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Mashup Score: 33
As the global population ages, the incidence of cancer among older adults is expected to rise significantly, with projections indicating that by 2030, nearly 70 % of all cancer cases will be in individuals aged 65 and older. While decision-making on dosing of anticancer agents is a straightforward process in young and fit patients with cancer – considering the evidence from randomized clinical trials (RCTs) with cure or overall survival (OS) benefit as goal – in older adults it proves more challenging.
Source: www.geriatriconcology.netCategories: General Medicine NewsTweet
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Mashup Score: 11Representation of older adults in registrational trials associated with therapeutic approvals in diffuse large B-cell lymphoma - 4 day(s) ago
Diffuse large B-cell lymphoma (DLBCL) is the most common non-Hodgkin lymphoma (NHL) subtype, accounting for 30–40 % of all NHL cases globally [1]. DLBCL is predominantly a disease of older adults with a median age at diagnosis of 67 years. About a third of patients with newly diagnosed DLBCL are over 75 years of age [1]. Age over 60 is included in the International Prognostic Index as a risk factor for adverse prognosis [1]. The poor prognosis is also reflected in the fact that older patients continue to experience increased mortality even five years after diagnosis [2].
Source: www.geriatriconcology.netCategories: General Medicine NewsTweet-
Representation of older adults in registrational trials associated with therapeutic approvals in diffuse large B-cell lymphoma https://t.co/vVJwZQYWgA @PallawiTorkaMD @neuendorff_nr @WilliamDale_MD @myCARG #GeriOnc #OlderAdults #OncoAlert #SIOG #YoungSIOG #Elsevier https://t.co/wxovdL5D32
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Mashup Score: 33
Over the years, the number of older adult patients with cancer has progressively increased. According to the GLOBOCAN 2022 database, half of all cancers are diagnosed in people ≥70 years. Lung cancer, with a median age at diagnosis of about 70 years, accounts for 12.4 % of all cancers worldwide and is also the leading cause of cancer death (18.7 %) [1]. The therapeutic proposal for older adult patients should not only be based on chronological age, but it should consider the functional age. Therefore, the International Society of Geriatric Oncology (SIOG) recommends performing a comprehensive geriatric assessment (CGA) to better evaluate the functional, psychological, cognitive, and nutritional status of patients [2].
Source: www.geriatriconcology.netCategories: General Medicine NewsTweet-
Association of G8 screening tool with prognosis and survival in patients with non-small cell lung cancer: A retrospective analysis from a single institution https://t.co/KfzhMLFiHM @WilliamDale_MD @myCARG #GeriOnc #OlderAdults #OncoAlert #SIOG #YoungSIOG #Elsevier #G8 #Screening https://t.co/rYQVod2ePZ
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Mashup Score: 6
Healthy aging is a process that allows for optimal functional ability and wellbeing, but little is known about older adults’ experiences living with and beyond cancer (also called survivorship). The purpose of this study was to explore the experiences and perceptions of healthy aging among older adults living with and beyond cancer.
Source: www.geriatriconcology.netCategories: General Medicine NewsTweet-
Living with and beyond cancer: What older adults tell us about healthy aging https://t.co/juwOisauoa @kristenhaase @WilliamDale_MD @myCARG #GeriOnc #OlderAdults #OncoAlert #SIOG #YoungSIOG #Elsevier #HealthyAging #CancerSurvivorship #QualityofLife #QualitativeResearch https://t.co/jFWKrzA9IJ
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Mashup Score: 6
Healthy aging is a process that allows for optimal functional ability and wellbeing, but little is known about older adults’ experiences living with and beyond cancer (also called survivorship). The purpose of this study was to explore the experiences and perceptions of healthy aging among older adults living with and beyond cancer.
Source: www.geriatriconcology.netCategories: General Medicine NewsTweet-
Living with and beyond cancer: What older adults tell us about healthy aging https://t.co/juwOisauoa @kristenhaase @WilliamDale_MD @myCARG #GeriOnc #OlderAdults #OncoAlert #SIOG #YoungSIOG #Elsevier #HealthyAging #CancerSurvivorship #QualityofLife #QualitativeResearch https://t.co/jFWKrzA9IJ
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Mashup Score: 10Patterns of presentation, treatment, and survival among older adults with metastatic breast cancer: Results from a large prospective registry - 11 day(s) ago
Older adults with breast cancer experience worse survival than their younger counterparts. However, data are limited on the patterns of presentation, treatment, and outcomes for older patients with metastatic breast cancer (MBC) outside of registry studies and selected clinical trial populations.
