• Mashup Score: 5

    Won et al. demonstrate that PD-1 inhibitor treatment alone induces myocarditis in A/J mice, creating a mouse model for immune-checkpoint-inhibitor-associated myocarditis. Cardiac myosin-specific autoreactive T cells drive the pathogenesis of PD-1 inhibitor-induced myocarditis in mice. PD-1-expressing cardiac myosin-specific T cells are present in the heart during naive conditions.

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  • Mashup Score: 2

    SignificanceCenturies-old observations of ‘misplaced’ cells in the thymic medulla have recently been unified in the description of mimetic cells, specialized thymic epithelial cells that appropriate the lineage-defining transcription factors of diverse cell types to express peripheral-tissue antigens within the thymus and tolerize maturing T cells. Defects in mimetic cells may play major roles in…

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