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    Molecular chirality is critical to biochemical function, but it is unknown when chiral selectivity first became important in the evolutionary transition from geochemistry to biochemistry during…

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    The recent approval of suzetrigine for acute pain treatment highlights both the success of targeting peripheral sensory neurons for pain management and the potential of developing new pain therapies primarily in human-based systems. To realize this transformative potential, further research into somatosensation and pain neuroimmunology in human systems is essential.

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    Organoids are tiny stem cell-derived 3D in vitro cell culture systems mimicking the structural and functional aspects of the tissues in the human body and provide a means to study complex bio-physiological processes in normal and disease states (disease modeling) and also for therapeutic screening and clinical trials. Scientists have now developed protocols to maintain and use organoids from diverse human tissues, including the gut, liver, brain, and pancreas, and they have the potential to reduce or remove the dependency on animal models and have research utility and translational potential.

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    This Medical News article highlights recent research into olfactory deficits in older adults and mortality risk, including factors that mediate this relationship.

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    • Sense of Smell Is a #Marker for Mortality Risk, With Dementia and Frailty as Key Mediators 1. https://t.co/N3GrummbcM 2. https://t.co/b0rKcDfB4v 3. https://t.co/CElGSudGUY “Your sense of smell is not only your smell and taste,” he said. “It’s your memory and your perception https://t.co/jnnAOIUN7o

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    We tackle the hard problem of consciousness taking the naturally selected, embodied organism as our starting point. We provide a formalism describing how biological systems self-organise to…

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