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Mashup Score: 2Vessel-sparing Radiotherapy for Localized Prostate Cancer to Preserve Erectile Function: A Single-arm Phase 2 Trial - PubMed - 12 day(s) ago
In this interim analysis we looked at using a novel approach to spare critical erectile structures to preserve erectile function after prostate cancer radiotherapy. We found that almost 90% of patients at 5 yr after treatment remained sexually active, significantly higher than previous studies with …
Source: pubmed.ncbi.nlm.nih.govCategories: General Medicine NewsTweet
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Mashup Score: 144The pivot penalty in research - 21 day(s) ago
Nature – An analysis of millions of scientific papers and patents reveals a ‘pivot penalty’ when researchers shift direction, with the impact of studies decreasing rapidly the further…
Source: www.nature.comCategories: General Medicine NewsTweet-
RT @yian_yin: 🚨New paper🚨 Excited to share our latest on @Nature today: The PIVOT PENALTY in research. https://t.co/V4ENiGCssY More than f…
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Mashup Score: 3
We have previously reported that radiotherapy (RT) added to androgen-deprivation therapy (ADT) improves survival in men with locally advanced prostate cancer. Here, we report the prespecified final analysis of this randomized trial. NCIC Clinical …
Source: pmc.ncbi.nlm.nih.govCategories: General Medicine NewsTweet-
@JoeBiden @SocialSecurity @theNCI @CNN @lkayat @jeshoag @MUSICUrology @jimhumd @TylerSbrt 11/x However, if diagnosed with high-risk disease, there are multiple RCTs showing that there is a survival benefit within the first 4 years when giving radiotherapy vs just androgen deprivation therapy. https://t.co/2Na8Ra3sFV https://t.co/fRIfJGP6lc
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Mashup Score: 6Cost-effectiveness of Prostate Cancer Screening Using Magnetic Resonance Imaging or Standard Biopsy Based on the STHLM3-MRI Study - 26 day(s) ago
Within a prostate cancer screening context, is magnetic resonance imaging (MRI)-based screening more cost-effective than no screening and screening using prostate-specific antigen (PSA) alone? In this economic evaluation study of 1532 adult men in …
Source: pmc.ncbi.nlm.nih.govCategories: General Medicine NewsTweet-
@JoeBiden @SocialSecurity @theNCI @CNN 7/x MRI also valuable for further risk stratification to reduce unnecessary biopsies. A trial-based model in Sweden showed that an MRI-first screening strategy cut the number of lifetime biopsies and overdiagnosed cases by ~50% https://t.co/Oq8MGP6tfp @lkayat @jeshoag
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Mashup Score: 3Development and validation of a life expectancy calculator for US patients with prostate cancer - 26 day(s) ago
To develop and validate an accurate, usable prediction model for other‐cause mortality (OCM) in patients with prostate cancer diagnosed in the United States. Model training was performed using the National Health and Nutrition Examination Survey …
Source: pmc.ncbi.nlm.nih.govCategories: General Medicine News, UrologyTweet-
2/x So let us take @JoeBiden case and look at 72yo white man, who is married, has college degree, with a normal BMI without known comorbidities at 72yo. His probability of dying of something other than PCa 15 years later (87yo) is only 41% https://t.co/f1uYWZD73b https://t.co/2ORQbPeDgu
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Mashup Score: 36Clinical-genomic Characterization Unveils More Aggressive Disease Features in Elderly Prostate Cancer Patients with Low-grade Disease - 27 day(s) ago
Using genomic classifier scores, older men with low-risk prostate cancer were shown to harbor more aggressive disease than younger patients. This suggests that elderly patients with presumed-indolent disease may harbor a more aggressive phenotype, possibly requiring more active treatment.
