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Mashup Score: 26Honoring Her ‘Angel’ - University of Miami Medicine Magazine - 11 month(s) ago
After an attempted surgery at a South Florida community hospital, doctors diagnosed Kathleen Garafola with locally advanced, unresectable pancreatic cancer.
Source: magazine.med.miami.eduCategories: General Medicine News, Hem/OncsTweet
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Mashup Score: 22
Sylvester researchers are testing a new treatment approach for a subset of patients with pancreatic cancer.
Source: news.med.miami.eduCategories: General Medicine News, Hem/OncsTweet-
💪🏽🙏🏽🫶🏽. CC: @PeterHoseinMD Appreciate the support from @TheVFoundation @MiamiDolphins @TackleCancer @SylvesterCancer @DrSDNimer Read the story here: https://t.co/scbApGA2bf https://t.co/LVVVAQYMXH
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Mashup Score: 3
Pancreatic ductal adenocarcinoma (PDAC) is characterized by intratumoral abundance of neutrophilic/polymorphonuclear myeloid-derived suppressor cells (PMN-MDSC) which inhibit T-cell function through JAK2/STAT3-regulated arginase activity. To overcome limitations of systemic inhibition of PMN-MDSCs in cancer-bearing patients—i.e., neutropenia and compensatory myelopoietic adaptations—we develop a nanoengineering strategy to target cell-specific signaling exclusively in PMN-MDSCs without provoking neutropenia. We conjugate a chemically modified small-molecule inhibitor of MDSC-surface receptor CXCR2 (AZD5069) with polyethylene glycol (PEG) and chemically graft AZD5069-PEG constructs onto amphiphilic polysaccharide derivatives to engineer CXCR2-homing nanoparticles (CXCR2-NP). Cy5.5 dye-loaded CXCR2-NP showed near-exclusive uptake in PMN-MDSCs compared with PDAC tumor-cells, cancer-associated fibroblasts, and macrophages. Encapsulation of JAK2/STAT3i Ruxolitinib (CXCR2-NPRuxo) resulted in
Source: www.biorxiv.orgCategories: General Medicine News, Oncologists1Tweet-
Here is the link to this @DeptofDefense @CDMRP funded work: https://t.co/xazdpAghPf. 💪🏽💪🏽work by @iamnilesh1 driving this project & huge thx to @DharShanta for her expert guidance & collaboration
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Mashup Score: 13
Annals of Surgical Oncology – Data regarding the survival impact of converting frozen-section (FS):R1 pancreatic neck margins to permanent section (PS):R0 by additional resection (i.e.,…
Source: link.springer.comCategories: General Medicine News, Hem/OncsTweet-
Agreed! We published data with similar conclusions from the #CentralPancreasConsortium 7-center dataset a couple yrs ago @AnnSurgOncol👉🏽https://t.co/6N62mz3xET @SylvesterCancer @FrancisIgorMac1 @NbmerchantMD @SyedAAhmad5 @skmaithel @DavidKoobyMD @GregWilson152 @kimhjUNC et al https://t.co/EgZpu5GP3O
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Mashup Score: 6Adjuvant Chemotherapy in Patients With Resected Pancreatic Cancer After Neoadjuvant FOLFIRINOX - 1 year(s) ago
This cohort study uses data from an existing cohort of patients undergoing resection of pancreatic cancer to assess the overall survival of patients treated with neoadjuvant FOLFIRINOX after surgery for pancreatic ductal adenocarcinoma.
