• Mashup Score: 0

    BACKGROUND: One-time atrial fibrillation (AF) screening trials in older adults have produced mixed results. In a secondary analysis of the VITAL-AF trial, we aimed to identify a subset of people in whom such screening is effective, using effect-based and risk-based approaches. METHODS: The VITAL-AF trial was a cluster-randomized trial of 1-time, 30-second single-lead ECG screening during primary care visits. It enrolled adults aged ≥65 years in 16 Massachusetts General Hospital primary care practices (2018–2019). In this secondary analysis, we tested 2 approaches to identify subgroups where screening is effective. First, we developed an effect-based model using the T-learner, a causal inference approach that estimates screening effects by separately training 2 predictive models—one for screening and one for usual care—and then compares their predictions for each individual. Second, we used a validated AF risk model (Cohorts for Heart and Aging Research in Genomic Epidemiology AF) to te

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    • Identifying a Heterogeneous Effect of Atrial Fibrillation Screening in Older Adults: A Secondary Analysis of the VITAL-AF Trial @steven_lubitz @patrick_ellinor @JeffAshburner @jaymiyer @sachinjshah #AHAJournals https://t.co/fASWGUjNV1 https://t.co/CsXfYNZDSF

  • Mashup Score: 0

    BACKGROUND: As cardiovascular disease (CVD) is the leading cause of noncancer mortality in colorectal or gastric cancer patients, it is essential to identify patients at increased CVD risk. Coronary artery calcium (CAC) is an established predictor of atherosclerotic CVD; however, its application is limited in this population. This study evaluates the association between automated CAC scoring using chest computed tomography and atherosclerotic CVD risk in colorectal or gastric cancer patients. METHODS: A retrospective cohort study was conducted using electronic health records linked to claims data of colorectal or gastric cancer patients who underwent non-ECG-gated chest computed tomography at 2 tertiary hospitals in South Korea between 2011 and 2019. CAC was automatically quantified using deep learning software and used to classify patients into 4 groups (CAC=0, 0400). The primary outcome was major adverse cardiovascular events (myocardial infarction, stroke, or cardiovascular mortalit

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    • Hidden heart risk in cancer patients revealed: 3,153 colorectal/gastric cancer patients, AI-quantified CAC on routine CTs, 9-yr f/u. Result: CAC>400 = 2.3x higher CVD risk. Opportunistic screening that could save lives! #CardioOncology @ChanDrYou https://t.co/wkcDMEdYVv https://t.co/OfavP7BCy9

  • Mashup Score: 2

    BACKGROUND: Although survival for out-of-hospital cardiac arrest (OHCA) is lower at emergency medical service (EMS) agencies serving Black/Hispanic communities, it is unknown whether this is due to practice differences. METHODS: Within the Cardiac Arrest Registry to Enhance Survival (CARES) registry in the United States, we conducted a survey from 2022 to 2023 of resuscitation practices at EMS agencies with ≥10 OHCAs annually between 2015 and 2019. We examined differences in dispatch, first responder, and EMS practices between agencies with majority Black/Hispanic catchment areas (>50% residents Black or Hispanic) and majority White catchment areas using χ2 tests. We estimated each agency’s risk-standardized rate of survival to hospital admission for OHCA using multivariable hierarchical logistic regression and evaluated whether survival differences between the 2 agency groups were attenuated after adjusting for resuscitation practice differences. RESULTS: Among 470 EMS agencies (181 7

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    • Practice differences between agencies with Black/Hispanic and White catchment areas partly account for OHCA survival disparities @saketgirotra @KBreathettMD @saintlukeskc #AHAJournals https://t.co/NnOwnfKvgH https://t.co/XhmOBbJfCi

  • Mashup Score: 8

    Epidemiology is at a critical juncture. In 1996, Frederick H. Epstein, MD, FRCP, posthumously shared that cardiovascular epidemiology should result in a “deepened understanding of the forces that determine individual and group attitudes and behaviors relating to the preservation of health.” 1 Since then, the field has expanded dramatically in methods, analytic approaches, and data resources. Over the past 3 decades, epidemiology has increasingly aligned with disciplines such as quality and outcomes

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    • Read the recent @CircOutcomes Editor's Note📝by @KBreathettMD @emilycob @NorrinaA about the journal's upcoming CV Epidemiology special issue! 📅Submit your work by August 15, 2025 https://t.co/j6rod4fwQm @bnallamo @iamritu

  • Mashup Score: 8

    Epidemiology is at a critical juncture. In 1996, Frederick H. Epstein, MD, FRCP, posthumously shared that cardiovascular epidemiology should result in a “deepened understanding of the forces that determine individual and group attitudes and behaviors relating to the preservation of health.” 1 Since then, the field has expanded dramatically in methods, analytic approaches, and data resources. Over the past 3 decades, epidemiology has increasingly aligned with disciplines such as quality and outcomes

    Tweet Tweets with this article
    • Read the recent @CircOutcomes Editor's Note📝by @KBreathettMD @emilycob @NorrinaA about the journal's upcoming CV Epidemiology special issue! 📅Submit your work by August 15, 2025 https://t.co/j6rod4fwQm @bnallamo @iamritu