
Background Non-absorbed dietary emulsifiers, including carboxymethylcellulose (CMC), directly disturb intestinal microbiota, thereby promoting chronic intestinal inflammation in mice. A randomised controlled-feeding study (Functional Research on Emulsifiers in Humans, FRESH) found that CMC also detrimentally impacts intestinal microbiota in some, but not all, healthy individuals. Objectives This study aimed to establish an approach for predicting an individual’s sensitivity to dietary emulsifiers via their baseline microbiota. Design We evaluated the ability of an in vitro microbiota model (MiniBioReactor Arrray, MBRA) to reproduce and predict an individual donor’s sensitivity to emulsifiers. Metagenomes were analysed to identify signatures of emulsifier sensitivity. Results Exposure of human microbiotas, maintained in the MBRA, to CMC recapitulated the differential CMC sensitivity previously observed in FRESH subjects. Furthermore, select FRESH control subjects (ie, not fed CMC) had m
Source: gut.bmj.comCategories: General Medicine News, GastroenterologyTweet-
#GUTImage from the paper by Rytter @HeloiseRytter et al on "In vitro microbiota model recapitulates and predicts individualised sensitivity to dietary emulsifier" via https://t.co/TvnuuS7Grf @BenoitChassaing @institutpasteur @Inserm #Emulsifiers #Diet https://t.co/RitzYFTsAh
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Mashup Score: 4Colorectal cancer incidence after the first surveillance colonoscopy and the need for ongoing surveillance: a retrospective, cohort analysis - 6 hour(s) ago
Background Recommendations for the first postpolypectomy surveillance colonoscopy (SC1), based on stratifying postpolypectomy colorectal cancer (CRC) risk, are well established. Limited data inform recommendations for surveillance beyond SC1. Objective We investigated which patient groups need surveillance beyond SC1. Design Retrospective analysis of patients who underwent colonoscopy with polypectomy at 17 UK hospitals, mostly from 2000 to 2010, and had ≥1 surveillance colonoscopies. Cancer and death data were collected through 2017. We examined patients in groups defined by risk at baseline and SC1, applying risk definitions from the 2020 UK postpolypectomy surveillance guidelines: ‘low risk, low risk’ (LR-LR), ‘high risk, low risk’ (HR-LR), ‘low risk, high risk’ (LR-HR) and ‘high risk, high risk’ (HR-HR). We examined CRC incidence after SC1, censoring at any second surveillance colonoscopy (SC2), and after SC2 through end of follow-up. We compared incidence with general population i
Source: gut.bmj.comCategories: General Medicine News, GastroenterologyTweet-
#GUTOnline paper by Robbins et al entitled "Colorectal cancer incidence after the first surveillance colonoscopy and the need for ongoing surveillance: a retrospective, cohort analysis" via https://t.co/o3BnKJuvFp @DrAmandaJCross @CSPRG_Imperial @andymveitch #ColorectalCancer https://t.co/ZItDJ68Suu
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Mashup Score: 4Stressed hepatocyte sustains alcohol-associated hepatitis progression by producing leukocyte cell-derived chemotaxin 2 - 6 hour(s) ago
Background Neutrophil infiltration and hepatocyte damage are indispensable hallmarks in alcohol-associated hepatitis (AH), yet the underlying crosstalk between neutrophils and hepatocytes and its role in AH pathogenesis remain unclear. Objective We investigate the regulatory role of leucocyte cell-derived chemotaxin 2 (LECT2) in hepatocyte–neutrophil interaction and its impact on AH progression. Design We used bulk and single-cell RNA sequencing to identify hepatocyte-secreted factors targeting neutrophils. We analysed serum and liver samples from AH patients and employed genetically modified mice alongside in vitro studies. Results RNA-sequencing analysis identified several neutrophil chemokines that are elevated in hepatocytes from AH patients, including LECT2 whose role in AH remains largely unknown. AH patients exhibited increased levels of LECT2 in hepatocytes, positively correlating with the severity of AH. Ethanol-fed mice also exhibited elevated liver LECT2, which was abolished
Source: gut.bmj.comCategories: General Medicine News, GastroenterologyTweet-
Read the #GUTOnline paper by Xu et al entitled "Stressed hepatocyte sustains alcohol-associated hepatitis progression by producing leukocyte cell-derived chemotaxin 2" via https://t.co/1Dm0YzCkPI @wanghualiver #Hepatitis #Alcohol https://t.co/8M0j7GP0iI
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Mashup Score: 0A randomized controlled trial of a through-the-scope stiffening wire to increase the depth of insertion during double-balloon enteroscopy - 10 hour(s) ago
We investigated whether use of a stiffening wire increased insertion depth during double-balloon enteroscopy (DBE).
