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Mashup Score: 8IgG4-Related Arterial Disease: An Unusual Case of Aortitis - 2 day(s) ago
IgG4-related disease is a multiorgan immune-mediated condition that mimics many malignant, infectious, and inflammatory disorders. The most frequently affected site of IgG4-related vascular disorder is the abdominal aorta, which presents as an aortic aneurysm.1 Here, we report a case involving thoracic aorta involvement in a patient who has been suffering from unexplained pain and an inflammatory syndrome for the past 10 years. A 51-year-old female patient had been experiencing …
Source: www.jrheum.orgCategories: General Medicine News, RheumatologyTweet
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Mashup Score: 3Improving Systemic Sclerosis Quality of Care - 3 day(s) ago
Objective Systemic sclerosis (SSc) is a multisystemic autoimmune disease with high morbidity and healthcare costs. Inconsistent quality of care delivery, including inadequate screening and monitoring, necessitates improvement. This study aimed to enhance the uptake of validated quality indicators (QIs) for SSc. Methods An interrupted time series study was conducted at 4 scleroderma clinics across 2 hospitals using the Model for Improvement methodology, employing Plan-Do-Study-Act (PDSA) cycles. A retrospective chart review assessed baseline frequencies of selected QIs. The primary aim was to increase rates of 7 baseline and 5 follow-up QIs to 80%. Root-cause analysis identified barriers to QI uptake, leading to interventions including provider education, equipment procurement, and care standardization with reminder systems. Real-time data tracking was facilitated through run charts. Results The average completion rate for baseline QIs increased from 48% to 83% over 8 months, with susta
Source: www.jrheum.orgCategories: General Medicine News, RheumatologyTweet-
Research Article Improving Systemic Sclerosis Quality of Care 📖 https://t.co/Sks52C0SpU @AboabatAos @SindhuJohnson5 @SinaiHealth @SchroederInst #systemicsclerosis #qualityindicators https://t.co/zuNrBHp2ZP
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Mashup Score: 7
Objective We aimed to explore the prevalence of degenerative disc disease (DDD) in patients with psoriatic arthritis (PsA) aged < 50 years and to describe the factors associated with its development. We also examined the association between radiographic axial imaging findings and inflammatory back pain (IBP) and mechanical back pain. Methods We included patients with PsA aged < 50 years who were followed at our prospective observational cohort. We defined DDD as intervertebral disc space narrowing, spur formation, facet joint arthrosis, and spondylolisthesis on anteroposterior and lateral plain radiographs of the cervical and thoracolumbar spine. To identify factors associated with the development of DDD, we used multivariate Cox regression analysis. We used generalized estimating equations (GEEs) to test the association between imaging findings (isolated DDD, isolated axial disease, and both) and the type of back pain. Results Of 814 patients included in the study, 316 (38.8%) were ob
Source: www.jrheum.orgCategories: General Medicine News, RheumatologyTweet-
Research Article Degenerative Disc Disease in Young Adults With Psoriatic Arthritis 📖 https://t.co/LPtIZasp37 @SchroederInst @KBI_UHN @UofTRheum #degenerativediscdisease #psoriaticarthritis https://t.co/GMWgyj3EsW
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Mashup Score: 5
Objective In patients with axial spondyloarthritis (axSpA) initiating secukinumab (SEC), we aimed to identify baseline (treatment start) predictors of achieving low disease activity (LDA) after 6 months, as measured by the Axial Spondyloarthritis Disease Activity Score using C-reactive protein (ASDAS-CRP) and Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), as well as treatment continuation after 12 months. Methods From 11 European registries, patients with axSpA who initiated SEC treatment in routine care, with available data on 6-month ASDAS-CRP and BASDAI assessments were included. Logistic regression analyses on multiply imputed baseline data were performed; potential baseline predictors included demographic, diagnosis, lifestyle, clinical, and patient-reported variables. Results In a pooled cohort of 1174 patients with axSpA, 5 of 19 potential assessed variables were mutually predictive for achieving LDA by ASDAS-CRP and BASDAI: higher physician global assessment score
Source: www.jrheum.orgCategories: General Medicine News, RheumatologyTweet-
