A local male in his mid-40s had a 10-year history of pain over both clavicles and sternoclavicular joints. In May 2023, he visited the outpatient rheumatology clinic where physical examination demonstrated enlarged clavicles (Figure 1A) (arrows) but no cutaneous manifestations. Laboratory tests disclosed elevated erythrocyte sedimentation rate (84 mm/h; reference, <16 mm/h), increased C-reactive protein levels (113 mg/L; reference, <8 mg/L), absent human leucocyte antigen-B27, and negative culture results.

To examine the association of “weekend warrior” (WW) pattern and physical activity distributed throughout the week with mortality risk.

This 2-cm mass was identified in the second portion of the duodenum in an adult. Pathologic examination diagnosed the tumor as a composite gangliocytoma/neuroma and neuroendocrine tumor (CoGNET).

Risk stratification for transcatheter aortic valve replacement (TAVR) uses risk scores derived solely from clinical variables. However, there is growing recognition of the potential role of incorporating anatomic features in predicting clinical outcomes after the procedure.1,2 A recent study suggests that an angulated aortic arch may adversely affect aortic hemodynamics and the risk of type B aortic dissection.3,4

A 28-year-old woman presented to the neurology outpatient clinic reporting a 2-year history of spells that were initially occurring once weekly and lasting 15 to 30 minutes with no identifiable triggers. Symptoms experienced during the episodes included palpitations, lightheadedness, hyperhidrosis, irritability, generalized weakness, dissociation, and difficulty understanding and speaking. Abnormal motor activity was not reported. The spells initially resolved with food intake; however, this became less consistent over time.

An adult male who had chronic myelomonocytic leukemia was evaluated for 3 months of hemorrhagic bullae on the hands. Empiric antimicrobial therapy with linezolid, Bactrim, and isavuconazole had provided minimal relief. Physical examination revealed plaques with necrotic crust overlying the metacarpo- and proximal interphalangeal joints with surrounding desquamation and violaceous borders (Figure 1). No other cutaneous or mucosal involvement was present. He had a leukocytosis of 45,500/μL with a manual absolute neutrophil count of 41,000/μL.

The number of highly sensitized patients in need of a multiorgan transplant is increasing. Criteria informing their transplant candidacy, approaches to management on the waitlist, and protocols related to alloantibody monitoring vary widely. We convened a consensus conference to discuss these different practices in the United States and the United Kingdom and to review the contemporary outcomes of these challenging cases. A detailed analysis of the data regarding the liver allografts’ immunoprotective effect on simultaneously transplanted other organs was also completed, and the prospect of the use of liver allografts primarily to facilitate transplantation of highly sensitized patients in need of other organs was discussed.