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Mashup Score: 1The effects of GIP, GLP-1 and GLP-2 on markers of bone turnover: a review of the gut–bone axis - 3 day(s) ago
Bone is a dynamic tissue continuously undergoing remodeling processes of resorption and formation to maintain bone mass and health. Food intake and the release of the gut-derived incretin hormones, including glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide 1 (GLP-1) and its ‘sister hormone’ glucagon-like peptide 2 (GLP-2), appear to regulate bone turnover processes in the postprandial state as part of the so-called gut–bone axis. The effects of these gut hormones on bone metabolism depend on their circulating concentrations. While at physiological concentrations, elicited by nutrient intake, GIP seems to be the main contributor to postprandial bone resorption; supraphysiological concentrations of gut hormones induce more potent and robust antiresorptive effects. This review provides an overview of the literature describing the role of gut-derived hormones in the regulation and maintenance of bone tissue. In addition, we describe the effects of gut hormone-ba
Source: joe.bioscientifica.comCategories: General Medicine News, EndocrinologyTweet
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Mashup Score: 2Sex Effects in Endocrine Health and Disease - 9 day(s) ago
Journal of Endocrinology special collection titled Sex Effects in Endocrine Health and Disease
Source: joe.bioscientifica.comCategories: General Medicine News, EndocrinologyTweet-
📢 NEW special collection: Sex Effects in Endocrine Health and Disease We welcome for submission studies which highlight both convergent and divergent responses in males and females, focusing on basic and translational science. Learn more: https://t.co/ULgLRoBoSF https://t.co/VKXSfRe6ts
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Mashup Score: 0LINC01094 as a diagnostic marker of osteoporotic fractures is involved in fracture healing - 17 day(s) ago
Fragility fractures are frequently observed among the elderly population with osteoporosis, and the fundamental process of fracture recovery relies on the differentiation of osteoblasts. LINC01094 was a crucial lncRNA in the regulation of the progression of diseases, but its role in osteoporotic fracture remained unclear. This study was to investigate alterations in the expression of LINC01094 in patients with osteoporotic fractures, evaluate its potential role as a diagnostic biomarker, and explore its effects on osteoblast differentiation. Circulating LINC01094 was tested using serum from 60 healthy individuals, 60 patients with osteoporosis, and 74 patients with osteoporotic fractures by RT-qPCR. The receiver operating characteristic curve was conducted to evaluate its diagnostic performance. The function of LINC01094 was measured in both MC3T3-E1 and BMSC cells. ALP activity detection and ELISA assay were performed to measure the osteogenesis markers, including OCN and Runx2 expres
Source: joe.bioscientifica.comCategories: General Medicine News, EndocrinologyTweet-
Jinhuang Xu et al. investigate alterations in the expression of LINC01094 in patients with osteoporotic fractures, evaluate its potential role as a diagnostic biomarker, and explore its effects on osteoblast differentiation. Read it here 👉 https://t.co/BqxykEnSrB https://t.co/irZqfiCyQn
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Mashup Score: 0Endocrine Excellence: Discovery Science at SfE BES 2025 - 2 month(s) ago
Endocrine Excellence: Discovery Science at SfE BES 2025 Special Collection
Source: joe.bioscientifica.comCategories: General Medicine News, EndocrinologyTweet-
Submit your paper to the Endocrine Excellence: Discovery Science at #SfEBES2025 Special Collection, and put your research in the spotlight! 👋 Visit the Bioscientifica stand for more information or 📨 joe@bioscientifica.com. Learn more 👉 https://t.co/XzkWFVKE6s https://t.co/gkU9LeXSJV
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Mashup Score: 1Thirty years of StAR gazing. Expanding the universe of the steroidogenic acute regulatory protein - 3 month(s) ago
The current understanding of the biology, biochemistry and genetics of the steroidogenic acute regulatory protein (StAR) and its deficiency state (lipoid congenital adrenal hyperplasia, lipoid CAH) involves the complex interplay of four areas of study: the acute regulation of steroidogenesis, clinical phenomena in lipoid CAH, the enzymatic conversion of cholesterol to pregnenolone in steroidogenic mitochondria, and the cell biology of StAR. This review traces the origins of these areas of study, describes how they have been woven into an increasingly coherent fabric and tries to explore some remaining loose ends in this ongoing field of endocrine research. Extensive research from multiple laboratories has established that StAR is required for the rapid, abundant steroidal responses of the adrenals and gonads, but all steroidogenic cells, especially the placenta, also have StAR-independent steroidogenesis, whose basis remains under investigation. Lipoid CAH is the StAR knockout of natur
Source: joe.bioscientifica.comCategories: General Medicine News, EndocrinologyTweet-
Read the latest article in Journal of Endocrinology's #StAR Anniversary Collection: 'Thirty years of StAR gazing. Expanding the universe of the steroidogenic acute regulatory protein' by Walter L Miller @UCSF 👉 https://t.co/JmCY1HY0gx https://t.co/IekbG6IHnH
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Mashup Score: 2
