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Mashup Score: 23Metabolic Dysfunction and Alcohol-related Liver Disease (MetALD): Position statement by an expert panel on alcohol-related liver disease - 7 month(s) ago
This position statement explores the intricate relationship between alcohol intake and metabolic dysfunction in the context of the 2023 nomenclature for steatotic liver disease (SLD). Recent and lifetime alcohol use should be accurately assessed in all patients with SLD to facilitate classification of alcohol use in grams of alcohol per week. Alcohol biomarkers (i.e., phosphatidylethanol), use of validated questionnaires (i.e. AUDIT-C), and collateral information from friends and relatives could help facilitate differentiation between alcohol-related liver disease (ALD) per se and liver disease with both metabolic and alcohol-related components (MetALD).
Source: www.journal-of-hepatology.euCategories: General Medicine News, GastroenterologyTweet
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Mashup Score: 0
Nature – An investigation into the relationship between network structure and gut microbiome composition among people living in 18 isolated Honduras villages reveals that strain-sharing can be…
Source: www.nature.comCategories: General Medicine News, GastroenterologyTweet-
#GastroEdPick Gut microbiome strain-sharing within isolated village social networks @Nature https://t.co/76SQvMZl7m
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Mashup Score: 20Fecal microbial load is a major determinant of gut microbiome variation and a confounder for disease associations - 7 month(s) ago
A machine-learning approach enables the quantification of microbial load (microbial cells per gram) in fecal samples based on the relative microbiome profile. The predicted microbial load emerged as a major determinant of microbiome variation, confounding various disease-microbe associations across more than 34,000 global metagenomes.
Source: www.cell.comCategories: General Medicine News, GastroenterologyTweet-
#GastroEdPick Fecal microbial load is a major determinant of gut microbiome variation and a confounder for disease associations @CellPressNews https://t.co/P4IoRJxGSE
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Mashup Score: 6Risk of Hepatocellular Carcinoma in Asian Patients with Primary Biliary Cholangitis: A Nationwide and Hospital Cohort Study - 8 month(s) ago
Large-scale studies on the association between primary biliary cholangitis (PBC) and hepatocellular carcinoma (HCC) in Asians are scarce. This study aimed to evaluate the incidence of HCC and its risk factors in a nationwide cohort.
Source: www.jhep-reports.euCategories: General Medicine News, GastroenterologyTweet-
#GastroEdPick Risk of Hepatocellular Carcinoma in Asian Patients with Primary Biliary Cholangitis: A Nationwide and Hospital Cohort Study @JHEP_Reports https://t.co/g4BwZ2WJsU
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Mashup Score: 3Integrative multiomic analysis identifies distinct molecular subtypes of NAFLD in a Chinese population - 8 month(s) ago
Integrative multiomic analysis identifies three molecular subtypes of NAFLD associated with distinct clinical risks.
Source: www.science.orgCategories: General Medicine News, GastroenterologyTweet-
#GastroEdPick Integrative multiomic analysis identifies distinct molecular subtypes of NAFLD in a Chinese population @ScienceTM https://t.co/zFoxKtuIeF
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Mashup Score: 4A blood-based biomarker panel for non-invasive diagnosis of metabolic dysfunction-associated steatohepatitis - 8 month(s) ago
Zhang et al. developed a robust blood-based biomarker panel for the non-invasive diagnosis of metabolic dysfunction-associated steatohepatitis (MASH) among patients with metabolic dysfunction-associated steatotic liver disease (MASLD). The biomarker panel demonstrates high diagnostic accuracy with three independent cohort validations in Asia and America, thus highlighting its potential clinical utility in non-invasive diagnosis of MASH in MASLD patients.
Source: www.cell.comCategories: General Medicine News, GastroenterologyTweet-
#GastroEdPick A blood-based biomarker panel for non-invasive diagnosis of metabolic dysfunction-associated steatohepatitis @Cell_Metabolism https://t.co/bcwQxmj4KI
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Mashup Score: 4Structure-guided discovery of bile acid derivatives for treating liver diseases without causing itch - 8 month(s) ago
Bile acids (BAs) are 3-sulfonated to improve their potency to activate MRGPRX4 (hX4), the G-protein-coupled receptor for cholestatic itch. The cryo-EM structure of hX4 binding with a bile acid-derived agonist highlights the importance of the 3-hydroxyl group in BAs to activate hX4 and helps develop the lead compound, C7, as a promising candidate for treating liver diseases without the unwanted side effect of itch.
Source: www.cell.comCategories: General Medicine News, GastroenterologyTweet-
#GastroEdPick Structure-guided discovery of bile acid derivatives for treating liver diseases without causing itch @CellPressNews https://t.co/08wuJpaAco
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Mashup Score: 3A human gut Faecalibacterium prausnitzii fatty acid amide hydrolase - 8 month(s) ago
Undernutrition in Bangladeshi children is associated with disruption of postnatal gut microbiota assembly; compared with standard therapy, a microbiota-directed complementary food (MDCF) substantially improved their ponderal and linear growth. Here, we …
Source: www.science.orgCategories: General Medicine News, GastroenterologyTweet-
#GastroEdPick A human gut Faecalibacterium prausnitzii fatty acid amide hydrolase @ScienceMagazine https://t.co/JSBkrqP5Q4
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Mashup Score: 2A longitudinal single-cell atlas of anti-tumour necrosis factor treatment in inflammatory bowel disease - 8 month(s) ago
Nature Immunology – In this Resource, Buckley and colleagues profile patients with Crohn’s disease and ulcerative colitis before and after adalimumab therapy. Specific pretreatment…
Source: www.nature.comCategories: General Medicine News, GastroenterologyTweet-
#GastroEdPick A longitudinal single-cell atlas of anti-tumour necrosis factor treatment in inflammatory bowel disease @NatImmunol https://t.co/yavcJdvP79
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Mashup Score: 2
Nature – Health effects of dietary restriction are uncoupled from longevity.
Source: www.nature.comCategories: General Medicine News, GastroenterologyTweet-
#GastroEdPick Dietary restriction impacts health and lifespan of genetically diverse mice @Nature https://t.co/gylj5GsGMl
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#GastroEdPick Metabolic Dysfunction and Alcohol-related Liver Disease (MetALD): Position statement by an expert panel on alcohol-related liver disease @JHepatology https://t.co/LnUDdzewFh