Song et al. show that YAP/TAZ signaling in PDGFRα-expressing fibroblasts plays a crucial role in supporting alveolar epithelial stem cells. Their study shows that fibroblast-specific knockdown of YAP/TAZ enhances the ability of PDGFRα+ fibroblasts to support AT2 cell proliferation via Wnt4, highlighting potential pathways for improving lung repair and regeneration.
The upsurge of mpox (formerly known as monkeypox) in Africa and its global spread highlight the need for improved vaccines. The development of new recombinant…
A single taste receptor initiates our reactions to both sugars and artificial sweeteners, triggering a signaling process that drives our intense attraction to sweet foods.…
Antibiotic resistance is an increasing global concern. Duong et al. uncover a synergistic mechanism between histones and antimicrobial peptides that could pave the way to…
Chen et al. reveal that OTUD4 plays a dual role in ferroptosis resistance by stabilizing GPX4 and modulating autophagy. Its inhibition potentiates ferroptosis and enhances regorafenib…
Recombination-aware evolutionary analyses of the entire genomes of SARS-CoV-1-like and SARS-CoV-2-like viruses indicate that SARS-CoV-1 and SARS-CoV-2 descend from bat coronaviruses that circulated as recently…
Initial specificity is thought to be required for somatic hypermutation (SHM)-driven antibody evolution. Zuo, Gautam, et al. demonstrate that non-cognate B cells can enter germinal centers,…
In this study, Jung et al. investigate the effect of excessive NLRP3-mediated neuroinflammation on synaptic functions and behaviors using Nlrp3D301N-conditional knockin mice. Strikingly, excessive NLRP3-mediated neuroinflammation…
Microglia play a crucial role in regulating proper brain formation, with their activity being both spatially and temporally controlled. Matteoli and colleagues summarize the known…
HIV-1 is highly prone to mutations, and a vaccine must stimulate production of antibodies targeting conserved determinants on its exposed envelope glycoprotein (Env). Such broadly…
Rotariu et al. show that somatostatin (SOM) interneurons mediate cell-specific control of the initial motor learning performance and the associated reorganization of dorsomedial striatum (DMS).…
