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    • Mashup Score: 111
      Ultrasensitive plasma-based monitoring of tumor burden using machine-learning-guided signal enrichment - 1 year(s) ago

      Nature Medicine – Detection of circulating tumor DNA using MRD-EDGE, a machine-learning-guided single-nucleotide variant and copy-number variant detection platform for signal enrichment, enables…

      Source: www.nature.com
      Categories: General Medicine News, Hem/Oncs
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      • Profile photo of 	landau_lab
        landau_lab

        "Did you know that you don't need targeted panels for ultra-sensitive MRD?" 🥳 Down right ebullient to share our latest 🥳@NatureMedicine ! MRD-EDGE leverages advanced #ML for #WGS #ctDNA detection across clinical context https://t.co/drJasWVwoE #DeepLearning 🪡 https://t.co/mmMIDNQNbE

    • Mashup Score: 111
      Ultrasensitive plasma-based monitoring of tumor burden using machine-learning-guided signal enrichment - 1 year(s) ago

      Nature Medicine – Detection of circulating tumor DNA using MRD-EDGE, a machine-learning-guided single-nucleotide variant and copy-number variant detection platform for signal enrichment, enables…

      Source: www.nature.com
      Categories: General Medicine News, Hem/Oncs
      Tweet Tweets with this article
      • Profile photo of 	landau_lab
        landau_lab

        "Did you know that you don't need targeted panels for ultra-sensitive MRD?" 🥳 Down right ebullient to share our latest 🥳@NatureMedicine ! MRD-EDGE leverages advanced #ML for #WGS #ctDNA detection across clinical context https://t.co/drJasWVwoE #DeepLearning 🪡 https://t.co/mmMIDNQNbE

    • Mashup Score: 273
      Genotype-to-phenotype mapping of somatic clonal mosaicism via single-cell co-capture of DNA mutations and mRNA transcripts - 1 year(s) ago

      Somatic mosaicism is a hallmark of malignancy that is also pervasively observed in human physiological aging, with clonal expansions of cells harboring mutations in recurrently mutated driver genes. Bulk sequencing of tissue microdissection captures mutation frequencies, but cannot distinguish which mutations co-occur in the same clones to reconstruct clonal architectures, nor phenotypically profile clonal populations to delineate how driver mutations impact cellular behavior. To address these challenges, we developed single-cell Genotype-to-Phenotype sequencing (scG2P) for high-throughput, highly-multiplexed, single-cell joint capture of recurrently mutated genomic regions and mRNA phenotypic markers in cells or nuclei isolated from solid tissues. We applied scG2P to aged esophagus samples from five individuals with high alcohol and tobacco exposure and observed a clonal landscape dominated by a large number of clones with a single driver event, but only rare clones with two driver mu

      Source: www.biorxiv.org
      Categories: General Medicine News, Oncologists1
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      • Profile photo of 	landau_lab
        landau_lab

        🍭new pre-print! In collab. with @MissionBio , we developed single-cell Genotype-to-Phenotype (scG2P) for targeted co-capture of DNA & mRNA! We explore esophagus clonal mosaicism, defining clonal structure the phenotypic impact of somatic drivers https://t.co/WEwmJwnOO4 https://t.co/PlEGx1g4xW

    • Mashup Score: 283
      Single-cell genotype-phenotype mapping identifies therapeutic vulnerabilities in VEXAS syndrome - 1 year(s) ago

      Somatic evolution leads to the emergence of clonal diversity across tissues with broad implications for human health. A striking example of somatic evolution is the VEXAS (Vacuoles E1 enzyme X-linked Autoinflammatory Somatic) syndrome, caused by somatic UBA1 mutations in hematopoietic stem cells (HSCs), inducing treatment-refractory, systemic inflammation. However, the mechanisms that lead to survival and expansion of mutant HSCs are unknown, limiting the development of effective therapies. The lack of animal or cellular models of UBA1-mutant HSCs has hindered such mechanistic understanding, mandating analysis of primary human VEXAS samples, which harbor admixtures of wild-type and UBA1-mutant HSCs. To address these challenges, we applied single-cell multi-omics to comprehensively define mutant UBA1-induced transcriptome, chromatin accessibility and signaling pathway alterations in VEXAS patients, allowing for the direct comparison of mutant versus wild-type cells within the same envir