Research Article Predictors of Secukinumab Treatment Response and Continuation in Axial Spondyloarthritis: Results From the EuroSpA Research Collaboration Network 📖 https://t.co/HmmFqW5Aff @Rigshospitalet #epidemiology #spondyloarthritis https://t.co/JLRv6MF3fn
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Mashup Score: 1Sex Differences in Rheumatoid Arthritis: New Insights From Clinical and Patient-Reported Outcome Perspectives - 6 day(s) ago
Objective The disease course and burden of rheumatoid arthritis (RA) may differ between female and male individuals, but existing data on these differences are limited and often contradictory. Therefore, we investigated whether clinical outcomes and patient-reported outcomes (PROs) differ between female and male patients with RA over time. Methods All female (n = 286) and male (n = 139) patients with RA according to 1987 and/or 2010 criteria from Treatment in the Rotterdam Early Arthritis Cohort (tREACH), a stratified single-blinded trial with a treat-to-target (T2T) approach and fixed medication protocol, were included. Clinical outcomes include disease activity, medication usage, sustained disease-modifying antirheumatic drug (DMARD)-free remission (SDFR), and radiographic progression. In addition, the following PROs were investigated: general health, pain, functional ability, health-related quality of life, fatigue, productivity loss, and a possible depression or anxiety disorder. F
Source: www.jrheum.orgCategories: General Medicine News, RheumatologyTweet-
Research Article Sex Differences in Rheumatoid Arthritis: New Insights From Clinical and Patient-Reported Outcome Perspectives 📖 https://t.co/F2yctCIdbH @antrebea @ErasmusMC #patientoutcomes #rheumatoidarthritis https://t.co/fMcCQ1lf3h
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Mashup Score: 5Healthcare Utilization and Cost of Herpes Zoster Infection in Patients With Rheumatoid Arthritis: A Retrospective Cohort Study - 9 day(s) ago
Objective Patients with rheumatoid arthritis (RA) have an increased risk of developing herpes zoster (HZ) compared to the general population. We aimed to measure healthcare utilization (HCU) and related costs of HZ among patients with RA, from the public payer’s perspective. Methods Adult patients with RA diagnosed with HZ between 2008 and 2020 were matched by sex, age, and date of HZ infection to (1) patients with RA without HZ, (2) the non-RA population with HZ, and (3) the non-RA population without HZ. Unadjusted gamma distribution models and generalized estimating equations were used to compare HCU costs and the number of clinical events (CEs), including hospital admissions and emergency department and physician visits, in patients with RA with HZ to each matched cohort. Results We identified 15,573 patients with RA diagnosed with HZ and a similar number for each of the 3 matched cohorts. From year 1 to year 10, mean total cost ranged from CAD $13,507 to CAD $17,120 for the RA with
Source: www.jrheum.orgCategories: General Medicine News, RheumatologyTweet-
Research Article Healthcare Utilization and Cost of Herpes Zoster Infection in Patients With Rheumatoid Arthritis: A Retrospective Cohort Study 📖 https://t.co/jGg2qkzNRc @UHN @TGHRI_UHN @ihpmeuoft #healthcareutilization #herpeszoster #rheumatoidarthritis https://t.co/KlIR1QM1F5
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Mashup Score: 6Role of CD19 Chimeric Antigen Receptor T Cell Therapy in Idiopathic Inflammatory Myopathies - 10 day(s) ago
Idiopathic inflammatory myopathies (IIMs) comprise a spectrum of autoinflammatory disease characterized primarily by muscle inflammation, with secondary involvement of diverse organs including joints, skin, lungs, heart, and the gastrointestinal system. Managing these conditions poses considerable challenges, often inflicting profound distress on the afflicted individuals. Encouragingly, the deployment of chimeric antigen receptor (CAR) T cell therapy has demonstrated promising efficacy across various autoimmune diseases, extending hope for ameliorating the burden of IIM. This review provides an overview of the role of B cells in IIM pathogenesis, currently available B cell–depleting therapies, reasons for their lack of efficacy, and the application of CD19 CAR T cell therapy in the management of IIM, encompassing indications, efficacy, and tolerability profiles in these patient populations. Through this comprehensive review, we propose clinical trial design, target population, respons
Source: www.jrheum.orgCategories: General Medicine News, RheumatologyTweet-
