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Mashup Score: 2Non-Redundant Roles of Topoisomerase 2α and 2β in the Cytosolic Replication of Vaccinia Virus - 2 month(s) ago
Vaccinia virus is a large enveloped DNA virus, which, like all poxviruses, replicates in the cytoplasm of infected cells. Vaccinia was historically thought to encode all the proteins required for its replication. However, recent findings have shown that nuclear host proteins are redirected to the cytoplasm to facilitate viral replication. Among these, topoisomerase 2α (TOP2A) and 2β (TOP2B), which mediate nuclear transcription, DNA replication, and chromosome segregation are the most abundant host proteins associated with nascent viral genomes. Here, we investigate the mechanisms driving TOP2A and TOP2B cytoplasmic translocation and their role in viral replication. We found that early viral protein synthesis induces the cytosolic relocalization of both isoforms, which are subsequently recruited to viral factories by an interaction of their C-terminal domains with the viral ligase, A50. TOP2A promotes replication by interacting with the vaccinia DNA replication machinery. In contrast, T
Source: www.biorxiv.orgCategories: General Medicine News, Infectious DiseaseTweet
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Mashup Score: 0Chlamydia trachomatis impairs T cell priming by inducing dendritic cell death | Infection and Immunity - 6 month(s) ago
Chlamydia trachomatis is an obligate intracellular bacterium that infects epithelial cells. It is the most common bacterial sexually transmitted disease in the United States, with an estimated 2.86 million infections occurring annually (1). While curable with antibiotics, infections are often asymptomatic and thus left untreated (2). This can lead to serious sequelae in women, such as pelvic inflammatory disease, infertility, and ectopic pregnancy (3). Despite the high public health burden of C. trachomatis, a vaccine to prevent this disease is not available. A better understanding of the immune response to C. trachomatis is, therefore, crucial to the development of an effective vaccine (4).
Source: journals.asm.orgCategories: General Medicine News, Infectious DiseaseTweet
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Mashup Score: 1The antimicrobial properties of exogenous copper in human synovial fluid against Staphylococcus aureus - AI Talks with Bone & Joint - 6 month(s) ago
Listen to Simon and Amy discuss the paper ‘The antimicrobial properties of exogenous copper in human synovial fluid against Staphylococcus aureus’ published in the November 2024 issue of Bone & Joint Research.Click here to read the paper.Find out as soon as the next episode is live by following us on Twitter, Instagram, LinkedIn, Tik Tok or Facebook!
Source: www.buzzsprout.comCategories: General Medicine News, RheumatologyTweet
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Mashup Score: 17
Transphyseal hematogenous osteomyelitis (THO) is a common infectious condition, being present in 25% of patients with hematogenous osteomyelitis. A large proportion of pediatric hematogenous osteomyelitis infections can spread through the…
Source: www.jbjs.orgCategories: General Medicine News, RheumatologyTweet
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Mashup Score: 5New mouse models offer valuable window into COVID-19 infection - 10 month(s) ago
Scientists at La Jolla Institute for Immunology (LJI) have developed six lines of humanized mice that can serve as valuable models for studying human cases of COVID-19.
Source: medicalxpress.comCategories: General Medicine News, General HCPsTweet
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Mashup Score: 5
Key Points. Nonhematopoietic cells express MHC II in response to IFN-γ from Chlamydia-specific CD4+ Th1 cells.Chlamydia-specific CD4+ Th1 cells express Gra
Source: journals.aai.orgCategories: General Medicine News, Infectious DiseaseTweet
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Mashup Score: 7Controlled human infection study paves the way to improving vaccines and therapeutics development - 1 year(s) ago
A first-of-its-kind study led by the University of Oxford has successfully investigated human immunity against COVID-19 in people who already have antibodies against it. The results suggest that previous …
Source: medicalxpress.comCategories: General Medicine News, General HCPsTweet
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Mashup Score: 3Culture-Negative Osteomyelitis: Is it Haemophilus haemolyticus? - 1 year(s) ago
A 50-year-old woman presented to our emergency department with severe intractable atraumatic right hip pain. She was admitted to the hospital, and an orthopaedic consult was requested. She does have…
Source: www.jbjs.orgCategories: General Medicine News, RheumatologyTweet
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Mashup Score: 9Peptide-triggered IL-12 and IFN-γ mediated immune response in CD4+ T-cells against Leishmania donovani infection - 1 year(s) ago
Leishmania donovani are intracellular, human blood parasites that cause visceral leishmaniasis or kala-azar. Cell-penetrating peptides (CPPs) have been shown to modulate intracellular processes and cargo delivery, whereas host defense peptides (HDPs) promote proliferation of both naïve and antigen activated CD4+ T-
Source: pubs.rsc.orgCategories: General Medicine News, Infectious DiseaseTweet
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Mashup Score: 18
Roughly 1 in 2 wearers of ventricular assist devices are diagnosed with an infection. The reason for this is the thick cable for the power supply. ETH Zurich researchers have now developed a solution …
Source: medicalxpress.comCategories: General Medicine News, General NewsTweet
🤩 Joining #Infection: Pathogens, Hosts, and Microbiomes? 🎙️ Dr. Michael Way from @TheCrick will be presenting tomorrow on ultrastructural imaging of poxvirus exit from infected cells! Their latest work: https://t.co/gYoGFKeYOR Check out the program: https://t.co/YOVF10O8Tt https://t.co/3TUJt3wXtq