Vaccination campaigns have reshaped infectious disease dynamics, exerting selective pressures on pathogens. While some are controlled, others persist via antigenic variation or reservoirs. This Science & Society explores the evolutionary and ecological impacts of vaccination, highlighting its role in pathogen adaptation and implications for future disease control strategies.
In this review, Prinz and Frosch describe how the central nervous system is partitioned into distinct immune niches, each hosting unique myeloid cell populations that…
Robot-assisted analysis and theoretical modeling of TCR/CAR crosstalk enable the design of adoptive T cell therapies that maximize anti-tumor activity and minimize toxicity in healthy tissues.
Studies of peripheral neuroimmunology have unveiled sensory biology as a powerful new lens through which both immunology and neuroscience can be viewed. In this perspective,…
Structural elucidation of the human muscle acetylcholine receptor bound to pathogenic autoantibodies from myasthenia gravis patients defines epitopes and mechanisms underlying channel inhibition and disease.
In this review, Prinz and Frosch describe how the central nervous system is partitioned into distinct immune niches, each hosting unique myeloid cell populations that…
Alzheimer’s disease (AD) and age-related macular degeneration (AMD) share immune-related mechanisms such as microglial activation, amyloid beta deposits, and complement dysregulation, yet also involve distinct tissue-specific…
Recent discoveries of glymphatics and meningeal lymphatics have redefined our understanding of CNS immunosurveillance. Kim and Kipnis illustrate how the clearance of brain-derived antigens creates…
Recent discoveries of glymphatics and meningeal lymphatics have redefined our understanding of CNS immunosurveillance. Kim and Kipnis illustrate how the clearance of brain-derived antigens creates…
Tree-of-life scale genotype-habitat association reveals conserved gene modules across thousands of gut microbial species and identifies previously undescribed factors that modulate microbial colonization in the…
Pseudomonas syringae can detect and kill microbial predators via a chemical radar (Cra), which also allows the bacterium to infect plants despite predation pressure.
