• Mashup Score: 14
    Continuing SARS-CoV-2 evolution under population immune pressure - 3 year(s) ago

    Trevor Bedford (@trvrb) Fred Hutchinson Cancer Center / Howard Hughes Medical Institute 6 Apr 2022 Vaccines and Related Biological Products Advisory Committee Meeting FDA   Slides at: bedford.io/talks Continuing SARS-CoV-2 evolution under population immune pressure Trevor Bedford (@trvrb) Fred…

    Source: bedford.io
    Categories: Infectious Disease, Latest Headlines
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      trvrb

      Today, I presented to @US_FDA VRBPAC with an overview of SARS-CoV-2 evolution up to this point and a brief perspective for what to expect going forward. Slides are here: https://t.co/QnzOctVCSN and my slot in the full recording is viewable here: https://t.co/n5rlgOvtEg. 1/13

  • Mashup Score: 0
    Tracking an FDA advisory panel meeting on Covid-19 vaccines and boosters - 3 year(s) ago

    On the agenda of the FDA’s advisory panel on vaccines today: boosters and the possibility of updating the vaccines to better match circulating SARS-CoV-2 strains.

    Source: STAT
    Categories: Infectious Disease, Latest Headlines
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      trvrb

      Some of the discussion today focused on how to assess that the vaccine isn’t working well enough such that an update is warranted (text from @DrewQJoseph's reporting here: https://t.co/1azNIBNfuL). 6/13 https://t.co/v0lsASjBvt

  • Mashup Score: 0
    Boosting with variant-matched or historical mRNA vaccines protects against Omicron infection in mice - 3 year(s) ago

    A comparison of the immunogenicity and efficacy of Omicron BA.1-matched and historical mRNA vaccines as boosters shows that while boosting with either vaccine increased neutralizing titers against Omicron BA.1 and BA.2, slightly greater protection against BA.1 challenge was observed in mice boosted with the BA.1-matched vaccine.

    Source: Cell
    Categories: Infectious Disease, Latest Headlines
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      trvrb

      We have results from animal models showing higher titers in mice that receive boost with Omicron-specific vaccine (figure from Ying et al https://t.co/Rg7GNn8aYn) and we can expect clinical trial results from people soon. 8/13 https://t.co/lVAlDIM5X1

  • Mashup Score: 153
    Nextstrain / ncov / gisaid / global - 4 year(s) ago

    Genomic epidemiology of novel coronavirus – Global subsampling

    Source: nextstrain.org
    Categories: Infectious Disease, Latest Headlines
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      trvrb

      For comparison Alpha, Beta and Gamma are each about as divergent from each other in terms of amino acid changes across the genome as Omicron 21K and 21L are from each other. Figure from @nextstrain (https://t.co/oQIbidkrxJ). 3/15 https://t.co/8Ge1ST3qK5

  • Mashup Score: 86
    outbreak.info - 4 year(s) ago

    outbreak.info is a standardized, searchable platform to discover and explore COVID-19 and SARS-CoV-2 data from the Center for Viral Systems Biology (cvisb.org) at Scripps Research. It contains three parts: a standardized searchable database of COVID-19 research; customizable real-time surveillance reports on SARS-CoV-2 variants and mutations; and an explorable interface to examine changes in…

    Source: outbreak.info
    Categories: Infectious Disease, Latest Headlines
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      trvrb

      The heavily mutated receptor binding domain (RBD) of the spike protein that distinguishes Omicron from Delta is largely shared between 21K and 21L, while differences exist in the near terminal domain (NTD). Figure from https://t.co/dIaCP7CGt0. 4/15 https://t.co/fS6iSjMRTF

  • Mashup Score: 4
    Evidence for adaptive evolution in the receptor-binding domain of seasonal coronaviruses OC43 and 229E - 4 year(s) ago

    Seasonal coronaviruses (OC43, 229E, NL63 and HKU1) are endemic to the human population, regularly infecting and reinfecting humans while typically causing asymptomatic to mild respiratory infections. It is not known to what extent reinfection by these viruses is due to waning immune memory or antigenic drift of the viruses. Here, we address the influence of antigenic drift on immune…

    Source: bedford.io
    Categories: Healthcare Professionals, Latest Headlines
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      trvrb

      @BillHanage @iddux @ENirenberg @baym @maryebushman Seasonal coronavirus OC43 and 229E have similar rates of adaptive evolution as flu B viruses (https://t.co/CGeN6dQJsP). SARS-CoV-2 has much more going on in terms of evolution at S1. Figures from https://t.co/1BlsrKINhq. https://t.co/QBSmAIRO3Z

  • Mashup Score: 74
    SARS-CoV-2 variant dynamics across US states show consistent differences in effective reproduction numbers - 4 year(s) ago

    Accurately estimating relative transmission rates of SARS-CoV-2 Variant of Concern and Variant of Interest viruses remains a scientific and public health priority. Recent studies have used the sample proportions of different variants from sequence data to describe variant frequency dynamics and relative transmission rates, but frequencies alone cannot capture the rich epidemiological…

    Source: bedford.io
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      trvrb

      If we partition @CDCgov cases between Delta and Omicron using @GISAID sequence data following approach by @marlinfiggins (https://t.co/Uq7Nl2mI2R) we can see clear Omicron epidemics. 3/9 https://t.co/Y41HPdJIhB

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