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Mashup Score: 22Guideline-Directed Medical Therapy Use in the STRONG-HF Trial | Circulation: Heart Failure - 2 day(s) ago
BACKGROUND: Assessment of medication changes in heart failure trials and registries is complex and may not capture the entirety of care. A comprehensive and standardized method is needed. We used different methods to assess the use of guideline-directed medical therapies (GDMT) and verified the association between GDMT intensity score with the STRONG-HF trial (Safety, Tolerability and Efficacy of Rapid Optimization, Helped by NT-proBNP Testing of Heart Failure Therapies) clinical outcomes. METHODS: We used data from the STRONG-HF trial to examine the baseline GDMT use for all randomized patients by applying the GDMT intensity score and evaluated its change over time. We also examined their basic adherence, indication-corrected adherence, and dose-corrected adherence, and the association with clinical outcomes up to 180 days. RESULTS: At 90 days, triple therapy indication-corrected use increased from 4.5% to 36% in the usual care group, and from 5.2% to 93.5% in the high-intensity care
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Mashup Score: 15Endothelin-1 and Accelerated Cardiac Allograft Vasculopathy After Heart Transplantation | Circulation: Heart Failure - 3 day(s) ago
View all available purchase options and get full access to this article. Lund LH, Edwards LB, Kucheryavaya AY, Benden C, Dipchand AI, Goldfarb S, Levvey BJ, Meiser B, Rossano JW, Yusen RD, et al. The registry of the international society for heart and lung transplantation: thirty-second official adult heart transplantation report–2015; focus theme: early graft failure. J Heart Lung Transplant. 2015;34:1244–1254. doi: 10.1016/j.healun.2015.08.003 Geny B, Piquard F, Lonsdorfer J, Haberey P. Endothelin and
Source: www.ahajournals.orgCategories: General Medicine NewsTweet-
Prospective contemporary data suggest that higher ET-1 levels after HT are associated with accelerated CAV at 1 year @GCFMD @wfearonmd @KiranKhush1 @alinsairmd @DavidTehrani3 @jukakimMD @rushiparikh11 #AHAJournals https://t.co/ZogiQAozbN https://t.co/rW7SYz1pH4
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Mashup Score: 2
BACKGROUND: The prevalence of transthyretin cardiac amyloidosis among older adults (often octogenarians) is increasing. We aimed to determine whether age and geriatric syndromes bear any impact on the management and outcomes in transthyretin cardiac amyloidosis and assess the risk of ageism. METHODS: In a prospective, multicenter cohort study, 256 patients diagnosed with transthyretin cardiac amyloidosis from March 2021 to March 2024 underwent comprehensive geriatric assessment (CGA). The study evaluated the prevalence and clinical associations of CGAs across different disease stages (National Amyloidosis Centre stage). Key CGA domains included disability, malnutrition, depression, frailty, Short Physical Performance Battery, and cumulative deficits (sum of the single CGA items). Associations of these measures with disease-modifying therapy and overall mortality were analyzed. RESULTS: Median age was 82 years (men: n=223 [87%]; variant: n=19 [7.4%]); 129 (50.3%) patients received disea
Source: www.ahajournals.orgCategories: General Medicine NewsTweet-
Prognostic Value of Malnutrition, Frailty, & Physical Performance in Transthyretin Cardiac Amyloidosis: Insights from a Prospective Multicenter Cohort Study @glimongelli @MattBeltrami @IacopoOlivotto @AlessiaArgiro @beamusumeci1 @TiniGiacomo @MathewMaurer https://t.co/GLR9MM09qT https://t.co/n3JkUJkHgd
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Mashup Score: 86Determinants of Right Heart Hemodynamic Derangement in Patients With and Without Tricuspid Regurgitation | Circulation: Heart Failure - 6 day(s) ago
BACKGROUND: The determinants of tricuspid regurgitation (TR) hemodynamic severity remain to be established. We explored the hemodynamic correlates of right atrial (RA) pressure and stroke volume (SV) in patients with and without TR, and assessed the reliability of the indirect Fick method in relation to TR severity. METHODS: In this observational study, right ventricular (RV) 3-dimensional echocardiography (3DE) was obtained simultaneously with direct Fick right heart catheterization. RVSV3DE and SVRHC were combined to determine the TR regurgitant fraction (RegFr=RVSV3DE-RVSVRHC/RVSV3DE). RA pressures and strain (or 3DE volumes) were combined to derive RA compliance. RESULTS: Out of 74 patients, 61% had moderate or severe TR. TR severity was associated with larger right heart chambers, lower RA compliance, higher values and lower inspiratory decrease of RA pressure, and lower cardiac index (P<0.01). In univariate analysis, RA V wave was associated with RegFr (r=−0.57) and with ln-trans
