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Mashup Score: 279
Chimeric antigen receptor (CAR) T cell therapies have transformed treatment of B cell malignancies. However, their broader application is limited by complex manufacturing processes and the necessity for lymphodepleting chemotherapy, restricting patient …
Source: www.science.orgCategories: General Medicine News, Future of MedicineTweet
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Mashup Score: 267
Chimeric antigen receptor (CAR) T cell therapies have transformed treatment of B cell malignancies. However, their broader application is limited by complex manufacturing processes and the necessity for lymphodepleting chemotherapy, restricting patient …
Source: www.science.orgCategories: General Medicine News, Future of MedicineTweet-
CD8-targeted lipid nanoparticles carrying anti-CD19 CAR mRNA were developed to generate CAR-T cells directly in vivo, demonstrating effective B cell depletion for potential treatment of B cell malignancies and autoimmune diseases. https://t.co/7wq1PmXQqo #NBThighlight
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Mashup Score: 57
Defining viral proteomes is crucial to understanding viral life cycles and immune recognition but the landscape of translated regions remains unknown for most viruses. We have developed massively parallel ribosome profiling (MPRP) to determine open …
Source: www.science.orgCategories: General Medicine News, Future of MedicineTweet-
Massively parallel ribosome profiling allows the investigation of open reading frames in viral sequences, a tool that could be used to expand the repertoire of vaccine targets https://t.co/URg3hPzsY0 #NBThighlight
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Mashup Score: 6Infant receives the first customized CRISPR therapy - 18 day(s) ago
Nature Biotechnology – Infant receives the first customized CRISPR therapy
Source: www.nature.comCategories: General Medicine News, Future of MedicineTweet-
Research Highlight: Infant receives the first customized CRISPR therapy https://t.co/nUor3gJz7u
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Mashup Score: 24Organoid culture promotes dedifferentiation of mouse myoblasts into stem cells capable of complete muscle regeneration - 19 day(s) ago
Nature Biotechnology – Mouse stem cells that regenerate muscle are derived by organoid dedifferentiation of myoblasts.
Source: www.nature.comCategories: General Medicine News, Future of MedicineTweet-
Mouse stem cells that regenerate muscle are derived by organoid dedifferentiation of myoblasts https://t.co/5Vjk7vdSvs https://t.co/c2P4aMrB6A
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Mashup Score: 9New tool improves the detection of hidden genetic mutations - 19 day(s) ago
The tool, described in Nature Biotechnology, will help understand how changes in our DNA affect proteins and ultimately contribute to cancer, neurodegenerative diseases, and other conditions.
Source: www.uclahealth.orgCategories: General Medicine News, Future of MedicineTweet-
@dgsomucla @UCLAHealth @UCLAHealthJCCC @uoftmedicine @PMResearch_UHN @VectorInst @TheBoutrosLab @KislingerThomas @Chenghao_Zhu New tool improves the detection of hidden genetic mutations #NBTIntheNews via @UCLAHealth https://t.co/20AbE1jXXm
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Mashup Score: 32Court reignites CRISPR patent dispute - 19 day(s) ago
Nature Biotechnology – Court reignites CRISPR patent dispute
Source: www.nature.comCategories: General Medicine News, Future of MedicineTweet-
In Brief: @UofCalifornia and @univienna convince US appeals court to revive their bid for patent rights to the CRISPR–Cas9 gene-editing technology created by Jennifer Doudna and Emmanuelle Charpentier https://t.co/UfKo06QfkD https://t.co/YhqHPmi5xj
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Mashup Score: 41Rapid generation of functional vascular organoids via simultaneous transcription factor activation of endothelial and mural lineages - 20 day(s) ago
Melero-Martin and colleagues developed a rapid method to generate vascular organoids from human iPSCs by orthogonally activating the transcription factors ETV2 and NKX3.1. This strategy enabled controlled co-differentiation of vascular cells and supported in vivo engraftment, offering a versatile platform for vascular biology, tissue engineering, and regenerative medicine.
Source: www.cell.comCategories: General Medicine News, Future of MedicineTweet-
Vascular organoids promote revascularization of ischemic muscle and pancreatic islet transplantation in mice https://t.co/u9p7FC1zZF #NBThighlight
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Mashup Score: 7Go fund a brain gain - 20 day(s) ago
Nature Biotechnology – The gutting of US research funding represents a once-in-a-generation opportunity for Europe to boost world-class research deprioritized by the Trump administration.
Source: www.nature.comCategories: General Medicine News, Future of MedicineTweet-
Go fund a brain gain The gutting of US research funding represents a once-in-a-generation opportunity for Europe to boost world-class research deprioritized by the Trump administration https://t.co/wAtf4XIgp6 https://t.co/yEWIwRlGWW
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Mashup Score: 93Identification of non-canonical peptides with moPepGen - 20 day(s) ago
Nature Biotechnology – moPepGen enables the detection of peptides across species, proteases and technologies.
Source: www.nature.comCategories: General Medicine News, Future of MedicineTweet-
Identification of non-canonical peptides with moPepGen https://t.co/dibHWrSI7G https://t.co/Yx8n45mIsu
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CD8-targeted lipid nanoparticles carrying anti-CD19 CAR mRNA were developed to generate CAR-T cells directly in vivo, demonstrating effective B cell depletion for potential treatment of B cell malignancies and autoimmune diseases. https://t.co/7wq1PmXQqo #NBThighlight