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Mashup Score: 2
Objective To evaluate the effect of achieving minimal disease activity (MDA) within the first year on radiologic damage at 3-year follow-up in patients with newly diagnosed psoriatic arthritis (PsA). Methods Data were used from the Dutch southwest Early PsA cohort, a real-world cohort of newly diagnosed patients with PsA, focusing on those with oligoarthritis or polyarthritis. Patients were stratified into 3 groups: (1) sustained MDA, achieving MDA at least at both 9 and 12 months post diagnosis; (2) nonsustained MDA, achieving MDA in the first year but not sustaining it at 9 and 12 months; (3) no MDA, not achieving MDA in the first year. Radiographic assessment was used by the modified Total Sharp/van der Heijde score for PsA. Group comparisons at 3-year follow-up for radiographic changes were conducted using a linear mixed model. Results Two hundred eighty-four patients were categorized into 3 groups: 96 patients (34%) in the sustained MDA group, 83 (29%) in the nonsustained MDA grou
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Mashup Score: 2Cardiometabolic Effects of Apremilast in Patients With Psoriatic Arthritis: A Prospective Cohort Study - 6 day(s) ago
Objective Psoriatic arthritis (PsA) is associated with metabolic and cardiovascular (CV) disease. Studies have suggested that treatment with apremilast is associated with weight loss and other cardiometabolic benefits. This study aimed to examine the effects of apremilast on body weight, body composition, and CV risk factors in patients with PsA. Methods This longitudinal, nonrandomized, multicenter trial included adults with active PsA initiating apremilast (30 mg twice daily after a step-up regimen). Patients were followed for 12 months, and measurements were done at baseline and repeated at weeks 26 and 52. Body composition, the primary outcome, was assessed using dual-energy x-ray absorptiometry. Secondary outcomes included disease activity (Disease Activity Score in 28 joints [DAS28] based on C-reactive protein [CRP]), blood pressure (BP), lipids, intima-media thickness, and glucose. Statistical analysis involved mixed models adjusted for relevant covariates. Results Forty-four pa
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Research Article Cardiometabolic Effects of Apremilast in Patients With Psoriatic Arthritis: A Prospective Cohort Study 📖 https://t.co/iybVYSrFzo @amsterdamumc #cardiovascular #riskfactors #psoriaticarthritis https://t.co/naVgAO5BhE
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Mashup Score: 2Knowledge, Awareness, and Attitudes Regarding Axial Spondyloarthritis Among Nonrheumatology Physicians in the United States - 7 day(s) ago
Objective We surveyed physicians in the United States to assess knowledge, awareness, and attitudes toward axial spondyloarthritis (axSpA). The objective was to identify barriers for referral and opportunities for intervention to reduce diagnostic delay of axSpA. Methods An online questionnaire was distributed nationwide to nonrheumatology physicians (NRPs) serving patients with chronic back pain (CBP), namely in family/internal medicine, spine surgery/orthopedics, pain management, physical medicine/rehabilitation, and to rheumatologists as the comparator group. Results Seven hundred fifty physicians completed the survey (response rate 24%). The majority of NRPs were familiar with inflammatory back pain (IBP); 87% could identify > 4 of 8 IBP items, but only 41% routinely assess for IBP in practice. NRPs screen patients for axSpA risk factors ≤ 50% of the time. NRPs order C-reactive protein and HLA-B27 tests significantly less often, and antinuclear antibodies and rheumatoid factor test
Source: www.jrheum.orgCategories: General Medicine News, RheumatologyTweet-
Research Article Knowledge, Awareness, and Attitudes Regarding Axial Spondyloarthritis Among Nonrheumatology Physicians in the United States 📖 https://t.co/J30DNY1G3w @YaleMed #axialspondyloarthritis #eductaion #physicians https://t.co/nFg5xUsS2w
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Mashup Score: 13
Objective Intermediate treatment targets in Still disease have been proposed by the European Alliance of Associations for Rheumatology (EULAR) and the Paediatric Rheumatology European Society (PReS) in 2024. This study aimed to evaluate the utility of the targets in clinical practice. Methods Consecutive patients with adult-onset Still disease (AOSD) based on the Yamaguchi criteria who visited Keio University Hospital from April 2012 until May 2024 were retrospectively reviewed. We assessed the achievement rates of the following treatment targets: day 7 (resolution of fever and reduction of C-reactive protein [CRP] by > 50%); week 4 (no fever, reduction of active joint count by > 50%, and normal CRP); month 3 (clinically inactive disease [CID] with < 0.1 mg/kg/day of glucocorticoids [GCs]); and month 6 (CID without GCs). We also assessed the association of treatment target achievement with long-term outcomes including recurrence and discontinuation of GCs. Results Sixty-two patients we
