Severe asthma presents a major challenge to health care and negatively affects the quality of life of patients. Understanding the factors predicting the development of severe asthma is limited.

Sublingual immunotherapy (SLIT) is a safe, effective therapy for the treatment of food allergy. Studies demonstrating SLIT efficacy have primarily used pharmaceutical glycerinated food extracts for the administration of food allergens, which may limit accessibility due to extract cost and availability.

Oral Immunotherapy (OIT) has exhibited great potential in the treatment of food allergy. However, there is no global consensus on best practices of OIT. Parents of allergic children often struggle with concerns regarding OIT methodology, safety, and lack of accessible educational resources. ChatGPT is a generative artificial intelligence chatbot from OpenAI recognized for its ability to formulate human-like conversations. Although applications of artificial intelligence in medical settings continue to be explored, the effectiveness of ChatGPT as an educational resource remains unknown for OIT.

Knowledge and understanding of mast cell biology and mast cell disorders has increased in the past several years, with new classifications of diseases for both clonal and non-clonal forms. Along with these classifications has come differing treatment paradigms, including novel therapies now approved for various forms of clonal mast cell disorders. Unfortunately, there is some lack of guidance on how best to utilize these therapies. This yardstick aims to provide the clinician with a review of available therapies to treat mast cell activation syndrome and indolent systemic mastocytosis and an evidence-based expert opinion approach regarding how best to utilize these therapies.

Chronic rhinosinusitis is a common inflammatory condition that often leads to significant sleep disturbances, negatively affecting quality of life. Although intranasal steroids are a standard treatment, their effect on sleep disturbances in chronic rhinosinusitis has not been extensively studied.

Patients with chronic rhinosinusitis with nasal polyps comorbid with asthma often experience poor outcomes after endoscopic sinus surgery.

Obesity is a risk factor for poor asthma control. Previous research suggests that patients with asthma and obesity have reduced responsiveness to corticosteroids. Recent studies indicate that body fat percentage may be more strongly associated with obesity-related diseases compared with body mass index. However, the relationship between body fat percentage and asthma, particularly regarding steroid sensitivity, remains unclear.