Source: www.eu-focus.europeanurology.comCategories: General Medicine News, UrologyTweet-
@AmericanCancer @dr_coops @jeshoag @VickersBiostats @AmerUrological @ASCO @ASTRO_org @PCF_Science @wandering_gu @EdwardSchaeffer @NRGonc 9/x Gene expression profiles of men >75 yo w/ low grade PCa exhibit more aggressive genomic features than younger men https://t.co/YW751SdVYZ @Veracyte @Davicioni https://t.co/dfBLXVlzev
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Mashup Score: 3210-Year Outcomes after Monitoring, Surgery, or Radiotherapy for Localized Prostate Cancer | NEJM - 27 day(s) ago
The comparative effectiveness of treatments for prostate cancer that is detected by prostate-specific antigen (PSA) testing remains uncertain. We compared active monitoring, radical prostatectomy, …
Source: www.nejm.orgCategories: General Medicine News, UrologyTweet-
@AmericanCancer @dr_coops @jeshoag @VickersBiostats @AmerUrological @ASCO @ASTRO_org @PCF_Science @wandering_gu @EdwardSchaeffer 7/x Older men more likely to die of non-PCa causes, such as heart dz. However, older men more likely to be diagnosed with PCa and more likely to die of PCa. https://t.co/OiR1zK382t In ProtecT trial nearly all the deaths from PCa in men not receiving immediate tx occurred in men https://t.co/ReRk0rf8ck
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Mashup Score: 31USPSTF Recommendation: Screening for Prostate Cancer - 27 day(s) ago
This 2018 updated Recommendation Statement from the US Preventive Services Task Force concludes that clinicians should not screen for prostate cancer in men aged 55 to 69 years who do not express a preference for screening (C recommendation) and recommends against PSA-based screening in men 70 years…
Source: jamanetwork.comCategories: General Medicine News, UrologyTweet-
@AmericanCancer @dr_coops @jeshoag @VickersBiostats @AmerUrological @ASCO @ASTRO_org @PCF_Science @wandering_gu @EdwardSchaeffer 6/x The current 2018 U.S Preventive Service Task Force (USPSTF) recommends against PSA screening in men >70 yo. https://t.co/RtyQ5r2Uhn Again, many PCa focused academic/scientific societies disagree with USPSTF. https://t.co/9OkM6pIQfI
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Mashup Score: 3An evidence based approach to COVID vaccination - 28 day(s) ago
For Closed Captions:https://secure-web.cisco.com/1BXytnVDBbBM1fwxOYzMlCpjIdmaJhFVP-euR-j7Xs1BukyX1HBvZczvgu2cvcAsfv93jHU0MoqYCuGmsvpyCiEIWach3ZVzhU9k8N107L-2…
Source: www.youtube.comCategories: General Medicine NewsTweet-
Ppl have their strong opinions, and we should all hope that new leadership in the @US_FDA makes progress for America and our patients. I enjoyed this presentation and found it very balanced, more than anticipated. https://t.co/2vB431iZIW Lots of misinformation out there to what
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Mashup Score: 18FOCAL THERAPY Defining Candidates for Partial Gland Prostate Ablation: A Critical Challenge for Focal Therapy - American Urological Association - 1 year(s) ago
Improvement in prostate cancer (PCa) localization through multiparametric MRI (mpMRI) coupled with targeted biopsy has spurred interest in applying similar principles to address magnetic resonance (MR)-visible lesions via partial gland ablation. Although ongoing work from the centers of excellence provides encouraging short- and intermediate-term oncological outcomes for partial gland ablation strategies, clear recommendations on the ideal selection criteria for focal therapy (FT) remain undefined.
Source: auanews.netCategories: General Medicine News, Hem/OncsTweet-
AUA giving strong platform for all of this without a single RCT showing benefit: https://t.co/ExbW5iXlRW https://t.co/LDzUgpsUhp
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@dr_coops @jimhumd @TylerSbrt @urogeek @UCSFUrology @MUSICUrology Single arm phase 2. https://t.co/Iw9OyDq9pP RCT completed and awaiting 2 year followup. Very early data reported by @ndesai2005 with promising early signal!