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Coeliac disease and the intestinal barrier: mechanisms of disruption and strategies for restoration
Coeliac disease is characterised by immune-mediated damage to the small intestine in response to dietary gluten in genetically predisposed individuals. Increased intestinal permeability is a…
Helicobacter pylori antibiotic resistance: a global challenge in search of solutions
Background Helicobacter pylori resistance to antibiotics commonly used in eradication regimens is increasing dramatically in many locations; new strategies are needed to manage this infectious…
Opposite regulation of intestinal and intrahepatic CD8+ T cells controls alcohol-associated liver disease progression
Background Gut-liver crosstalk plays an important role in alcohol-associated liver disease (ALD) pathogenesis; but underlying mechanisms remain obscure. Objective We examined the regulation of intestinal…
Stressed hepatocyte sustains alcohol-associated hepatitis progression by producing leukocyte cell-derived chemotaxin 2
Background Neutrophil infiltration and hepatocyte damage are indispensable hallmarks in alcohol-associated hepatitis (AH), yet the underlying crosstalk between neutrophils and hepatocytes and its role in…
Multimodal transcriptomics identifies metallothionein as a… : Hepatology
and single-nuclei transcriptomics (snRNA-seq) to analyze biopsies from a spectrum of PSC and disease control explants. Approach and Results: Liver specimens from 23 PSC (transplant…
Dietary whey protein protects against Crohn’s disease by orchestrating cross-kingdom interaction between the gut phageome and bacteriome
Background The gut microbiome and diet are important factors in the pathogenesis and management of Crohn’s disease (CD). However, the role of the gut phageome…
Single-cell omics in inflammatory bowel disease: recent insights and future clinical applications
Inflammatory bowel diseases (IBDs), which include ulcerative colitis (UC) and Crohn’s disease (CD), are chronic conditions characterised by inflammation of the intestinal tract. Alterations in…
British Society of Gastroenterology guidelines on inflammatory bowel disease in adults: 2025
In response to recent advancements in inflammatory bowel disease (IBD) management, the British Society of Gastroenterology (BSG) Clinical Services and Standards Committee (CSSC) has commissioned…
Tertiary lymphoid structures in hepatocellular carcinoma:… : Hepatology
tectomy is unclear. Approach and Results: We analyzed the prevalence and maturity of TLS in tumors, the associations of such structures with survival after hepatectomy…
Tertiary lymphoid structures in hepatocellular carcinoma:… : Hepatology
tectomy is unclear. Approach and Results: We analyzed the prevalence and maturity of TLS in tumors, the associations of such structures with survival after hepatectomy…