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Mashup Score: 0In memoriam – Professor Allan R Glanville, past president ISHLT - 13 hour(s) ago
On the 22nd of December 2024 Professor Allan Glanville passed away in Sydney Australia from stage 4 melanoma aged 71 years, survived by his wife, 2 children, 3 grandchildren and extended family. His was an important life indeed not just through his mentoring and training of healthcare professionals but also the countless lives of Australian patients and their families he positively impacted through his lifelong dedication to organ transplantation. Professor Glanville was a wise, gentle and benevolent man, affable with a terrific sense of humor and intensely interested in people.
Source: www.jhltonline.orgCategories: General Medicine NewsTweet
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Mashup Score: 6Risk assessment models and survival in pulmonary arterial hypertension: a SPAHR analysis - 2 day(s) ago
Multicomponent improvement (MCI) is a novel endpoint for predicting survival in patients with pulmonary arterial hypertension (PAH), included in the sotatercept clinical program. For the first time, we investigated the prognostic value of MCI, ESC/ERS 4-strata risk (4SR) assessment, and the non-invasive French risk stratification score (FRS), for predicting survival in PAH patients in Sweden. All risk prediction models are based on three parameters: WHO-FC (World Health Organization Functional Class), NT-proBNP, and 6MWD (6-minute walk distance).
Source: www.jhltonline.orgCategories: General Medicine NewsTweet-
From the Swedish Pulmonary Arterial Hypertension Registry (SPAHR), three simplified risk assessment models were found to have prognostic relevance for transplant-free survival in patients with pulmonary arterial hypertension. @ClaraHjalm93291 #PAH 🔗: https://t.co/rbeQYYeEii
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Mashup Score: 15Lung transplantation and bone health: A narrative review - 5 day(s) ago
Bone health after lung transplantation has not been comprehensively reviewed in over two decades. This narrative review summarizes available literature on bone health in the context of lung transplantation, including epidemiology, presentation and post-operative management. Osteoporosis is reported in approximately 30-50% of lung transplant candidates, largely due to disease-related impact on bone and lifestyle, and corticosteroid-related effects during end-stage lung disease (interstitial lung diseases, chronic obstructive pulmonary disease, and historically cystic fibrosis).
Source: www.jhltonline.orgCategories: General Medicine NewsTweet-
New review on bone disease after #lungtransplant highlights significant osteoporosis burden and evidence gaps on pharmacotherapy regimens & patient outcomes. Formal management guidelines are urgently needed. @AnnaRzepka8, @AngelaMCheung 🔗: https://t.co/8oBNeXf3k0
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Mashup Score: 12Increases in donor/recipient predicted heart mass ratios do not result in large donor right ventricles - 6 day(s) ago
Pulmonary hypertension puts strain on the right ventricle (RV), leading to the widespread practice of oversizing donor hearts to mitigate complications. However, contemporary evidence for this practice is neutral. We studied the relationship between donor-recipient predicted heart mass (D/R PHM) ratios and increases in donor left ventricle (LV) and RV mass. We also studied the relationship between predicted D/R PHM ratios and predicted D/R LV mass difference and RV mass difference. We find that increases in D/R PHM ratios result in minimal change in donor RV mass as well as minimal change in predicted D/R RV mass difference.
Source: www.jhltonline.orgCategories: General Medicine NewsTweet-
Despite our desires, increases in PHM does not appear to result in larger right ventricles 🔗: https://t.co/BeaCTP7MxK
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Mashup Score: 2Heart failure related cardiogenic shock: An ISHLT consensus conference content summary - 8 day(s) ago
In recent years, there have been significant advancements in the understanding, risk-stratification, and treatment of cardiogenic shock (CS). Despite improved pharmacologic and device-based therapies for CS, short-term mortality remains as high as 50%. Most recent efforts in research have focused on CS related to acute myocardial infarction, even though heart failure related CS (HF-CS) accounts for >50% of CS cases. There is a paucity of high-quality evidence to support standardized clinical practices in approach to HF-CS.
