Trickster microbes, manels, and Venus
A pick of the most compelling Nature feature stories this year.
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Direct interactions between the human insula and hippocampus during memory encoding
Nature Neuroscience – The hippocampus and insula communicate when processing emotional memories. Discrete sites in the human insular cortex showed changes that predicted later memory…
Association of viral RNAs in the choroid plexus with bipolar disorder and schizophrenia and evidence for the hepatitis C virus involvement in neuropathology
Translational Psychiatry – Association of viral RNAs in the choroid plexus with bipolar disorder and schizophrenia and evidence for the hepatitis C virus involvement in…
Mapping trait-associated cells with spatial transcriptomics
Nature Reviews Genetics – Liyang Song presents gsMap, which integrates spatial transcriptomics (ST) data with GWAS summary statistics to assess whether genetic variants in or…
Response of spatially defined microglia states with distinct chromatin accessibility in a mouse model of Alzheimer’s disease
Nature Neuroscience – The dynamics of microglia states adjacent to or far from amyloid-beta plaques are unclear. Here the authors show that non-plaque-associated microglia modulate…
Digital transformation with clinical alerts and personalized care systems in an integrated value based model
npj Digital Medicine – Digital transformation with clinical alerts and personalized care systems in an integrated value based model
Premenstrual disorders and risk of cardiovascular diseases
Nature Cardiovascular Research – Yang et al. draw evidence from population-based and sibling cohort studies to reveal that women suffering from premenstrual disorders are at…
Global Neurodegneration Proteomics Consortium
The Global Neurodegeneration Proteomics Consortium is a multi-national database that aims to leverage proteomics and clinical data to understand and improve …
Disruption of the cerebrospinal fluid–plasma protein balance in cognitive impairment and aging
Nature Medicine – Proteomic analysis of paired cerebrospinal fluid and plasma samples from 2,171 individuals drawn from multiple cohorts, including the Global Neurodegeneration Proteomics…