Long-term Outcomes of Primary Fistula Closure with… : Diseases of the Colon & Rectum
s a tissue regenerator. OBJECTIVE: To assess the 5-year cure rate and complications among patients with complex perianal fistula treated with plasma therapy. DESIGN: A prospective, observational study conducted from 2011 to 2022. Patients with complex perianal fistula who met the inclusion criteria were treated with plasma rich in growth factors. Follow-up and assessment were performed for 5 years after treatment, with visits at 1, 3, 6, 12, 36, and 60 months. SETTING: This study was conducted at a single tertiary referral centre. PATIENTS: Data from 166 patients were assessed. MAIN OUTCOME MEASURES: The primary outcome measure was the rate of fistula healing and the secondary outcome measures assessed recurrence, continence status, and complications. RESULTS: A total of 166 patients with cryptoglandular complex perianal fistula (68.7% male, mean age 51.4 ± 13.2 years) were included. The majority of the fistulas (88.5%) were trans-sphincteric; 87.8% were relapsed fistulas, with a mean
