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Mashup Score: 0
The C5a receptor inhibitor avacopan is being studied for the treatment of antineutrophil cytoplasmic antibody (ANCA)–associated vasculitis. In this randomized, controlled trial, we assigned patient…
Source: www.nejm.orgCategories: General Medicine NewsTweet
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Mashup Score: 1Adult appendicitis score versus Alvarado score: A comparative study in the diagnosis of acute appendicitis - 3 day(s) ago
Acute Appendicitis (AA) is the most common abdominal surgical emergency. It requires proper management to decrease mortality and morbidity. Clinical scoring systems for diagnosing AA aimed to decrease the use of radiological scans and the rate of …
Source: pmc.ncbi.nlm.nih.govCategories: General Medicine NewsTweet
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Mashup Score: 2Alvarado score - 3 day(s) ago
The Alvarado score is a 10 point score for predicting acute appendicitis (mnemonic MANTRELS). Alfredo Alvarado in 1986
Source: litfl.comCategories: General Medicine NewsTweet
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Mashup Score: 0The Alvarado score for predicting acute appendicitis: a systematic review - BMC Medicine - 3 day(s) ago
Background The Alvarado score can be used to stratify patients with symptoms of suspected appendicitis; the validity of the score in certain patient groups and at different cut points is still unclear. The aim of this study was to assess the discrimination (diagnostic accuracy) and calibration performance of the Alvarado score. Methods A systematic search of validation studies in Medline, Embase, DARE and The Cochrane library was performed up to April 2011. We assessed the diagnostic accuracy of the score at the two cut-off points: score of 5 (1 to 4 vs. 5 to 10) and score of 7 (1 to 6 vs. 7 to 10). Calibration was analysed across low (1 to 4), intermediate (5 to 6) and high (7 to 10) risk strata. The analysis focused on three sub-groups: men, women and children. Results Forty-two studies were included in the review. In terms of diagnostic accuracy, the cut-point of 5 was good at ‘ruling out’ admission for appendicitis (sensitivity 99% overall, 96% men, 99% woman, 99% children). At the
Source: bmcmedicine.biomedcentral.comCategories: General Medicine NewsTweet
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Mashup Score: 0
The American Diabetes Association (ADA) “Standards of Care in Diabetes” includes the ADA’s current clinical practice recommendations and is intended to pro
Source: diabetesjournals.orgCategories: General Medicine NewsTweet
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Mashup Score: 476Thomas (@rx) on X - 4 day(s) ago
working at the intersection between tech and two wheeled things
Source: twitter.comCategories: General Medicine NewsTweet
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Mashup Score: 2Perioperative management of the vulnerable and failing right ventricle - Perioperative Medicine - 5 day(s) ago
Under recognition combined with suboptimal management of right ventricular (RV) dysfunction and failure is associated with significant perioperative morbidity and mortality. The contemporary perioperative team must be prepared with an approach for early recognition and prompt treatment. In this review, a consensus-proposed scoring system is described to provide a pragmatic approach for expeditious decision-making for these complex patients with a vulnerable RV. Importantly, this proposed scoring system incorporates the context of the planned surgical intervention. Further, as the operating room (OR) represents a unique environment where patients are susceptible to numerous insults, a practical approach to anesthetic management and monitoring both in the OR and in the intensive care unit is detailed. Lastly, an escalating approach to the management of RV failure and options for mechanical circulatory support is provided.
Categories: General Medicine NewsTweet
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Mashup Score: 1
Background The right ventricle (RV) plays a central role in the maintenance of effective cardiac pump function. Despite overwhelming evidence that perioperative RV dysfunction (RVD) and failure (RVF) are associated with poor clinical outcomes, there are very few published recommendations or guidelines for comprehensive, evidence-based RV assessment on the risk of developing either during the perioperative period. Main text To address this gap, the Perioperative Quality Initiative-IX (POQI-IX) investigators group, comprised of clinical experts in anesthesiology, cardiovascular surgery, internal medicine, critical care medicine, and advanced practice nursing, has developed a consensus statement based on current literature, published society recommendations, and the clinical expertise of the group. Herein, the group provides recommendations and evidence-based tools related to perioperative RV assessment, functional screening, staging, and the clinical implications of each. These assessmen
Categories: General Medicine NewsTweet
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Mashup Score: 0Medical, Societal, and Ethical Considerations for Directed Blood Donation in 2025 | Annals of Internal Medicine - 7 day(s) ago
In the United States and other high-income countries, blood donation primarily relies on anonymous, voluntary donors. However, directed blood donation—where people donate for a specific recipient—has resurged, particularly due to misinformation surrounding COVID-19 vaccination. Requests for “nonvaccinated” blood, driven by misconceptions about vaccine safety, have led to legislative attempts to mandate compliance. Historically, directed donation was used to mitigate the risk for transfusion-related infections before modern screening techniques rendered it largely unnecessary. Today, it presents important patient safety risks, including increased infectious disease transmission, immunologic complications, and logistic burdens. Directed donations also introduce inefficiencies, diverting resources from the community blood supply and exacerbating shortages. Moreover, directed donation for nonmedical indications lacks scientific justification. Blood safety is ensured through rigorous donor
Source: www.acpjournals.orgCategories: General Medicine NewsTweet
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Mashup Score: 476Thomas (@rx) on X - 7 day(s) ago
working at the intersection between tech and two wheeled things
Source: twitter.comCategories: General Medicine NewsTweet
Avacopan for the Treatment of ANCA-Associated Vasculitis | New England Journal of Medicine - Using it for the first time today! https://t.co/BMLlj1fXyA