Review Article Role of CD19 Chimeric Antigen Receptor T Cell Therapy in Idiopathic Inflammatory Myopathies 📖 https://t.co/yJbS7toioX @Anushka2k7 @docrota #TCellTherapy #inflammatorymyopathies https://t.co/NX61A1xtBe
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Mashup Score: 2Correlation Between Interferon Response Gene Score and Disease Activity in Juvenile Dermatomyositis - 11 day(s) ago
Objective Type 1 interferons (IFNs) have been identified as potentially important measures of disease activity in juvenile dermatomyositis (JDM). An IFN response gene (IRG) score has been defined using NanoString technology and appears to correlate with disease activity in cross-sectional samples of patients with JDM. This study aimed to determine if there is evidence of a correlation between disease activity and IRG score in patients with JDM, both early in the disease course and longitudinally. Methods All patients attending the JDM clinic at The Hospital for Sick Children (SickKids), in Toronto, Canada, were approached to enroll in the Childhood Arthritis and Rheumatic Diseases (CARD) biobank. We identified patients with a diagnosis of JDM, enrolled between January 2015 and June 2022. NanoString IRG score was calculated from extracted RNA. The modified Disease Activity Score was calculated based on clinical data collected prospectively through SickKids’s JDM registry. Spearman corre
Source: www.jrheum.orgCategories: General Medicine News, RheumatologyTweet-
Research Article Correlation Between Interferon Response Gene Score and Disease Activity in Juvenile Dermatomyositis 📖 https://t.co/WOKMRqvNyE @SickKidsNews #interferons #juveniledermatomyositis https://t.co/aCSH1eo1vq
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Mashup Score: 1Interferon Response Gene Score in Juvenile Dermatomyositis - 11 day(s) ago
Juvenile dermatomyositis (JDM) is a rare, heterogeneous, inflammatory vasculopathy with primary characteristics in muscle and skin. The disease course is unpredictable. Most patients have a chronic or polycyclic (recurrent flares) disease course.1 Myositis-specific autoantibodies (MSAs) help define clinical subgroups regarding clinical features and disease course.2 Although muscle enzymes (creatine kinase [CK], lactate dehydrogenase, aspartate aminotransferase, alanine aminotransferase, aldolase) are currently used as clinical laboratory biomarkers, they are not always elevated even at diagnosis and may underestimate disease activity, particularly extramuscular disease or low-level inflammation, which may be more difficult to recognize clinically.3 There is a need for better biomarkers to help guide treatment in JDM and avoid persistent or worsening disease, as well as increased damage from chronic inflammation. Multiple transcriptomic studies looking in key tissues (blood, skin, muscl
Source: www.jrheum.orgCategories: General Medicine News, RheumatologyTweet-
Editorial Interferon Response Gene Score in Juvenile Dermatomyositis 📖 https://t.co/4NahU2cmoW @NIH_NIAMS #interferons #juveniledermatomyositis https://t.co/XO2cnm8P0m
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Mashup Score: 10
Objective To assess the effect of increasing age on the frequency of inflammatory and structural magnetic resonance imaging (MRI) lesions in the sacroiliac joints (SIJ) in 3 independent cohorts of healthy individuals and patients with nonspecific back pain (NSBP). Methods We assessed MRI SIJ lesions in 3 cohorts (A, B, and C) of healthy individuals (cohort A, n = 79; cohort B, n = 78) and patients with NSBP (cohort A, n = 87; cohort C, n = 46) aged ≤ 45 years referred with back pain suspicious of axial spondyloarthritis (axSpA). MRI lesions were recorded on consecutive slices in SIJ quadrants or halves through the cartilaginous SIJ. Lesions were ascertained by 2-7 central readers according to standardized lesion definitions. Lesions recorded concordantly by the majority of readers were analyzed according to age categories (18-29, 30-39, and 40-50 yrs) and previously reported data-driven MRI cutoffs indicative of inflammatory or structural lesions typical of axSpA. Results Only 3.8% (in
Source: www.jrheum.orgCategories: General Medicine News, RheumatologyTweet-
Research Article Effect of Age on Active and Structural Magnetic Resonance Imaging Lesions in Sacroiliac Joints of Healthy Individuals and Patients With Nonspecific Back Pain 📖 https://t.co/XPjUav46lz @pedrommcmachado @XBaraliakos @WalterMaks #backpain #sacroiliacjoints https://t.co/8TBHC6uPpN
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Images in Rheumatology IgG4-Related Arterial Disease: An Unusual Case of Aortitis 📖 https://t.co/ZAB7oe1V92 #IgG4 #aortitis https://t.co/DfM0QS1ZJj