In this review, Roth et al. provide a comprehensive overview of the history and current state of the precision epigenetic editing field. They thoroughly outline existing targeted epigenetic editing tools and their constraints and describe how concurrent improvements in delivery technologies will facilitate ongoing therapeutic applications of epigenetic editing.
A large, unbiased biochemical screen discovers inhibitors of SMURF1 that reverse established pulmonary arterial hypertension by extending an α helix over a conserved glycine hinge…
Sonogenetic EchoBack-CAR T cells were designed with an ultrasensitive heat-shock promoter screened from a library and a synthetic positive feedback loop that reprograms tumor engagement into…
Sajiki and colleagues used nanopore long-read sequencing to evaluate genomic integrity and packaged DNA patterns in AAV vectors with various genome sizes. This analysis provided…
Xu and colleagues developed a novel oncolytic adenovirus, rAd.sT.GM, which reverses TGF-β-mediated immunosuppression and enhances GM-CSF-mediated immunoactivation. It demonstrated safety and effectiveness in a TNBC…
Li et al. reported an interim analysis of a single-center, single-arm pilot trial evaluating a β-globin expression-optimized and insulator-engineered lentivirus-modified cell product in the most severe…
Dunbar and colleagues identified Poloxamer 407 (P407) as a novel enhancer for lentiviral transduction of rhesus macaque and human NK cells. Using this method, they…
KPC-I cells derived from the murine pancreatic cancer model LSL-KrasG12D; LSL-Trp53R172H; Pdx-Cre are permissive to adenoviral replication. High susceptibility to adenovirus-induced autophagic cell death results…
Dysfunctional meningeal lymphatics interfere with the inhibitory synaptic inputs and disrupt excitatory/inhibitory balance on cortical neurons in a microglia-IL-6-dependent manner. Enhancing the function of meningeal…
In this issue of Cancer Cell, Teng et al. discover that small cell lung cancer and neuroendocrine prostate cancer highly express a circular RNA known as…