Glucagon-like peptide-1 receptor (GLP-1R) and neuropeptide Y receptors (NPYRs) are expressed in reproductive tissues contributing to the regulation of gonadal function. This exploratory study examines the potential impact of their modulation by assessing the effects of exendin-4 (Ex-4) and peptide YY (PYY) (3–36) on endocrine ovaries and adrenals in high-fat diet (HFD) mice. Ex-4 and PYY(3–36) reduced blood glucose and energy intake, with no effects on body weight. While HFD did not impact the estrous cycle, Ex-4 increased metestrus frequency and decreased diestrus frequency resulting in 0% mice experiencing repeated diestrus or becoming acyclic. Luteinizing hormone levels were significantly higher in the Ex-4 and PYY(3–36) groups compared to the normal diet and HFD controls. In the adrenals, reduced capsule and zona glomerulosa thickness caused by HFD was reversed after peptide treatments. Within the ovaries, HFD increased the number of atretic follicles, an effect that disappeared af
Source: joe.bioscientifica.comCategories: General Medicine News, EndocrinologyTweet-
Dawood Khan et al. @ulsteruni investigated the potential therapeutic role of extrinsic modulators of #NPY2R and #GLP-1R in estrous cycling, changes in circulating reproductive hormones and their concurrent effects on #ovarian and #adrenal morphology. 👉 https://t.co/8va258zlQt https://t.co/EHIOaHFLw5
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Mashup Score: 1The role of glucagon-like peptides in osteosarcopenia - 3 month(s) ago
Various metabolic abnormalities, including obesity, insulin resistance, hypertension, dyslipidemia, hyperthyroidism and low vitamin D levels, have been linked to both osteopenia and sarcopenia. Osteosarcopenia is also commonly observed in older age groups, notably in postmenopausal women. Glucagon-like peptide-1 (GLP-1), a labile incretin secreted from the intestinal L-cells, stimulates insulin secretion and sensitivity, making it an effective anti-diabetic medication. GLP-1 binds to its receptor, the GLP-1 receptor, a G-protein-coupled receptor, and leads to the stimulation of adenylate cyclase, increasing the levels of cyclic AMP (cAMP). Elevated cAMP then activates protein kinase A and other downstream signaling pathways. These signaling cascades result in various cellular responses, such as enhanced insulin secretion from pancreatic beta cells, improved insulin sensitivity and modulation of appetite and gastric emptying. In addition, GLP-1 signaling can promote cell growth and surv
Source: joe.bioscientifica.comCategories: General Medicine News, EndocrinologyTweet-
Read the latest article in Journal of Endocrinology's Exploring #Osteoporosis and #Sarcopenia Special Collection: 'The role of glucagon-like peptides in osteosarcopenia' by Enaya Tufail et al. 👉 https://t.co/KA5J0Sf2oD #GLP1 https://t.co/JZf9Zlz4yF
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Mashup Score: 2Sex Effects in Endocrine Health and Disease - 4 month(s) ago
Journal of Endocrinology special collection titled Sex Effects in Endocrine Health and Disease
Source: joe.bioscientifica.comCategories: General Medicine News, EndocrinologyTweet-
📢 NEW special collection: Sex Effects in Endocrine Health and Disease We welcome for submission studies which highlight both convergent and divergent responses in males and females, focusing on basic and translational science. Learn more: https://t.co/ULgLRoBoSF https://t.co/VKXSfRe6ts
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Mashup Score: 4
Thyroid cancer is the most prevalent endocrine cancer, and the prognosis depends on the type and stage of cancer at the time of discovery. The treatment involves (hemi-)thyroidectomy, possibly followed by additional therapeutic options. After treatment, patients are monitored using serum concentrations of endocrine tumour markers: thyroglobulin (Tg) in case of differentiated cancer and calcitonin in case of medullary thyroid cancer. Measuring Tg and calcitonin concentrations in serum may be challenging. In this review, we provide a complete overview of the evolution in laboratory measurements of Tg and calcitonin, with an emphasis on (pre-)analytical challenges and potential approaches to overcome current pitfalls.
Source: joe.bioscientifica.comCategories: General Medicine News, EndocrinologyTweet-
Amber Mater et al. @amsterdamumc provide an overview of the evolution in laboratory measurements of #thyroglobulin and #calcitonin, with an emphasis on (pre-)analytical challenges and potential approaches to overcome current pitfalls 👉 https://t.co/JttmRqoRHd https://t.co/DxFN9nxJ3T
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Mashup Score: 0Oncostatin M: friend or foe in PCOS pathogenesis? - 4 month(s) ago
Polycystic ovary syndrome (PCOS) is a primary endocrinological disorder in women of reproductive age that is characterized by androgen excess and ovulatory irregularities. This syndrome is associated with adipose tissue dysfunction, an elevated risk of insulin resistance, hyperinsulinemia, obesity, and type 2 diabetes. Adipocyte dysfunction affects the secretion of adipokines and pro-inflammatory cytokines. Nevertheless, adipose tissue is not an exclusive source of adipokines as it can also be produced locally by reproductive tissues. Although adipokines have been recognized in the development of PCOS, the role of oncostatin M (OSM), a multifaceted adipokine, remains unclear. Current evidence suggests that this cytokine is associated with key aspects of the syndrome, including obesity, insulin resistance, hyperandrogenism, and inflammation. However, the data are often contradictory, likely due to variations in study designs, methodologies, and species differences. By investigating the
Source: joe.bioscientifica.comCategories: General Medicine News, EndocrinologyTweet-
By investigating the link between #oncostatin M and polycystic ovary syndrome-associated issues, this review by By Saba Nikanfar @UCLouvain_be et al. identified the potential role of this adipokine in #PCOS pathogenesis. Read it here 👉 https://t.co/NWIFu25MKE https://t.co/zpcdxIdosn
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Read the latest article in Journal of Endocrinology's #Incretins Special Collection: 📍 The effects of GIP, GLP-1 and GLP-2 on markers of bone turnover: a review of the gut–bone axis By Miriam Longo et al. 👉 https://t.co/9Wt5Cqwq0F https://t.co/RFIDFPx1Br