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Mashup Score: 15Spatial Distribution of Calcium Sparks Determines Their Ability to Induce Afterdepolarizations in Human Atrial Myocytes: - 3 year(s) ago
Highlights • A newly developed analysis methodology uncovers a preferential increase in calcium sparks near the sarcolemma in myocytes from patients with AF, which is linked to higher ryanodine rec…
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Mashup Score: 0
IntroductionLike many people, I was completely taken in and simultaneously taken aback by the public release of ChatGPT (GPT stands for “generative pretrained transformer”), the natural language processing tool that allows one to have a personalized conversation with an artificial intelligence (AI) bot capable of providing detailed responses to questions (prompts) with uncanny speed. ChatGPT is…
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Check out this “interview” between @DLMann_MD and #ChatGPT about the future of AI in translational medicine. A thought-provoking discussion! https://t.co/9lqUJCO3DX #JACCBTS #CardioTwitter #ACCHI #AI #MedTwitterAI #TranslationalMedicine @OpenAI https://t.co/3Vz6fX4oax
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Mashup Score: 2Genetic Ablation of the DNA Damage Response Pathway Attenuates Lamin-Associated Dilated Cardiomyopathy in Mice: - 3 year(s) ago
Highlights • The LMNA protein is involved in genomic stability. • Mutations in the LMNA gene caused DCM. • DSBs are increased in DCM. • DSBs, released into the cytoplasm, are sensed by CGAS, which …
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#JACCBTS study indicates that targeting the CGAS/DDR pathway might be beneficial in the treatment of dilated cardiomyopathy caused by mutations in the LMNA gene. https://t.co/h1BLg4vkvE #cvDCM #HeartFailure #DNA #BasicScience #TranslationalScience #CardioTwitter https://t.co/1ANvk1PJml
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Mashup Score: 0Targeting the Autophagy-Lysosome Pathway in a Pathophysiologically Relevant Murine Model of Reversible Heart Failure: - 3 year(s) ago
Highlights • The biological drivers of reverse LV remodeling are not well understood. • Transaortic constriction induced hemodynamic pressure overload superimposed on acute LAD ligation in mice res…
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What is the therapeutic relevance of enhancing autophagic flux in the heart? Find out in #JACCBTS: https://t.co/hzWzf1HmWC #HeartFailure #openaccess #BasicResearch #TranslationalScience #CardioTwitter @DLMann_MD https://t.co/zVreb67j10
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Mashup Score: 1A Novel Puncturable Atrial Septal Defect Occluder: The Results of Preclinical Experiment and First-in-Human Study - 3 year(s) ago
Highlights • In the presence of an ASD occluder, the subsequent puncture of the atrial septum for such patients may be challenging, and this important route for left-sided interventional procedures…
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First-in-human study of a puncturable atrial septal defect occluder. https://t.co/pJWPv2N26t #JACCBTS #openaccess #BasicResearch #TranslationalScience #CardioTwitter https://t.co/27sKCLQA9g
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Mashup Score: 0Safety and Tolerability of Nicotinamide Riboside in Heart Failure With Reduced Ejection Fraction: - 3 year(s) ago
Highlights • Boosting NAD+ by NR has been shown to blunt worsening of cardiac function in murine cardiomyopathy models and suggested to have anti-inflammatory effects a small, nonrandomized clinica…
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Can nicotinamide riboside be a potential therapy for #HeartFailure patients? Learn more in #JACCBTS: https://t.co/joqtq21IRk #openaccess #BasicResearch #HFrEF #CardioTwitter https://t.co/s5w74PpMdt
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Mashup Score: 1
Highlights • FRDA is a progressive metabolic disease with mitochondrial dysfunction. • Patients can develop a cardiomyopathy associated with heart failure and death. • A single gene defect decrease…
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Read this #JACCBTS state-of-the-art review describing the current basic and clinical understanding of the FRDA heart, and most importantly, identifying major gaps in our knowledge that represent new directions and opportunities for research. https://t.co/a3Ijy4ltfx #CardioTwitter https://t.co/Xn7lKLgDjq
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Mashup Score: 1
Corresponding Author
Categories: Cardiologists, Latest HeadlinesTweet-
Now @JACCJournals a novel pre-clinical & FIH study of a ‘Puncturable’ ASD occluder. In the accompanying editorial, I discuss the history of innovations to facilitate LA re-access & the remaining challenges https://t.co/0vzkAcBLWf https://t.co/gRDbnRFvLU
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Mashup Score: 1
Highlights • FRDA is a progressive metabolic disease with mitochondrial dysfunction. • Patients can develop a cardiomyopathy associated with heart failure and death. • A single gene defect decrease…
Categories: Cardiologists, Latest HeadlinesTweet-
RT @Ed_Alania: https://t.co/jgCSjYOnPZ
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Mashup Score: 2Novel GSK-3β Inhibitor Neopetroside A Protects Against Murine Myocardial Ischemia/Reperfusion Injury: - 3 year(s) ago
Highlights • Neopetroside A preserved cardiac hemodynamics and mitochondrial respiration capacity ex vivo after ischemia/reperfusion injury in rat hearts. • NPS A significantly prevented cardiac fi…
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How does neopetroside A prevent cardiac fibrosis in mouse model of myocardial infarction? Find out in #JACCBTS: https://t.co/DDDhf68aLt #openaccess #BasicResearch #TranslationalScience #cvMI #CardioTwitter https://t.co/b2mxD21kow
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Analysis of atrial myocytes from patients with #AFib reveals a preferential increase in calcium sparks near the sarcolemma. This spatiotemporal distribution is key to increased afterdepolarizations in these cells. https://t.co/lrmPLTAbrQ #JACCBTS #ACCEP #EPeeps #CardioTwitter https://t.co/IDaF527Y45