Source: jamanetwork.comCategories: General Medicine News, Hem/OncsTweet-
Nice work from @tdonahuemd & multi-institutional team! Towards a more nuanced & biologically driven selection of adj chemo in pts rec’v neoadj tx➕🔪. Must invoke Dutch study @MarcBesselink @EAHPBA et al👉🏽https://t.co/XHIeO9rLnG. 👁️ out for our #CPC study examining this❓soon… https://t.co/sg3EIr3Vr2
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Mashup Score: 15Improving patient stratification and selection for curative-intent treatment in localized pancreatic cancer - 1 year(s) ago
Improving patient stratification and selection for curative-intent treatment in localized pancreatic cancer
Source: hbsn.amegroups.orgCategories: General Medicine News, Hem/OncsTweet-
Well done 👏🏽 @MarysiaMartos @theNCI #T32 fellow @SylvesterCancer @UMJMHSurgery on leading this invited commentary on patient stratification& selection for curative-intent treatment in localized #PancreaticCancer in @HepatobiliaryN @The_AMEGroup https://t.co/9794YMmFX8
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Mashup Score: 4
Co-occurrent KRAS and TP53 mutations define a majority of patients with pancreatic ductal adenocarcinoma (PDAC) and define its pro-metastatic proclivity. Here, we demonstrate that KRAS-TP53 co-alteration is associated with worse survival compared with either KRAS-alone or TP53-alone altered PDAC in 245 patients with metastatic disease treated at a tertiary referral cancer center, and validate…
Source: www.nature.comCategories: General Medicine News, Hem/OncsTweet-
This👇🏽! And why it’s important to 🧐 distinct transcriptional networks invoked by cooperativity w KRAS etc in driving immune suppression (shameless 🔌: https://t.co/1YaXh2Ahjg) & metastatic proclivity (https://t.co/Kp8OOnulxa)! IMO must account for this in era of KRAS inhibitors https://t.co/WvitWUsmdf
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Mashup Score: 8
Single-nucleus and spatial, whole-transcriptome profiling of 43 pancreatic adenocarcinomas provides a refined molecular and cellular classification, highlighting a new neoadjuvant treatment-associated neural-like progenitor tumor cell state.
Source: www.nature.comCategories: General Medicine News, Hem/OncsTweet-
@Aiims1742 @HenryFordHealth @HCCvPDAC @Daniel_Salas671 @NinaSteele17 @DelgiornoKathy @SearsRosie Interesting! Excited to read in depth. Congrats @Daniel_Salas671 @HCCvPDAC & HFPCC team! CC: @DrWilliamHwang & his recent @NatureGenet paper re role of NRP cell persistence following chemoRT https://t.co/Asydh5hEhr
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Mashup Score: 53Student Spotlight: Riyaan Datta '30 - Gulliver Prep - 1 year(s) ago
Riyaan Datta ‘30 is the reigning Florida State Elementary (K-5) Chess Champion.
Source: www.gulliverprep.orgCategories: General Medicine News, Hem/OncsTweet-
So proud of our 12yo #RiyaanDatta who was featured in @GulliverPrep_ Student Spotlight. He is an accomplished♟️chess🌟 & model 👨🎓,but we’re most proud that he is humble, kind & made of the “right stuff.” Pls take a min to read👇🏽 #SurgParenting @SChoukkar https://t.co/EBG3XReJw4
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Mashup Score: 7Help me Challenge Cancer! - 1 year(s) ago
The DCC is a year-round collective community movement to raise money in support of Sylvester Comprehensive Cancer Center at the University of Miami. With your support, we are saving more lives. #OneTeamOneFight
Source: dolphins.donordrive.comCategories: General Medicine News, Hem/OncsTweet-
Can’t wait for one of my favorite events of the year #DCC24 @TackleCancer @MiamiDolphins @SylvesterCancer! I’m riding 54 miles 🚴 to raise life-saving 💵 for 🦀 research 🔬🧬🧪! Will you pledge a donation towards my fundraising goal?? https://t.co/8LCvIEd5gd
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The bravery of our pts never ceases to amaze me. This enduring gift to our mission of eradicating #PancreaticCancer will remain a timeless testament to Kathy’s unflinching strength, & a💉in💪🏽 for our prgm @SylvesterCancer: https://t.co/RDe4K4SXwh CC: @noah_youngstrom @BrittenKing