Medications and Risk for Microscopic Colitis: A Nationwide Study of Older Adults in Sweden | Annals of Internal Medicine
Background: Several medications have been identified as potential risk factors for microscopic colitis (MC), but evidence so far is hampered by methodological limitations. Objective: To examine the potential causal effects of previously implicated medications on risk for MC. Design: Emulation of 6 target trials. Setting: Sweden. Participants: All residents in Sweden aged 65 years or older between 2006 and 2017 who met eligibility criteria (n = 191 482 to 2 634 777). Measurements: The primary outcome was biopsy-verified MC. The date of diagnosis was obtained from the nationwide histopathology cohort ESPRESSO (Epidemiology Strengthened by histoPathology Reports in Sweden). Twelve- and 24-month cumulative incidences and absolute risk differences for MC were estimated via inverse probability weighing. Results: The 12- and 24-month cumulative incidences of MC were less than 0.5% under all treatment strategies. Estimated 12-month risk differences were close to null under angiotensin-converti