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Research Article Achievement and Usefulness of Intermediate Treatment Targets for Still Disease Proposed by @eular_org and @PReSociety_ 📖 https://t.co/S1f8riMiy4 @KeioGlobal #Stilldisease #glucocorticoids #recurrence https://t.co/iS1ClZIK9t
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Mashup Score: 3
Objective To assess whether there is a rural-urban and income-related disparity in the incidence and outcomes of hospitalization for myocardial infarction (MI) in patients with rheumatoid arthritis (RA). Methods We used the 2016-2019 US National Inpatient Sample (NIS) data and selected all patients with RA. Rural vs urban residential status was identified using NIS classifications. We categorized median household income based on patient ZIP code by quartile. We assessed the multivariable-adjusted odds ratios (aORs) to examine the association of rural residence with MI hospitalization. Results The crude rate of MI hospitalization per 100,000 area-specific hospitalizations in people with RA was significantly higher for rural vs urban residents, 2441 vs 1878 ( P < 0.001). In multivariable-adjusted models, compared to urban residents, rural-residing residents with RA were almost twice as likely to be hospitalized with MI (aOR 1.70; P < 0.001). Rural residence was not significantly associat
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Research Article Rural-Dwelling Patients With Rheumatoid Arthritis and Risk of Myocardial Infarction Hospitalization: An Observational Study Using the National Inpatient Sample 📖 https://t.co/OuNkRarggy @UABDeptMed #hospitalization #myocardialinfarction #rheumatoidarthritis https://t.co/J6rLCPUyfr
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Mashup Score: 4Development of an Application for Self-Monitoring to Empower Patients With Rheumatoid Arthritis (MyRA) - 9 day(s) ago
Objective To develop a web-based self-monitoring tool including motivational elements to improve empowerment of patients with rheumatoid arthritis (RA). Methods Following a design-thinking approach, the development included 3 iterative, cocreative phases involving different stakeholders. In the empathize and define phase, 2 focus groups gave insight into patients’ wishes and needs regarding self-monitoring with an application. During the ideation phase, 2 cocreation sessions were organized to establish the content of the application and consider motivational elements. For the prototyping and testing phase, usability was assessed through both formative (heuristics evaluation) and summative (system usability scale [SUS] 0-100; ≥ 68 was considered good to excellent) evaluations. Results The focus group meetings resulted in a shortlist of what to monitor (physical function, quality of life, pain, fatigue, mental well-being, and social participation) and preferences on how to monitor (singl
Source: www.jrheum.orgCategories: General Medicine News, RheumatologyTweet-
Research Article Development of an Application for Self-Monitoring to Empower Patients With Rheumatoid Arthritis (MyRA) 📖 https://t.co/h75hG0a302 #digitalhealth #patients #rheumatoidarthritis https://t.co/BpX2ITKwRv
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Mashup Score: 4Development of an Application for Self-Monitoring to Empower Patients With Rheumatoid Arthritis (MyRA) - 9 day(s) ago
Objective To develop a web-based self-monitoring tool including motivational elements to improve empowerment of patients with rheumatoid arthritis (RA). Methods Following a design-thinking approach, the development included 3 iterative, cocreative phases involving different stakeholders. In the empathize and define phase, 2 focus groups gave insight into patients’ wishes and needs regarding self-monitoring with an application. During the ideation phase, 2 cocreation sessions were organized to establish the content of the application and consider motivational elements. For the prototyping and testing phase, usability was assessed through both formative (heuristics evaluation) and summative (system usability scale [SUS] 0-100; ≥ 68 was considered good to excellent) evaluations. Results The focus group meetings resulted in a shortlist of what to monitor (physical function, quality of life, pain, fatigue, mental well-being, and social participation) and preferences on how to monitor (singl