Source: www.ahajournals.orgCategories: General Medicine NewsTweet-
Determinants of Right Heart Hemodynamic Derangement in Patients with and Without Tricuspid Regurgitation @GParati22 @denisamuraru @GodinoCosmo @FudimMarat @a_sorropago @jeanlucvachiery @CaravitaSergio @michetomaselli @lpbadano #AHAJournals https://t.co/bXTCJqa3s7 https://t.co/LdMr0pCdb5
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Mashup Score: 0
BACKGROUND: This study evaluates clinical trends and mid-term waitlist and posttransplant outcomes following the 2018 heart allocation policy change. METHODS: The United Network for Organ Sharing registry was queried to analyze adult waitlisted and transplanted patients undergoing isolated heart transplantation. Two analyses were conducted: (1) waitlist and (2) posttransplant outcomes. For the waitlist analysis, candidates were stratified into seasonally matched prepolicy (October 18, 2012–June 30, 2017) and postpolicy (October 18, 2018–June 30, 2023) groups, with a 1-year follow-up period. Waitlist outcomes included 1-year cumulative incidences of transplantation, delisting due to death/clinical deterioration, and all-cause survival from the initial waitlisting. For the posttransplant analysis, recipients were stratified into seasonally matched prepolicy (October 18, 2014–June 30, 2018) and postpolicy (October 18, 2018–June 30, 2020) groups, with a 4-year follow-up period. Posttranspl
Source: www.ahajournals.orgCategories: General Medicine NewsTweet-
2/ ✅ Similar 4-year post-transplant survival Full UNOS analysis ⬇️ 🔗 https://t.co/kvicmOqmQz #HeartTransplant #HeartFailure #UNOS https://t.co/Q04AyDKTu7
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Mashup Score: 2Eosinophilic Myocarditis in Children From Toxocara Canis: A Case and Review of the Literature | Circulation: Heart Failure - 23 day(s) ago
View all available purchase options and get full access to this article. Shibazaki S, Eguchi S, Endo T, Wakabayashi T, Araki M, Gu Y, Imai T, Asano K, Taniuchi N. Eosinophilic myocarditis due to toxocariasis: not a rare cause. Case Rep Cardiol. 2016;2016:2586292. doi: 10.1155/2016/2586292 Krous HF, Haas E, Chadwick AE, Wagner GN. Sudden death in a neonate with idiopathic eosinophilic endomyocarditis. Pediatr Dev Pathol Off J Soc Pediatr Pathol Paediatr Pathol Soc. 2005;8:587. doi: 10.1007/s10024-005-0042-7
Source: www.ahajournals.orgCategories: General Medicine NewsTweet-
Eosinophilic myocarditis in a child caused by Toxocara canis. Diagnosis via MRI & biopsy; early treatment was lifesaving. #PedsCardio #PedsID @M_OConnorC @HugoMartinezMD @DellMedSchool @Jason_N_Johnson #AHAJournals https://t.co/o5it3L6tl2 https://t.co/4Jz2i1yo2G
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Mashup Score: 6Sex-Related Prognosis of VA-ECMO-Treated Cardiogenic Shock: A Post-Hoc Analysis of the HYPO-ECMO Trial | Circulation: Heart Failure - 23 day(s) ago
Background: The sex-related prognosis of patients with cardiogenic shock (CS) undergoing veno-arterial extracorporeal membrane oxygenation (VA-ECMO) remains unclear. Our analyses aim to assess sex-specific outcomes in patients with CS receiving VA-ECMO and explored whether the effect of moderate hypothermia (MH) on clinical outcomes was modified by sex. Methods: In this post-hoc analysis of the HYPO-ECMO trial, clinical outcomes were compared by sex. The primary outcome was 30-day all-cause mortality (ACM). Key secondary outcomes included ACM and a composite outcome of ACM, heart transplant, escalation to left ventricular assist device implantation, or stroke at 30, 60 and 180 days. Results: Among the 334 patients enrolled in the trial, 81 (24%) were female. At 30 days, 45.7% of female and 46.6% of male patients experienced the primary outcome, with no sex differences (adjusted OR, 1.01 [0.57 – 1.78], p=0.98 and log-rank test, p=0.93). No significant sex differences were observed in al
Source: www.ahajournals.orgCategories: General Medicine NewsTweet-
