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Mashup Score: 4Targeting TFAM downregulation mediated mtDNA-NLRP3 pathway suppresses TAM infiltration and HCC progression - 16 day(s) ago
Oncogene – Targeting TFAM downregulation mediated mtDNA-NLRP3 pathway suppresses TAM infiltration and HCC progression
Source: www.nature.comCategories: General Medicine NewsTweet
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Mashup Score: 5NRF2-mediated persistent adaptation of oesophageal adenocarcinoma cells to HER2 inhibition - 24 day(s) ago
Oncogene – NRF2-mediated persistent adaptation of oesophageal adenocarcinoma cells to HER2 inhibition
Source: www.nature.comCategories: General Medicine NewsTweet-
A new promising therapeutic strategy for treating refractory #OesophagealCancer by targeting the NRF2 pathway in combination with receptor tyrosine kinase inhibition https://t.co/cwXzVDEnKj #OpenAccess
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Mashup Score: 5
Oncogene – SFXN1 promotes bladder cancer metastasis by restraining PINK1-dependent mitophagy
Source: www.nature.comCategories: General Medicine NewsTweet-
A new insight into the association between #mitophagy and #BladderCancer progression. https://t.co/OXPTfEAzAm #OpenAccess
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Mashup Score: 2Drug tolerance and persistence to EGFR inhibitor treatment are mediated by an ILK-SFK-YAP signaling axis in lung adenocarcinoma - 1 month(s) ago
Oncogene – Drug tolerance and persistence to EGFR inhibitor treatment are mediated by an ILK-SFK-YAP signaling axis in lung adenocarcinoma
Source: www.nature.comCategories: General Medicine NewsTweet-
New study by @BCCancer researchers identifies integrin-linked kinase (ILK) as a key driver of EMT-mediated resistance to EGFR-TKI therapy in lung #cancer. Targeting ILK, limits drug-tolerant persister cell viability. Read more 🔗 https://t.co/QItRE9fibV
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Mashup Score: 3
Oncogene – m6A modification-dependent upregulation of WNT2 facilitates M2-like macrophage polarization and perpetuates malignant progression of nasopharyngeal carcinoma
Source: www.nature.comCategories: General Medicine NewsTweet-
New research reveals that WNT2, upregulated by m6A modification, promotes M2-like macrophage polarization and the malignant progression of nasopharyngeal carcinoma (NPC). Find more about it by reading > https://t.co/2tvGPSW3v4
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Mashup Score: 3
Oncogene – PAR1 inhibition sensitizes HPV-negative HNSCC cells to ferroptosis through inhibition of the STAT3-mediated regulation of iron and lipid metabolic pathways
Source: www.nature.comCategories: General Medicine NewsTweet-
New study shows that downregulating PAR1 enhances the effectiveness of Erastin in treating HPV-negative HNSCC by regulating key ferroptosis-related genes and inhibiting the STAT3 pathway. Read more 🔗 https://t.co/GxDK92Ysoo
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Mashup Score: 4
Oncogene – Functional mitochondrial respiration is essential for glioblastoma tumour growth
Source: www.nature.comCategories: General Medicine NewsTweet-
Recent findings reveal that functional mitochondrial respiration, facilitated by astrocyte-derived mitochondria, is crucial for glioblastoma growth in vivo, supporting coenzyme Q redox cycling and de novo pyrimidine biosynthesis. Read now: https://t.co/7OzPX6aJ3A
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Mashup Score: 11
Oncogene – The deubiquitination-PARylation positive feedback loop of the USP10-PARP1 axis promotes DNA damage repair and affects therapeutic efficacy of PARP1 inhibitor
Source: www.nature.comCategories: General Medicine NewsTweet-
Exciting new insights into DNA damage repair! 🧬 Researchers uncover how USP10 stabilizes PARP1, forming a positive feedback loop that enhances repair mechanisms. Read more > https://t.co/fd8DBKUxEG
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Mashup Score: 14β-Catenin interacts with canonical RBPs including MSI2 to associate with a Wnt signalling mRNA network in myeloid leukaemia cells - 2 month(s) ago
Oncogene – β-Catenin interacts with canonical RBPs including MSI2 to associate with a Wnt signalling mRNA network in myeloid leukaemia cells
Source: www.nature.comCategories: General Medicine NewsTweet-
A new study from @RhysMorganLab @Sussex_BCR shows potential post-transcriptional roles for beta-catenin in myeloid #leukaemia cells. Beta-catenin interacts with a Wnt signalling mRNA network through canonical RNA-binding proteins (RBP) like MSI2. https://t.co/Buso9IEofu
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Mashup Score: 6
Oncogene – FLT1-enriched extracellular vesicles induce a positive feedback loop between nasopharyngeal carcinoma cells and endothelial cells to promote angiogenesis and tumour metastasis
Source: www.nature.comCategories: General Medicine NewsTweet-
Did you know that #ExtracellularVesicles play an important role in #NasopharyngealCarcinoma? https://t.co/GqrH19z4mz
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A novel mechanism by which cytosolic #mtDNA stress mediates TAM infiltration in #HepatocellularCarcinoma https://t.co/C5jpYJb9sZ