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Mashup Score: 1Tisagenlecleucel in pediatric and young adult patients with Down syndrome-associated relapsed/refractory acute lymphoblastic leukemia - Leukemia - 3 year(s) ago
Children with Down syndrome have a 20 times higher risk of developing a type of blood cancer called Down syndrome-associated acute lymphoblastic leukemia (ALL). Children who develop Down syndrome-associated ALL typically receive chemotherapy to treat their cancer; however, they can experience severe toxicity or other consequences from these therapies, especially stem cell transplant, and have a…
Source: NatureCategories: Hem/Oncs, Latest HeadlinesTweet
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Mashup Score: 0
Background: Reduced intensity conditioning (RIC) regimens frequently provide insufficient disease control in patients with high-risk hematological malignancies undergoing allogeneic hematopoietic stem cell transplantation (HSCT).Objective and Study Design: We evaluated intensification of fludarabine/busulfan (Flu/Bu) RIC with targeted marrow irradiation (TMI) in a dose escalation with expansion…
Categories: Hem/Oncs, Latest HeadlinesTweet
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Mashup Score: 0Covid-19 Boosters — Where from Here? | NEJM - 3 year(s) ago
Editorial from The New England Journal of Medicine — Covid-19 Boosters — Where from Here?
Source: New England Journal of MedicineCategories: Hematologists1, Latest HeadlinesTweet
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Mashup Score: 1Are We About to Cure Sickle-Cell Disease? - 3 year(s) ago
New gene therapies hold extraordinary promise, but they might not be enough to overcome a medical system that marginalizes Black Americans.
Source: The New YorkerCategories: Hematologists1, Latest HeadlinesTweet
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Mashup Score: 0How to Treat Breast Cancer After Childhood Cancer: Management of Oncologic and Cardiovascular Concerns - 3 year(s) ago
Highlights • Childhood cancer survivors are at higher risk for the development of breast cancer necessitating early breast cancer screening, often with both breast MRI and mammography. • Risk-strat…
Source: JACC: CardioOncologyCategories: Hem/Oncs, Latest HeadlinesTweet
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Mashup Score: 1Estimating excess mortality due to the COVID-19 pandemic: a systematic analysis of COVID-19-related mortality, 2020–21 - 3 year(s) ago
The full impact of the pandemic has been much greater than what is indicated by reported deaths due to COVID-19 alone. Strengthening death registration systems around the world, long understood to be crucial to global public health strategy, is necessary for improved monitoring of this pandemic and future pandemics. In addition, further research is warranted to help distinguish the proportion of…
Source: The LancetCategories: Hem/Oncs, Latest HeadlinesTweet
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Mashup Score: 0Wolters Kluwer Health - 3 year(s) ago
JavaScript Error JavaScript has been disabled on your browser. You must enable it to continue. Here’s how to enable JavaScript in the following browsers: Internet Explorer From the Tools menu, select Options Click the Content tab Select Enable…
Source: lww.comCategories: Hem/Oncs, Latest HeadlinesTweet
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Mashup Score: 0
Chronic graft versus host disease (cGvHD) is a late onset, non-infectious complication of haematopoietic stem cell transplantation (HSCT)1, 2. Pulmonary cGvHD (p-cGvHD) is a highly morbid manifestation of this condition3 and occurs in almost 25% of children diagnosed with cGvHD4, 5. Clinically, p-cGvHD presents with respiratory signs and symptoms of small airways disease (wheeze, cough, shortness…
Categories: Hem/Oncs, Latest HeadlinesTweet
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Mashup Score: 0Bone marrow surveillance of pediatric cancer survivors identifies clones that predict therapy-related leukemia - 3 year(s) ago
Abstract. Purpose: Therapy-related myelodysplastic syndrome and acute leukemias (t-MDS/AL) are a major cause of non-relapse mortality amongst pediatric cancer survivors. While the presence of clonal hematopoiesis (CH) in adult patients at cancer diagnosis has been implicated in t-MDS/AL, there is limited published literature describing t-MDS/AL development in children. Experimental design: We…
Categories: Hem/Oncs, Latest HeadlinesTweet
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Mashup Score: 1
Correspondence from The New England Journal of Medicine — Efficacy of Antibodies and Antiviral Drugs against Covid-19 Omicron Variant
Source: New England Journal of MedicineCategories: Hematologists1, Latest HeadlinesTweet
Tisagenlecleucel in pediatric and young adult patients with Down syndrome-associated relapsed/refractory acute lymphoblastic leukemia | Leukemia https://t.co/85NqH7zmEM