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Mashup Score: 14Accurate enumeration of pathogen-specific and virtual memory CD8 T cells after infection - 23 day(s) ago
Abstract. Establishing the magnitude and kinetics of polyclonal Ag-specific CD8 T-cell responses, in addition to their functional fitness, is critical for
Source: academic.oup.comCategories: General Medicine NewsTweet
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Mashup Score: 7Impact of CD4+ T cell and TCR repertoires on SARS-CoV-2-Specific antibody responses in PLWH following COVID-19 vaccination - 24 day(s) ago
Abstract. In people living with human immunodeficiency virus (HIV, PLWH), the coronavirus disease 2019 (COVID-19) vaccine often results in a limited humora
Source: academic.oup.comCategories: General Medicine NewsTweet-
New #clinical data found that the differential SARS-CoV-2 antibody response in people living with #HIV was not solely determined by CD4+ T cell count but also influenced by the progression of immune reconstitution and the TCR profile. Read more: https://t.co/p3tEyulZeB https://t.co/22jS5xdh4h
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Mashup Score: 2Decoding autoimmunity: HLA-DQβ and type 1 diabetes - 25 day(s) ago
This Pillars of Immunology article features the seminal 1987 Nature paper by J.A. Todd, J.I. Bell, and H.O. McDevitt, titled “HLA-DQβ gene contributes to s
Source: academic.oup.comCategories: General Medicine NewsTweet-
May’s Pillars of Immunology article highlights the seminal 1987 Nature paper by J.A. Todd, J.I. Bell, and H.O. McDevitt, which provided a breakthrough in understanding genetic susceptibility to type 1 #diabetes. Read the full commentary in The JI: https://t.co/Oum9MWO9Ge. https://t.co/2al1cKBiKz
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Mashup Score: 100
Abstract. Long-lasting immunological memory is a core feature of the adaptive immune system that allows an organism to have a potent recall response to for
Source: academic.oup.comCategories: General Medicine NewsTweet-
For the #aging special collection, Dr. William Foster et al. report that germinal centers from aged mice and aged humans are smaller after immunization and harbor altered B cell repertoires. Learn more: https://t.co/9VaBdURvpL https://t.co/1PqxKl170Q
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Mashup Score: 29
Abstract. Functional alterations with age are observed in all human systems, but the aging of the adaptive immune system displays both general changes affe
Source: academic.oup.comCategories: General Medicine NewsTweet-
In the #aging collection, Dr. Nianbin Song et al. provide a unique perspective by contrasting universal features of T cell aging in humans with changes that are specific to an individual. Read more: https://t.co/sf6Jt7W8E1 https://t.co/rkVAfCNTQ8
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Mashup Score: 24Aging and neurodegeneration: when systemic dysregulations affect brain macrophage heterogeneity - 28 day(s) ago
Abstract. Microglia, the major population of brain resident macrophages, differentiate from yolk sac progenitors in the embryo and play multiple nonimmune
Source: academic.oup.comCategories: General Medicine NewsTweet-
Dr. Paul Joly et al. provide a timely review in the #aging special collection that discusses how various factors affect macrophage heterogeneity throughout the lifespan. Learn more: https://t.co/w2YFIOgzl7 https://t.co/I0hHJQbgEv
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Mashup Score: 12Immunological biomarkers of aging - 29 day(s) ago
Abstract. The immune system has long been recognized for its critical role in the elimination of pathogens and the development of autoimmune diseases, but
Source: academic.oup.comCategories: General Medicine NewsTweet-
A review in the #aging special collection by Dr. Fei Wu et al used changes in proinflammatory cytokines to develop an inflammatory clock called iAge. These biomarkers can be used to track disease and discover successful interventions. Read more: https://t.co/t69howL20G https://t.co/12aiZDcgUv
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Mashup Score: 15Aging’s impact on the immune system - 1 month(s) ago
An onslaught of infectious disease events over the last 5 yr has focused international attention on immune aging. Specifically, how does the immune system
Source: academic.oup.comCategories: General Medicine NewsTweet-
A special collection on #aging and the immune system highlights the expanding field of immune aging, featuring an invited commentary from a pioneer in the field and a collection of 5 brief reviews from leaders in aging research. Read the editorial: https://t.co/eJzrfhueFP. https://t.co/nbOzWGee44
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Mashup Score: 15
Abstract. The capacity of Mycobacterium tuberculosis (Mtb) to establish long-term survival is attributed to its ability to subvert host defense mechanisms,
Source: academic.oup.comCategories: General Medicine NewsTweet-
Mycobacterium #tuberculosis (Mtb) lipids are believed to play a role in Mtb subverting host defenses, but how is unknown. New data found an intricate mechanism of Mtb-driven macrophage immunomodulation that may favor its long-term survival. Learn more: https://t.co/3T0jurmQL4. https://t.co/ueFQpBXW7v
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Mashup Score: 22EZH2 coordinates memory B-cell programming and recall responses - 1 month(s) ago
Abstract. Antigen-experienced memory B-cells (MBC) are endowed with enhanced functional properties compared to naïve B cells and play an important role in
Source: academic.oup.comCategories: General Medicine NewsTweet-
#ICYMI: Data showed EZH2 is a critical epigenetic modulator of antigen-experienced memory B-cells differentiation and functional potential during reactivation. Find it in The JI: https://t.co/Oc9Ui9DDa3 https://t.co/XhzNa9LTbo
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Data shows that defining the magnitude and kinetics of an Ag-specific CD8 T-cell response requires distinguishing pathogen-induced effector and memory CD8 T cells from Tvm cells to improve the resolution of studies understanding CD8 T cells. Read more: https://t.co/V2EbMJKhem. https://t.co/AC9m3NgLU0