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    • Mashup Score: 17
      Chemokine CCL19 promotes type 2 T cell differentiation and allergic airway inflammation - 1 year(s) ago

      Allergic asthma is driven largely by allergen-specific type 2 T helper (Th2) cells, which develop in regional lymph nodes upon the interaction of naïv…

      Source: www.sciencedirect.com
      Categories: General Medicine News, Allergy-Immunology
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        CCR7 and its chemokine ligand CCL21 are known to play a key role in allergic airway disease. Learn about a novel TH2 cell-inducing function of CCL19. Strategies to block the pathway may help to reduce disease incidence or severity. https://t.co/rtglL2tTAs

    • Mashup Score: 10
      Remibrutinib demonstrates favorable safety profile and sustained efficacy in chronic spontaneous urticaria over 52 weeks - 1 year(s) ago

      Remibrutinib (LOU064), an oral, highly selective Bruton tyrosine kinase inhibitor, offers fast disease control in patients with chronic spontaneous ur…

      Source: www.sciencedirect.com
      Categories: General Medicine News, Allergy-Immunology
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        Remibrutinib may offer a new oral treatment option for patients with chronic spontaneous urticaria inadequately controlled by H1 antihistamines. Editors’ Choice findings demonstrate favorable safety and sustained efficacy over 52 weeks of treatment. https://t.co/zugkOfa5Qa

    • Mashup Score: 24
      IgE to common food allergens is associated with cardiovascular mortality in the National Health and Examination Survey and the Multi-Ethnic Study of Atherosclerosis - 1 year(s) ago

      In individuals without symptomatic food allergy, food-specific IgE is considered clinically irrelevant. However, recent studies have suggested that ga…

      Source: www.sciencedirect.com
      Categories: General Medicine News, Allergy-Immunology
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        In people without symptomatic food allergy, the presence of food-specific IgE is considered clinically irrelevant. An Editors’ Choice paper reports data that may challenge this assumption. Read on. https://t.co/u5eOWtKjbt

    • Mashup Score: 10
      Revised Swedish infant feeding guidelines are associated with earlier introduction of allergenic foods - 1 year(s) ago

      Randomized controlled trials have demonstrated that early introduction of allergenic foods, such as peanut and egg, can reduce food allergy in high-ri…

      Source: www.sciencedirect.com
      Categories: General Medicine News, Allergy-Immunology
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        Early introduction of allergenic foods can reduce allergy development. Have the Swedish National Food Agency’s revised infant feeding guidelines affected food introduction and early manifestations of disease? Here’s an Editors’ Choice report. https://t.co/btWniPpu8f

    • Mashup Score: 14
      IgE directly affects eosinophil migration in chronic rhinosinusitis with nasal polyps through CCR3 and predicts the efficacy of omalizumab - 1 year(s) ago

      Whether IgE affects eosinophil migration in chronic rhinosinusitis with nasal polyps (CRSwNP) remains largely unclear. Moreover, our understanding of …

      Source: www.sciencedirect.com
      Categories: General Medicine News, Allergy-Immunology
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        The role of IgE in chronic rhinosinusitis with nasal polyps is undergoing reassessment with new observations from anti-IgE therapy. An Editors’ Choice paper reports that baseline local IgE+cell counts are predictive of omalizumab treatment efficacy. https://t.co/wku8cgFUTm

    • Mashup Score: 3
      Asthma morbidity measures across Black ethnic subgroups - 1 year(s) ago

      Black adults are disproportionately affected by asthma and are often considered a homogeneous group in research studies despite cultural and ancestral…

      Source: www.sciencedirect.com
      Categories: General Medicine News, Allergy-Immunology
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        Black adults are often considered a homogenous group in asthma research studies despite cultural and ancestral differences. Does asthma morbidity differ across adults in Black ethic subgroups? Read an Editors’ Choice report. https://t.co/ntHKhrh0p3

    • Mashup Score: 2
      Untargeted metabolomic profiling in children identifies novel pathways in asthma and atopy - 1 year(s) ago

      Asthma and other atopic disorders can present with varying clinical phenotypes marked by differential metabolomic manifestations and enriched biologic…

      Source: www.sciencedirect.com
      Categories: General Medicine News, Allergy-Immunology
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        Metabolomics is the study of the small molecule metabolic products that are produced in living systems. New data detail a metabolomic profile of children with atopic asthma, suggesting underlying mechanisms of disease. Read the Editors’ Choice findings. https://t.co/2eeQ0TCExy

    • Mashup Score: 6
      Airway wall extracellular matrix changes induced by bronchial thermoplasty in severe asthma - 1 year(s) ago

      Airway remodeling is a prominent feature of asthma, which involves increased airway smooth muscle mass and altered extracellular matrix composition. B…

      Source: www.sciencedirect.com
      Categories: General Medicine News, Allergy-Immunology
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        Bronchial thermoplasty is a treatment for severe asthma that targets airway remodeling, and data suggest it improves patients’ quality of life and clinical outcomes. How do these findings relate to changes in the airway wall? Learn more. https://t.co/4vbio3KZV5

    • Mashup Score: 0
      Human PLCG2 haploinsufficiency results in a novel NK cell immunodeficiency - 1 year(s) ago

      Author links open overlay panel Antonio Condino-Neto MD, PhD Disclosure of potential conflict of interest: The author declares no relevant conflicts of interest. There are more references available in the full text version of this

      Source: www.sciencedirect.com
      Categories: General Medicine News, Allergy-Immunology
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        Some people experience severe and/or recurrent herpesvirus infections, and a subset of them has defects in natural killer cells. Data from a study that appeared in last month’s issue suggested the genetic cause. Here’s an editorial on the findings. https://t.co/wJWuyp6PSg

    • Mashup Score: 10
      Dupilumab in type 2 airway inflammation—a step forward in targeted therapy for COPD - 1 year(s) ago

      Author links open overlay panel Ronnie Voon Shiong Tan MBBS, MRCP, Hnin Wint Wint Aung MBBS, MRCP, Cara Flynn MBChB, MRCP, Neil J. Greening BMedSci (Hons), MBBS, PhD, MRCP, Christopher E. Brightling BSc (Hons), MBBS, FRCP, PhD, FMedSci Supported by the National Institute for Health and Care Research (NIHR), Leicester Biomedical Research Centre. The views expressed are those of the author(s) and not necessarily those of the NIHR or the Department of Health and Social Care. Disclosure of potential conflict

      Source: www.sciencedirect.com
      Categories: General Medicine News, Allergy-Immunology
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        Eosinophilic chronic obstructive pulmonary disease (COPD) is found in a sizable subgroup of patients and could be a treatable trait. An editorial discusses encouraging data from the New England Journal of Medicine on targeting type 2 inflammation in COPD. https://t.co/xsdZ3ZyEOt

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    Journal of Allergy and Clinical Immunology

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    The Journal of Allergy and Clinical Immunology is an official publication of the American Academy of Allergy, Asthma, and Immunology.

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