Source: www.giejournal.orgCategories: General Medicine News, GastroenterologyTweet-
Online now in GIE’s Articles in Press: "A randomized controlled trial of a through-the-scope stiffening wire to increase the depth of insertion during double-balloon enteroscopy" by Meagan Archer et al. https://t.co/4iLWncrPHa #GITwitter https://t.co/Tm7rhZ8eVi
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Mashup Score: 3EUS-guided intervention in surgically altered anatomy to remove large biliary stone - 11 hour(s) ago
Post written by Azimudin Haja, MD, DM, Aniruddha Pratap Singh, DM, and Sundeep Lakhtakia, MD, DM, from AIG Hospitals, Hyderabad, India. Our case highlights the challenges faced in managing a patien…
Source: endoscopedia.comCategories: General Medicine News, GastroenterologyTweet-
Just posted on the official blog: "EUS-guided intervention in surgically altered anatomy to remove large biliary stone" by Azimudin Haja, Aniruddha Pratap Singh, and Sundeep Lakhtakia https://t.co/zxXhFZ8OgY https://t.co/tWap1tEW5v
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Mashup Score: 49SAGES Membership Information - Join SAGES Today - 14 hour(s) ago
There are many benefits of membership in SAGES, including discounts for meeting registration, eligibility in our basic and advanced resident courses and more
Source: www.sages.orgCategories: General Medicine News, GastroenterologyTweet-
We know you want to join SAGES, and be one of the 7,000+ cool kids worldwide. We accept new members on a quarterly basis. To be approved in Fall 2023 review, please apply by November 10. More information and application here: https://t.co/djxCWpQ9MQ
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Mashup Score: 28
The abstract submission site opened on Monday, March 3, 2025. The submission deadline is Monday, June 2, 2025, at 11:59pm (ET). The American College of Gastroenterology invites all members and non-members, including physicians, advanced practice providers, non-physicians, gastroenterologists, internists, surgeons, hepatologists, radiologists, pediatricians, fellows-in-training, and medical students to submit abstracts for presentation at the ACG 2025 Annual Meeting at the Phoenix Convention Center in
Source: www.abstractscorecard.comCategories: General Medicine News, GastroenterologyTweet-
The call for abstracts for 🌵#ACG2025 is open! Submit your high-quality, clinically relevant GI and hepatology abstracts to be considered for oral and poster presentation. Submissions due Monday, June 2! ➡️https://t.co/qtM0iVFtvz @AmyOxentenkoMD @IBD_Afzali https://t.co/yOxZeGIopx
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Mashup Score: 2Researchers estimate thousands visited ED for adverse events related to semaglutide - 19 hour(s) ago
An estimated 24,499 people visited the ED for adverse events related to semaglutide in the 2 years after its approval for weight loss, according to a study published in Annals of Internal Medicine.The most common symptoms included nausea, vomiting and diarrhea, which had been previously documented in clinical trials. However, researchers also discovered that 16% of ED visits involved
Source: www.healio.comCategories: General Medicine News, GastroenterologyTweet-
An estimated 25,000 people visited the ED for GI symptoms or hypoglycemia related to #semaglutide in the 2 years following its approval for #weightloss. https://t.co/GdAr47zr5l
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Mashup Score: 1
Histotripsy is a novel, ultrasound-based ablative technique that was recently approved by the Food and Drug Administration for hepatic targets. It has several promising additional theoretical applications that need to be further investigated. Its basis as a nonthermal cavitational technology presents a unique advantage over existing thermal ablation techniques in maximizing local effects while minimizing adjacent tissue destruction. This review discusses the technical basis and current preclinical and clinical data surrounding histotripsy.
Source: www.jogs.orgCategories: General Medicine News, GastroenterologyTweet-
Check out one of our most read articles this month, "Histotripsy – hype or hope? Review of innovation and future implications" https://t.co/cWqXntG6v0
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#GUTImages from the paper by Al Bakir et al on "Low-coverage whole genome sequencing of low-grade dysplasia strongly predicts advanced neoplasia risk in ulcerative colitis" via https://t.co/kO4tEAzEFB @DrPipDunne @trevoragraham @yosoykit #UC #LGD https://t.co/rh7ceZ0hCc