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The role of the hypothalamic–pituitary–thyroid axis in thyroid cancer
The hypothalamic–pituitary–thyroid axis plays a crucial role in the pathogenesis, diagnosis, risk stratification, effectiveness of radioiodine therapy, and treatment response evaluation in epithelial thyroid cancer.…
Follow-up after successful treatment for developmental dysplasia of the hip using a Pavlik harness | Bone & Joint
Follow-up after successful treatment for developmental dysplasia of the hip using a Pavlik harness
Redefining Clinically Significant Blood Loss in Complex… : Spine
e suboptimal in predicting adverse events (AEs). Materials and Methods. Adults undergoing complex ASD surgery were included. Estimated blood loss (EBL) was extracted for investigation,…
Phthalate exposure from plastics and cardiovascular disease: global estimates of attributable mortality and years life lost
Plastics pose a significant risk to increased cardiovascular mortality, disproportionately impacting regions which have developing plastic production sectors. The findings underscore the need for urgent…
Increased Operative Time yet Enhanced Accuracy in Computer-Assisted vs. Mechanical Hip Resurfacing Arthroplasty: An Updated Systematic Review and Meta-Analysis
Hip resurfacing arthroplasty (HRA) is considered a highly complex procedure, requiring advanced specialization and training beyond that of conventional total hip arthroplasty (THA). With the…
Adding Dexmedetomidne to Intra-articular Local Anesthetics Results in Prolonged Analgesia After Knee Arthroscopy: A Systematic Review and Meta-analysis
To assess the efficacy and safety of dexmedetomidine as an adjuvant to intra-articular (IA) injections of local anesthetics (LA) in adult patients undergoing knee arthroscopy.
Long‐Term Health Consequences of SARS‐CoV‐2‐ Trigger for Still Disease in Adults
Still disease is a rare inflammatory disorder often triggered by infections or malignancies, with SARS-CoV-2 as a possible factor. This paper explores a 56-year-old patient…
Targeting the intracellular immune checkpoint CISH with CRISPR-Cas9-edited T cells in patients with metastatic colorectal cancer: a first-in-human, single-centre, phase 1 trial
These results support the safety and potential antitumour activity of inhibiting the immune checkpoint CISH through the administration of neoantigen-reactive CISH-knockout TILs, with implications for…
Targeting the intracellular immune checkpoint CISH with CRISPR-Cas9-edited T cells in patients with metastatic colorectal cancer: a first-in-human, single-centre, phase 1 trial
These results support the safety and potential antitumour activity of inhibiting the immune checkpoint CISH through the administration of neoantigen-reactive CISH-knockout TILs, with implications for…
‘First of a new class’: FDA approves upadacitinib to treat giant cell arteritis
The FDA has approved the Janus kinase inhibitor upadacitinib for the treatment of giant cell arteritis in adults, the first such approval in the disease…