      Source: www.biorxiv.org
      Categories: General Medicine News, Oncologists1
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      • Profile photo of 	landau_lab
        landau_lab

        🥳new pre-print alert! VEXAS syndrome deciphered - From single-cell genotype-to-phenotype mapping aaaall the way to mechanism and therapeutic vulnerability discovery! https://t.co/aeq47hzZ0w

    • Mashup Score: 47
      Mapping genotypes to chromatin accessibility profiles in single cells - 1 year(s) ago

      Nature – The JAK2V617F mutation leads to epigenetic rewiring in a cell-intrinsic and cell-type-specific manner, influencing inflammation states and differentiation trajectories in patients with…

      Source: link.springer.com
      Categories: General Medicine News, Hem/Oncs
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      • Profile photo of 	landau_lab
        landau_lab

        Also a link to @nature for this work: https://t.co/36E1WoGf0G We have already helped ~15 labs get going on GoT-ChA, ping us if we can be of any help https://t.co/VIF4WqiLSM

    • Mashup Score: 18
      How to Be Less Harsh with Yourself (and Others): Ram Dass on the Spiritual Lessons of Trees - 2 year(s) ago

      A simple perspective shift that reorients the roots of being.

      Source: www.themarginalian.org
      Categories: General Medicine News, Hem/Oncs
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      • Profile photo of 	landau_lab
        landau_lab

        RT @brainpicker: Ram Dass on what trees teach us about being less harsh on ourselves (and on others) https://t.co/FqVHlD1q4l

    • Mashup Score: 4
      Israel screens unseen Hamas bodycam footage of attack - 2 year(s) ago

      Journalists were shown 43 minutes of raw footage from the attack but most of it will not be made public.

      Source: www.bbc.co.uk
      Categories: General Medicine News, Hem/Oncs
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      • Profile photo of 	landau_lab
        landau_lab

        Israel shows Hamas bodycam attack footage to journalists https://t.co/Xyqw7soGkA https://t.co/9gT4zs69FF

    • Mashup Score: 30
      Single-cell multi-omics defines the cell-type-specific impact of splicing aberrations in human hematopoietic clonal outgrowths - 2 year(s) ago

      RNA splicing factors are recurrently mutated in clonal blood disorders, but the impact of dysregulated splicing in hematopoiesis remains unclear. To o…

      Source: www.sciencedirect.com
      Categories: Hem/Oncs, Latest Headlines
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      • Profile photo of 	landau_lab
        landau_lab

        ✂️Splice splice baby!✂️ New paper just out in @CellStemCell integrating @nanopore long read single-cell isoform mapping into our broader genotype-phenotype vision for clonal mosaicism ! https://t.co/2VmlsWiOGG https://t.co/1cdA9ZwWU3

    • Mashup Score: 4
      Sign the Petition - 2 year(s) ago

      Eliminate ABIMs MOC requirement

      Source: www.change.org
      Categories: Latest Headlines, Oncologists1
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      • Profile photo of 	landau_lab
        landau_lab

        RT @yarongesty: Eliminate ABIMs MOC requirement - Sign the Petition! https://t.co/bwSnYTiFax via @Change

    • Mashup Score: 36
      NIH launches $140 million effort to investigate genetic variation in normal human cells and tissues - 2 year(s) ago

      Common Fund Program will accelerate research on human development, aging, and disease.

      Source: National Institutes of Health (NIH)
      Categories: Hem/Oncs, Latest Headlines
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      • Profile photo of 	landau_lab
        landau_lab

        This is the day! NIH announced a common fund initiative for somatic mosaicism! Super excited to join a absolutely dreamy group of ultra smaht scientists ...be still my beating heart...:) https://t.co/LarsTVEwsP

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    Dan Landau

    @landau_lab

    Cancer genomics, epigenomics and evolutionary dynamics (Weill Cornell/New York Genome Center). Hemato-oncologist (NYP). Discl.: https://t.co/tAu87FMVW3

    ASCO 2025

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