Win Ratio Analysis of the REVERSE Cardiac Resynchronization Trial
The novel win ratio (WR) statistic has emerged as a promising alternative endpoint for the comparison of two treatment groups on multiple endpoints simultaneously, but it has not been used for cardiac resynchronization therapy (CRT) trials. REVERSE was the first multicenter, randomized CRT trial in mild heart failure (HF). The primary result was a non-significant reduction in the proportion of CRT patients with worsened Clinical Composite Score (CCS) compared to control. However, CRT did improve reverse remodeling measures and delayed time to first HF hospitalizations.