👉 No difference in outcomes between male and female patients after VA-ECMO for cardiogenic shock: HYPO-ECMO trial findings! @hvanspall @GuiBaudry @NicolasGirerd #AHAJournals https://t.co/CLljwZ0ke7 https://t.co/kbuTlUsAtW
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Mashup Score: 6Impact of Neighborhood Factors on Exercise Capacity in Children With Hypertrophic Cardiomyopathy | Circulation: Heart Failure - 23 day(s) ago
BACKGROUND: Restricting certain patients with hypertrophic cardiomyopathy (HCM) from exercise likely has negative cardiovascular effects and has not been shown to reduce the risk of sudden cardiac death. Promoting exercise in children with HCM is complex and requires knowledge of the environmental factors that impact exercise capacity in children with HCM. METHODS: This retrospective, cross-sectional analysis includes children with HCM who underwent exercise stress testing at a single, children’s tertiary-care center between 2000 and 2023. Addresses from contemporaneous exercise stress testing were accessed and geocoded to census tracts. The child opportunity index was the primary exposure of interest. Granular neighborhood measures including the walkability index, rural-urban commuting area codes, index of concentration at the extremes, and uniform crime reporting rates were measured. The primary outcome measure was peak oxygen consumption. Linear regression and multivariable analyses
Source: www.ahajournals.orgCategories: General Medicine NewsTweet-
In children with hypertrophic cardiomyopathy, their neighborhood and environment impact their peak exercise capacity @DrRossMasood @JonEdwardsMD #AHAJournals https://t.co/FteZ81Jt94 https://t.co/XKIrTUHSfT
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Mashup Score: 4High-Sensitivity Cardiac Troponin I for Risk Stratification in Wild-Type Transthyretin Amyloid Cardiomyopathy | Circulation: Heart Failure - 24 day(s) ago
BACKGROUND: Thresholds to define prognosis with hs-cTnI (high-sensitivity cardiac troponin I) have not been systematically addressed in wild-type transthyretin amyloid cardiomyopathy, in part because of the multiplicity of hs-cTnI assays. The aims of this study were, first, to assess the prognostic performance of hs-cTnI measured with different assays in patients with wild-type transthyretin amyloid cardiomyopathy and, second, to identify assay-specific hs-cTnI thresholds for prognosis that could be integrated into staging systems for risk stratification. METHODS: Observational multicenter study of stable wild-type transthyretin amyloid cardiomyopathy patients from different cohorts using the Abbott Architect Stat hs-cTnI assay and the Beckman Coulter Access hs-cTnI assay (testing cohorts) and the Siemens Centaur XPT hs-cTnI assay (validation cohort). Outcome was all-cause mortality. RESULTS: In the Abbott cohort (n=136; median follow-up, 22 [13–41] months; 31 [23%] deaths) and Beckman
Source: www.ahajournals.orgCategories: General Medicine NewsTweet-
High-Sensitivity Cardiac Troponin I for Risk Stratification in Wild-Type Transthyretin Amyloid Cardiomyopathy @matser89 @aldoporcari @TiniGiacomo @GSaturi @LauraDemichieli @albcipri6 #AHAJournals https://t.co/m4vcT1aFyM https://t.co/bXKQKbtmVt
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Mashup Score: 51| AHA/ASA Journals - 1 month(s) ago
Circulati on: Heart Failure is proud to launch a new and exclusive educational series tailored for current advanced heart failure fellows and early-career attendings (within two years of fellowship completion). This year-long course is designed to: – Expand your clinical knowledge – Facilitate meaningful peer and mentor connections – Provide direct exposure to the editorial and research environment of Circulation: Heart Failure The program includes: – Eight 60-90 minute live, virtual sessions led by
Source: www.ahajournals.orgCategories: General Medicine NewsTweet-
📣Calling all #AHFTC Fellows! @CircHF is proud to launch a free educational webinar series for current or past AHFTC fellows. 📍8 live virtual sessions, 1 in-person event 📍New topic each session 📅Start Date: August 13, 2025 🔗Learn More: https://t.co/sPBjhJimND https://t.co/Pd5pwJrCbJ
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Guideline-Directed Medical Therapy Use in the STRONG-HF Trial @AdriaanVoors @lamcardio @MarcoMetra @justinezekowitz @CVC_UAlberta #AHAJournals https://t.co/KGVju5K7bi https://t.co/BNfRCzjL6g