Source: www.jrheum.orgCategories: General Medicine News, RheumatologyTweet-
Research Article Development of an Application for Self-Monitoring to Empower Patients With Rheumatoid Arthritis (MyRA) 📖 https://t.co/h75hG0a302 #digitalhealth #patients #rheumatoidarthritis https://t.co/BpX2ITKwRv
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Mashup Score: 14Conducting a High-Quality Systematic Review - 9 day(s) ago
Systematic reviews (SRs) are a structured means of knowledge synthesis used by a variety of healthcare practitioners to aid in medical decision making. The SR, if conducted rigorously, is considered to be at the top of the hierarchy for research studies. In addition to synthesizing evidence, SRs identify research priorities, address questions that may not be answerable by individual studies, and identify gaps to be addressed in future primary research. There are several steps that need to be taken when developing SRs to provide the best available evidence—the most essential being the assessment of risk of bias (ROB). Several ROB tools have been developed for use according to study design. Increasingly used is the assessment of certainty of evidence using approaches such as those developed by the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) working group. Whereas ROB is assessed for individual studies, the certainty of evidence is assessed for each critical
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Expert Review Conducting a High-Quality Systematic Review 📖 https://t.co/8GjEkM2FUq #metaanalysis #riskofbias #systematicreviews https://t.co/tLsmA6qzHI
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Mashup Score: 6More Than Pain and Stiffness: Persistent Fatigue and Sleep Disturbance in Polymyalgia Rheumatica - 10 day(s) ago
Objective We aimed to examine fatigue and sleep disturbance in patients with recently diagnosed polymyalgia rheumatica (PMR) compared to age- and gender-matched controls, including associated characteristics and change over an 18-month follow-up period. Methods Patients meeting the 2012 European Alliance of Associations for Rheumatology/American College of Rheumatology classification criteria for PMR were prospectively recruited, together with matched controls. Assessments were undertaken 3 months after the commencement of glucocorticoids and again 18 months later. Fatigue was quantified using the Bristol Rheumatoid Arthritis Fatigue Multidimensional Questionnaire and the 36-item Short Form Health Survey vitality scale. Sleep was quantified using the Pittsburgh Sleep Quality Index. Other data collected included PMR disease activity, depression, anxiety, and physical function status. All participants underwent body composition by dual-energy x-ray absorptiometry and physical function te
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Research Article More Than Pain and Stiffness: Persistent Fatigue and Sleep Disturbance in Polymyalgia Rheumatica 📖 https://t.co/ZS2QQiFHe4 @Austin_Health #fatigue #sleep #polymyalgiarheumatica https://t.co/HioVlLpBjh
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Mashup Score: 3Uncommon Clinical and Radiological Presentation of Monosodium Urate Crystal Deposition in Parotid Glands - 27 day(s) ago
Monosodium urate (MSU) crystal deposition in the parotid glands is uncommon. A 66-year-old female individual with type 2 diabetes mellitus and stage 3-4 chronic renal disease (estimated glomerular filtration rate 30 mL/min/1.73 m2) presented with a 20-year history of asymptomatic bilateral parotid enlargement. Clinical examination revealed nontender bilateral parotid swelling. She had a history of chronic tophaceous gout and had been taking allopurinol 50 mg daily for 2 years. There was no history of alcohol or phenylbutazone use. A noncontrast computed tomography (CT) …
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Images in Rheumatology Uncommon Clinical and Radiological Presentation of Monosodium Urate Crystal Deposition in Parotid Glands 📖 https://t.co/MphtbP3Shu @NUHSofficial #monosodiumuratecrystals #parotidgland https://t.co/JRSB8SLDOf
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Research Article The Effect of Early Attainment of Minimal Disease Activity on Radiographic Outcomes: A Real-World Longitudinal Cohort Study in Psoriatic Arthritis 📖 https://t.co/zSFz4solvf @antrebea @ErasmusMC #diseaseactivity #psoriaticarthritis #radiographic https://t.co/xkKrpkJ6Ki