Inflammatory bowel disease (IBD) has emerged as a global disease, affecting individuals of every ethnicity and age groups worldwide.1 It is broadly accepted that the greatest single risk factor for the development of IBD is having an affected family member.2 First-degree relatives (FDRs) of patients with IBD have approximately a 10-fold greater likelihood of developing the disease than the general population. Despite the fact that numerous studies have been deliciated towards exploring the possible determinants that participated in, the underlying aetiology remains elusive. Amalgamation of both genetic predisposition and environmental exposures have been widely recognised as the predominant factors that instigate and drive the course of IBD. On this basis, they may also serve as contributing factors to the familial occurrence of IBD. Given that the family members of patients with IBD represent a specific population enduring this dual challenges over an extended period, it is of great c