Source: www.jhltonline.orgCategories: General Medicine NewsTweet-
It’s time to tear down healthcare silos and respond to the shock syndrome. Educate to enable staff awareness, treat is fast (like a STEMI or stroke) and develop care paths to enable FAST interventions. https://t.co/hnNQKoraBg
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Mashup Score: 8The prognostic value of single and repeated ≥10% FEV1 declines for chronic lung allograft dysfunction - 9 day(s) ago
There is a paucity of data reporting the positive and negative predictive values (PPV, NPV) of acute declines in lung function on chronic lung allograft dysfunction (CLAD). We sought to define the predictive ability of single or repeated forced expiratory volume in the first second (FEV1) declines for at least 3 weeks on the development of CLAD or death by 1-year. We analyzed 340 subjects with at least 3 years of follow-up data from two lung transplant centers. A single ≥10% FEV1 decline had a PPV of 35% and NPV of 63%, and a repeated ≥10% FEV1 decline for at least 3 weeks had a PPV of 44% and NPV of 65%.
Source: www.jhltonline.orgCategories: General Medicine NewsTweet-
In a large cohort, the estimated probability for developing CLAD one-year following the onset of a single ≥10% FEV1 decline or repeated ≥10% FEV1 decline for at least 3 weeks was 27% and 40%, respectively. @uwpccm, @kathyjramos, @RamseyHachem 🔗: https://t.co/9ytw7D0EiS
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Mashup Score: 3
The psychosocial evaluation plays an essential role in the multidisciplinary assessment of pediatric patients for thoracic organ transplantation or ventricular assist device (VAD) placement. However, there is considerable practice variation with regard to the content and process of the evaluation, with no known recent published guidelines. Furthermore, the pediatric evaluation necessarily differs from the adult evaluation in a number of substantive ways, including caregiver roles and decision-making.
Source: www.jhltonline.orgCategories: General Medicine NewsTweet-
International, multidisciplinary group of pediatric transplant professionals: @ISHLT, @ActionNetworkHQ, @PHTSociety, @IptaPedsTx, and @transplantfams, Framework of VAD/Transplant Psychosocial Evaluation @lefkowitz_debra #PedsTx 🔗: https://t.co/jS6B3uvH8w
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Mashup Score: 7
ECMO plays an integral part in all phases of lung transplantation: pre-operative bridging, intra-operative management and in some cases, post-operative recovery. This manuscript from Zhou et. al. utilized the UNOS database to study practice patterns in the use of ECMO as a bridge to lung transplant specifically in patients who are not mechanically ventilated.1 Our increased global experience in ECMO for acute respiratory failure, especially in the recent setting of COVID-19, has changed the narrative around ECMO and in many ways encouraged its use and standardized protocols.
Source: www.jhltonline.orgCategories: General Medicine NewsTweet-
@AliceLiZhou @ErrolBushMD 🧵 This #editorial from @SSaddoughi examines how #ECMO has had an expanded role in all aspects on lung transplant with an important focus on pre-operative bridge to lung transplant. 🫁 🔗: https://t.co/ZzbSmW9bvs
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Mashup Score: 3Cracking the code of BOS and RAS - 15 day(s) ago
Despite improvement in patient care over the past decades, allograft failure remains the leading cause of long-term morbidity and mortality after lung transplantation. Bronchiolitis obliterans syndrome (BOS) was first identified as the main clinical manifestation of progressive and persistent allograft failure.1 A second type of rejection called restrictive allograft syndrome (RAS) was subsequently described as distinct from BOS in its pathophysiological presentation. These different transplant complications were then regrouped under the umbrella term of chronic lung allograft dysfunction (CLAD).
Source: www.jhltonline.orgCategories: General Medicine NewsTweet-
🧵 Exciting #editorial regarding tissue profiling on different #CLAD phenotypes. 🔗: https://t.co/aGFhG9dLTO
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Mashup Score: 10High-dimensional tissue profiling of immune cell responses in chronic lung allograft dysfunction - 16 day(s) ago
The immunological drivers of chronic lung allograft dysfunction (CLAD), the major barrier to long-term survival after lung transplantation, are poorly understood at a tissue level. Tissue imaging using mass spectrometry with laser ablation of regions of interest offers single-cell resolution of distinct immune cell populations and their spatial relationships and may improve our understanding of CLAD pathophysiology.
Source: www.jhltonline.orgCategories: General Medicine NewsTweet-
Fibrotic remodelling in chronic lung allograft dysfunction is associated with γδ T cells in bronchiolitis obliterans syndrome and intermediate M2 macrophages and Th1 cells in restrictive allograft syndrome. 🫁 🔗: https://t.co/qQ1kusb0V7
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At #ISHLT2025, Past President Professor Glanville was posthumously recognized with the Lifetime Achievement Award to honor his dedication, leadership, and service that was critical to advancing the care of patients with advanced heart & lung disease. 🔗: https://t.co/KNB3WQ1kzi