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Mashup Score: 44In vivo antibody labeling route and fluorophore dictate labeling efficiency, sensitivity, and longevity - 2 month(s) ago
Abstract. Leukocytes migrate through the blood and extravasate into organs to surveil the host for infection or cancer. Recently, we demonstrated that intr
Source: academic.oup.comCategories: General Medicine NewsTweet
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Mashup Score: 28
Abstract. B cell depletion is an efficacious therapy for multiple sclerosis, but its long-term safety profile in the gastrointestinal tract has not been sp
Source: academic.oup.comCategories: General Medicine NewsTweet-
#ICYMI: B cell depletion is a successful treatment for multiple sclerosis, but its long-term safety profile in the gut was unknown. A new study demonstrated that prolonged B cell depletion did not significantly impact IgA levels or gut health. Learn more: https://t.co/Zb6qk3OURP https://t.co/rsnIoiQPGU
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Mashup Score: 4
Abstract. Macrophage differentiation, phenotype, and function have been assessed extensively in vitro by predominantly deriving human macrophages from peri
Source: academic.oup.comCategories: General Medicine NewsTweet-
On the April cover, researchers evaluated the phenotype and function of human macrophages from bone marrow vs. peripheral blood to show that isolating cells from different sources does not affect macrophage differentiation after CD14 isolation. 🔗 https://t.co/KMr67lFb3R. https://t.co/dcuWEtCYfx
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Mashup Score: 3CD209d/e are required for macrophage-mediated phagocytosis and activation during methicillin-resistant Staphylococcus aureus pulmonary host defense - 2 month(s) ago
Abstract. Staphylococcus aureus is a commensal and opportunist pathogen of the upper respiratory tract. The recognition of pathogen-associated molecular pa
Source: academic.oup.comCategories: General Medicine NewsTweet-
Methicillin-resistant S. aureus (#MRSA) causes difficult-to-treat infections in humans. #ICYMI: Data suggest that CD209d/e are essential receptors to control inflammation by activating macrophages leading to MRSA uptake and killing. Learn more: https://t.co/CqtecqhIU9. https://t.co/NOEa4Kd28M
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Mashup Score: 2Cellular immune changes during severe antisense oligonucleotide-associated thrombocytopenia in a nonhuman primate model - 2 month(s) ago
Abstract. Antisense oligonucleotides (ASOs) are a new class of single-stranded DNA–based drugs that hold great therapeutic potential. A low incidence of se
Source: academic.oup.comCategories: General Medicine NewsTweet-
Antisense oligonucleotides are single-stranded DNA–based drugs that hold great therapeutic potential, but a low incidence of severe, dose-dependent, and reversible thrombocytopenia has been reported in some nonhuman primates. New research uncovers why: https://t.co/F2DwS8qlZY. https://t.co/Qer9UXjMpj
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Mashup Score: 17Discovery of a new anti-γc antibody in clinical development for the treatment of autoimmune diseases - 2 month(s) ago
Abstract. Autoimmune disease refers to a condition when the immune system anomalously attacks its own body and healthy cells. Although the exact causes of
Source: academic.oup.comCategories: General Medicine NewsTweet-
Anti-gamma-c antibody hC2 may offer a more efficacious therapy compared to antibodies targeting a single gamma-c cytokine and a safer alternative to JAK inhibitors, potentially fulfilling the unmet medical needs of autoimmune diseases in the future. 🔗 https://t.co/jTJJ5r5ZrC. https://t.co/usGyno5GK9
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Mashup Score: 29The transcription factor RORα is required for the development of type 1 innate lymphoid cells in adult bone marrow - 2 month(s) ago
Abstract. Type 1 innate lymphoid cells (ILC1s) respond to infections and tumors by producing IFN-γ. Although RAR-related orphan receptor α (RORα) is requir
Source: academic.oup.comCategories: General Medicine NewsTweet-
A new Cutting Edge paperstudy demonstrates that ROR-alpha promotes type 1 innate lymphoid cell (ILC1) differentiation while suppressing NK cell differentiation at the ILC precursor stage in adult bone marrow. Learn more: https://t.co/yee8yxFU3I. https://t.co/yc9N3vrYhP
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Mashup Score: 0DHODH inhibition alters T cell metabolism limiting acute graft-versus-host disease while retaining graft-versus-leukemia response - 2 month(s) ago
The Editors have selected this article as a highlight of the issue.
Source: academic.oup.comCategories: General Medicine NewsTweet-
In this April #TopRead @ParvathiRangan2 at @OSUHematology identified dehydrogenase inhibition as an innovative treatment strategy in allo-HCT recipients to reduce graft-vs-host-disease severity while retaining graft-vs-leukemia response. Learn more: https://t.co/omZ2g3abSs. https://t.co/wf9Yyzbk52
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Mashup Score: 4Combination Therapy Blocking TNF Superfamily Members 14 and 15 Reverses Pulmonary Fibrosis - 2 month(s) ago
Abstract. Currently, anti-inflammatory drugs fail to reduce pulmonary fibrosis in the clinic and there is an urgent unmet need to develop novel anti-fibrot
Source: academic.oup.comCategories: General Medicine NewsTweet-
Today’s #Top Read is on #PulmonaryFibrosis (PF) from @herro86957 at @CincyResearch. This study identified two novel mediators of PF, LIGHT and TL1A, and demonstrated that targeting both can reverse scarring. Learn more: https://t.co/fFroQ8pWs6. https://t.co/KFOC0jzKcL
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Mashup Score: 9Exploring the genetic mechanisms driving KIR diversification - 2 month(s) ago
The Editors have selected this article as a highlight of the issue.
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A #TopRead article from Dr. Jesse Bruijnesteijn found that a diverse repertoire of killer cell immunoglobulin-like receptors (KIRs) contributes to the protection of individuals and populations against pathogen evasion and subversion. Read it in The JI: https://t.co/uO3IkyZQYq https://t.co/3EkPiQgUZW
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A novel method demonstrated how different injection routes and fluorophores affect the labeling of leukocytes with anti-CD45.2 antibody, highlighting the utility of this approach for defining leukocyte migration in the context of homeostasis and cancer: https://t.co/HdFpder0Gq. https://t.co/hK2xZBl32a