• Mashup Score: 5

    Purpose: Epigenetic modulators improve immune checkpoint inhibitor (ICI) efficacy and increase CD8+ effector: FoxP3+ regulatory T cell ratios in preclinical models. We conducted a multicenter phase I clinical trial combining the histone deacetylase (HDAC) inhibitor entinostat with nivolumab {plus minus} ipilimumab in advanced solid tumors. Experimental Design: Patients received an entinostat…

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    • Novel combinations to overcome resistance to #immunotherapy urgently required to improve patient outcome. This phase 1 trial bridges areas of expertise @hopkinskimmel- #epigenetics #immunotherapy #clinicaltrials. https://t.co/X0mVgB8jka