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Mashup Score: 1
1. Always promotes the mission of the Knight Cardiovascular Institute through our Professional Standards of timely Customer Service, Reliability, Productivity, Professionalism, Accuracy, Timeliness, Integrity, and Problem-Solving. 2. Responsible for the lifecycle of bio samples while in the CTU from collection to shipping. This includes but is not limited to: – Works in collaboration with study coordinator to maintain and file regulatory and study documents of all samples collected for various studies. – Keeps detailed accounting records of all samples processed, shipped, and stored. – Creates and maintains a database of all bio samples in cryostorage. – Processes samples after collection and prepares for shipping. – Prepare, finalize, and deliver all packages for shipment at days end. – Maintaining laboratory reporting and signature requests from the PI . 3. Benchtop research for investigator initiated clinical trials, including but not limited to: – Perform various molecular techn
Source: externalcareers-ohsu.icims.comCategories: General Medicine NewsTweet
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Mashup Score: 55Early Detection of Transthyretin Cardiac Amyloidosis Using 124I-Evuzamitide Positron Emission Tomography/Computed Tomography: - 16 day(s) ago
AbstractBackgroundEarly detection of transthyretin cardiac amyloidosis (ATTR-CA) is vital, because currently available therapies are most effective early in the disease course. Although Perugini gr…
Source: www.jacc.orgCategories: General Medicine NewsTweet
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Mashup Score: 37Sotatercept in Patients with Pulmonary Arterial Hypertension at High Risk for Death | NEJM - 18 day(s) ago
Sotatercept improves exercise capacity and delays the time to clinical worsening in patients with World Health Organization (WHO) functional class II or III pulmonary arterial hypertension. The eff…
Source: www.nejm.orgCategories: General Medicine NewsTweet
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Mashup Score: 70A Multicenter Study of Contemporary Long-Term Tafamidis Outcomes in Transthyretin Amyloid Cardiomyopathy - PubMed - 18 day(s) ago
In a contemporary cohort of tafamidis-treated patients with ATTR-CM, 39% of patients died over a median of 43 months. Further work is needed to improve our understanding of ATTR-CM, its natural history, and how to further improve survival and prevent progression of heart failure.
Source: pubmed.ncbi.nlm.nih.govCategories: General Medicine NewsTweet
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Mashup Score: 5Expert Insights Into Amyloidosis: Do You Need a Heart Biopsy to Diagnose Cardiac Amyloidosis? - 19 day(s) ago
Dr. Ahmad Masri, Director of the Cardiac Amyloidosis Program at Oregon Health & Science University (OHSU), reminds us about the traditional approach to diagn…
Source: www.youtube.comCategories: General Medicine NewsTweet
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Mashup Score: 30Impact of Heart Failure Severity on Vutrisiran Efficacy in Transthyretin Amyloidosis With Cardiomyopathy: - 22 day(s) ago
AbstractBackgroundVutrisiran reduced the risk of all-cause mortality (ACM) and recurrent cardiovascular (CV) events in patients with transthyretin amyloidosis with cardiomyopathy (ATTR-CM) in HELIO…
Source: www.jacc.orgCategories: General Medicine NewsTweet
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Mashup Score: 10Reducing Granules Without Splicing Restoration Alleviates RBM20 Cardiomyopathy | Circulation Research - 26 day(s) ago
BACKGROUND: RBM20 (RNA binding motif protein 20) cardiomyopathy is a severe form of dilated cardiomyopathy (DCM). Genetic variants in the nuclear localization signal of Rbm20 hinder its nuclear import and promote cytoplasmic pathogenic RNP (ribonucleoprotein) granules. We aimed to investigate whether reducing RNP granules by inhibiting Rbm20 expression could alleviate the DCM phenotype in Rbm20 S639G (Rbm20S639G) knock-in mice. METHODS: We downregulated Rbm20, utilizing antisense oligonucleotides (ASOs) that specifically inhibit Rbm20 expression. We administered Rbm20-ASOs in Rbm20S639G mice that carry a serine-to-glycine substitution in the nuclear localization signal of RBM20. The Rbm20-ASOs were administered subcutaneously at 25 mg/kg once a week for 8 weeks in both young (14-day-old) mice before the onset of DCM and adult (3-month-old) mice with established DCM phenotype. In vivo cardiac function was assessed by echocardiography. RNP granules were identified through fluorescent imm
Source: www.ahajournals.orgCategories: General Medicine NewsTweet
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Mashup Score: 30Impact of Heart Failure Severity on Vutrisiran Efficacy in Transthyretin Amyloidosis With Cardiomyopathy: - 28 day(s) ago
AbstractBackgroundVutrisiran reduced the risk of all-cause mortality (ACM) and recurrent cardiovascular (CV) events in patients with transthyretin amyloidosis with cardiomyopathy (ATTR-CM) in HELIO…
Source: www.jacc.orgCategories: General Medicine NewsTweet
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Mashup Score: 32Cardiopulmonary exercise testing parameters in healthy athletes vs. equally fit individuals with hypertrophic cardiomyopathy - 1 month(s) ago
AbstractAims. Cardiopulmonary exercise testing (CPET) is often used when athletes present with suspected hypertrophic cardiomyopathy (HCM). While low peak
Source: academic.oup.comCategories: General Medicine NewsTweet
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Mashup Score: 39Myocardium From Patients With ATTR Amyloidosis Produces Less Force Secondary to Increased Fibrosis: - 1 month(s) ago
Highlights •Cardiac amyloidosis is an infiltrative cardiomyopathy that results in wall thickening and diastolic dysfunction.•Contractile assays, histology, and biochemical assays were performed on …
Source: www.jacc.orgCategories: General Medicine NewsTweet
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