Comparative effectiveness of interventions to facilitate deprescription of benzodiazepines and other sedative hypnotics: systematic review and meta-analysis
Objective To review evidence from randomised trials assessing the effectiveness of strategies to deprescribe benzodiazepines and closely related sedative hypnotics (BSH). Design Systematic review and meta-analysis of randomised controlled trials. Data sources MEDLINE, Embase, CINAHL, PsycInfo, and CENTRAL, searched from inception to August 2024, and reference lists of included studies and similar systematic reviews. Eligibility criteria for selecting studies Eligible studies randomised adults using BSH for insomnia to interventions aimed at deprescribing BSH, strategies to implement these interventions in healthcare settings, or usual care or placebo. Methods Reviewers worked independently and in duplicate to screen search results, extract data, and assess risk of bias. Similar interventions were grouped together, frequentist random effects meta-analysis was conducted, and the certainty of evidence was assessed using the GRADE (Grading of Recommendations Assessment, Development, and Ev
