Wnt‐mediated activation of actin‐binding CaMKII regulates tunneling nanotube formation and transfer of vesicles and pathological protein aggregates between neurons.
imageimageAneuploidy is frequent in cancer, but in vitro it triggers multiple cellular stresses and often delays proliferation. Through integrative proteogenomic analysis of evolved aneuploid cell…
imageimageThis study presents an integrated RNA-seq and ChIP-seq analysis after in vivo whole-body radiation of isogenically matched mouse strains. Mutant 172H p53 is shown to…
imageimageMicrobe-derived indoles modulate anxiety and neuronal excitability in the amygdala of germ-free (GF) male mice. These findings demonstrate a molecular mechanism by which microbes tune…
imageimageThe risk variant rs57141087 is predominant in Black women and modulates TRIM37 levels through enhancer-promoter interactions. TRIM37 overexpression in early stages promotes neoplastic transformations, accelerates…
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imageimageAging diminishes autophagy in short-lived model organisms. This study uncouples macroautophagy and mitophagy in the aging mouse brain at the single-cell level in vivo by…
Mitochondria appear to communicate and cooperate with one another, both within and between cells. Biologists are only just beginning to understand how and why.
imageimageThe Leismhania membrane protein KMP-11 facilitates parasite invasion into macrophages through cholesterol transport from the macrophage membrane to Leishmania and subsequent phase transition in the…
Background In patients with colorectal cancer (CRC), the therapeutic effects of conventional immune checkpoint inhibitors targeting the adaptive immune system are largely limited to those…
Why are young people getting cancer at higher rates? No one knows, but here’s how to stay proactive and vigilant.
