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Mashup Score: 0Antithrombin supplementation for prevention of vascular thrombosis after pediatric liver transplantation - 16 day(s) ago
After liver transplantation (LT), synthesis of coagulation factors by the graft recovers faster for pro thrombotic than anti thrombotic factors, resulting in a potential pro thrombotic imbalance. We studied the thrombotic and hemorrhagic complications in our pediatric LT series, providing supplementation of fresh frozen plasma (FFP) and/or antithrombin (AT) in the prophylactic antithrombotic regimen.
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Mashup Score: 0Storytelling for pediatric surgical education and beyond - 18 day(s) ago
Our group would like to share our experience with educational content creation for the pediatric surgical community. Approximately 7 years ago, the Stay Current in Pediatric Surgery podcast was created to disseminate pediatric surgical knowledge to a global audience with the intent to educate practitioners regarding latest updates and best practices for management of pediatric surgical conditions. More than the platform’s lifetime, its content has evolved as new strategies are trialed.
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Mashup Score: 0
Anorectal malformations (ARMs) are congenital anomalies in the newborn with an estimated incidence of 1 in 5000 live births [1,2]. ARMs are widely associated with other congenital anomalies with the rate between 20 and 70% [3]. These associations may be a part of VACTERL (vertebral anomalies, anorectal malformation, cardiovascular anomalies, trachea-esophageal fistula, renal and limb anomalies). VACTERL was originally described by Quan and Smith in 1973 as VATER and later in 1974 as VACTERL once the cardiac and limb associations were included by Temtamy and Miller [4].
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Mashup Score: 1Treatments and outcomes of intra-operative portal vein thrombosis in living-donor liver transplantation due to biliary atresia - 1 month(s) ago
Pediatric living-donor liver transplantation (LDLT) has become one of the most effective therapies for pediatric end-stage liver diseases. We aim to investigate the risk factors for intra-operative portal vein thrombosis (PVT) and the short- and long-term outcomes in children post LDLT.
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Mashup Score: 0
Advances in hepatoblastoma treatment have improved survival but have been accompanied by the chronic toxicities of pediatric cancer therapy. Cisplatin is the cornerstone of chemotherapy treatment for hepatoblastoma. The most frequent long-term complication of hepatoblastoma treatment is cisplatin-related ototoxicity. Among children who receive cisplatin, 25-90% will exhibit measurable hearing loss, impacting language and social development [1]. Therefore, efforts to identify children eligible for reduction or elimination of cisplatin-based chemotherapy while maintaining excellent oncologic outcomes are paramount in reducing the long-term toxicities of hepatoblastoma cancer treatment.
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Mashup Score: 3An enhanced recovery after surgery protocol in children who undergo nephrectomy for Wilms tumor safely shortens hospital stay - 2 month(s) ago
Wilms tumor is the most common malignant solid tumor that arises from the kidneys in children with approximately 500–600 new cases diagnosed yearly in the US. [1,2] Standard treatment includes chemotherapy and sometimes radiation therapy, but the cornerstone of treatment for unilateral tumors remains total nephrectomy and staging laparotomy with retroperitoneal lymph node sampling. While total nephrectomy is considered a major abdominal operation, it is often well tolerated within the pediatric Wilms tumor population and average length of stay continues to decrease, allowing for prompt oncologic follow-up and chemotherapy as recommended by the Children’s Oncology Group (COG) [3,4].
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Mashup Score: 0Children from disadvantaged neighborhoods experience disproportionate injury from interpersonal violence - 2 month(s) ago
Injury is the leading cause of death and disability among children in the United States (US) [1]. A major cause of pediatric injury is violence. The World Health Organization defines violence as “the intentional use of physical force or power, threatened or actual, against oneself, another person, or against a group or community, that either results in or has a high likelihood of resulting in injury, death, psychological harm, maldevelopment or deprivation” [2]. Interpersonal violence is one type of violence, defined as the intentional use of physical force against others by another individual or small group, which results in considerable morbidity and mortality [3].
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Mashup Score: 12Sildenafil attenuates intestinal injury in necrotizing enterocolitis independently of endothelial nitric oxide synthase - 2 month(s) ago
Necrotizing enterocolitis (NEC) is a devasting intra-abdominal disease that occurs primarily in preterm neonates. Clinically, NEC presents as feeding intolerance, abdominal distention, and bloody stools, which can quickly progress to sepsis and intestinal perforation [1]. Mortality from NEC remains high and accounts for 10–21% of all deaths in premature babies [2]. Multiple factors have been shown to play a role in its development, including prematurity, formula feeds, and intestinal dysbiosis [3,4].
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Mashup Score: 13Modified technique for robot-assisted laparoscopic infantile ureteral reimplantation for obstructive megaureter - 2 month(s) ago
To describe a novel modification of technique to improve efficacy of robot-assisted laparoscopic extravesical ureteral reimplantation (RALUR-EV) in infants.
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Mashup Score: 0
Ronald Wilbur Cooke was born in Newport, RI, in 1919. His family moved to Windsor, CT, where he spent most of his childhood. After completing secondary school, he attended Yale University earning a Bachelor of Science degree in 1940 and a medical degree in 1943. An early interest in caring for children first led him to a pediatric residency at Strong Memorial Hospital in Rochester, NY (Fig. 1).
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ANTITHROMBIN SUPPLEMENTATION FOR PREVENTION OF VASCULAR THROMBOSIS AFTER PEDIATRIC LIVER TRANSPLANTATION https://t.co/H5EjDSHAuH #SoMe4PedSurg #jpedsurg