Source: www.geriatriconcology.netCategories: General Medicine NewsTweet-
Patterns of presentation, treatment, and survival among older adults with metastatic breast cancer: Results from a large prospective registry https://t.co/7hlOkQtDz7 @DrRFreedman @WilliamDale_MD @myCARG #GeriOnc #OlderAdults #OncoAlert #SIOG #YoungSIOG #Elsevier https://t.co/VUiOKe3IRj
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Mashup Score: 58Geriatric assessment in older adults with acute myeloid leukemia: A Young International Society of Geriatric Oncology narrative review - 13 day(s) ago
The therapeutic landscape of acute myeloid leukemia (AML) in older adults has been transformed by the advent of targeted therapies, including venetoclax (a B-cell lymphoma-2 inhibitor), gilteritinib (a FMS-like tyrosine kinase 3 inhibitor), ivosidenib, and enasidenib (isocitrate dehydrogenase 1/2 inhibitors). These agents, in combination with hypomethylating agents, have significantly improved outcomes among patients aged 60 years and older, however, overall survival remains very poor. Hence, the management of AML in this population requires a nuanced approach to balance overall survival, treatment-related toxicities, quality of life, and the preservation of functional independence.
Source: www.geriatriconcology.netCategories: General Medicine NewsTweet-
Geriatric assessment in older adults with acute myeloid leukemia: A Young International Society of Geriatric Oncology narrative review https://t.co/Yb7hp5AGDU @neuendorff_nr @WilliamDale_MD @myCARG #GeriOnc #OlderAdults #OncoAlert #SIOG #YoungSIOG #Elsevier https://t.co/hhauw46FP6
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Mashup Score: 11Concurrent chemotherapy for older patients with locoregionally advanced nasopharyngeal carcinoma: A randomized clinical trial - 16 day(s) ago
We aimed to evaluate the efficacy of two different radiotherapy strategies in elderly patients with locally advanced nasopharyngeal carcinoma (NPC) using geriatric assessment.
Source: www.geriatriconcology.netCategories: General Medicine NewsTweet-
Concurrent chemotherapy for older patients with locoregionally advanced nasopharyngeal carcinoma: A randomized clinical trial https://t.co/ANHbrIzZQt @WilliamDale_MD @myCARG #GeriOnc #OlderAdults #OncoAlert #SIOG #YoungSIOG #Elsevier #GeriatricAssessment #Chemotherapy https://t.co/2kRc9aCMoL
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Mashup Score: 13
Older adults diagnosed with cancer often have functional vulnerability and increased risk for treatment-related toxicity and poor outcomes, with emergent clinical strategies to mitigate these risks. The geriatric assessment (GA) is a widely recommended platform in the clinic to help inform treatment decisions and toxicity risk and initiate referrals, but incorporating the GA into busy clinical practice remains challenging.
Source: www.geriatriconcology.netCategories: General Medicine NewsTweet-
Preliminary experience supporting older adults with breast cancer: Successes, challenges, and next steps for a program embedded in a breast oncology center https://t.co/KMDMwTeTdh @DrRFreedman @WilliamDale_MD @myCARG #GeriOnc #OlderAdults #OncoAlert #SIOG #YoungSIOG #Elsevier https://t.co/T75HOPDw1K
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Mashup Score: 13Age and comorbidity in relation to treatment and survival outcomes in triple-negative breast cancer: A Swedish nationwide registry-based study - 20 day(s) ago
Patients with cancer and comorbidities often experience a longer time-to-diagnosis and significantly worse clinical outcomes. Here, we evaluate the association between age, Charlson Comorbidity Index (CCI), treatment given, and patient survival, thereby identifying common non-breast cancer-related causes of death in patients with triple-negative breast cancer (TNBC).
Source: www.geriatriconcology.netCategories: General Medicine NewsTweet-
Age and comorbidity in relation to treatment and survival outcomes in triple-negative breast cancer: A Swedish nationwide registry-based study https://t.co/8YWkN5JPCH @WilliamDale_MD @myCARG #GeriOnc #OlderAdults #OncoAlert #SIOG #YoungSIOG #Elsevier #CharlsonComorbidityIndex https://t.co/akDsDTfblC
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How to make recommendations on dosing for older adults receiving systemic cancer treatment – A holistic and pragmatic approach to decision-making with a focus on colorectal cancer https://t.co/xkLXDqxV0R @LipositsG @m_refaat8 @WilliamDale_MD @myCARG #GeriOnc #OlderAdults https://t.co/YOLfg6NTS3