The scientific events that shaped the decade
The 2010s have seen breakthroughs in frontiers from gene editing to gravitational waves. The coming one must focus on climate change.
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A multi-kingdom genetic barcoding system for precise clone isolation
Nature Biotechnology – A barcoded CRISPR base editing system isolates target clones from complex mammalian, yeast and bacterial populations.
Evolution, spread and impact of highly pathogenic H5 avian influenza A viruses
Nature Reviews Microbiology – In this Review, Fouchier and colleagues explore the evolution, spread and zoonotic risks of highly pathogenic H5 avian influenza viruses. They…
Closed-loop vagus nerve stimulation aids recovery from spinal cord injury
Nature – Following spinal cord injury, gamified physical therapy that incorporates closed-loop vagus nerve stimulation can aid restoration of arm and hand function.
Stereopsis in the Infant Aphakia Treatment Study: outcome at 10½ years
Eye – Stereopsis in the Infant Aphakia Treatment Study: outcome at 10½ years
Large language models are proficient in solving and creating emotional intelligence tests
Communications Psychology – Six Large Language Models outperformed humans on five ability emotional intelligence tests. ChatGPT-4 also successfully generated new test items for each test,…
Effects of KCNQ potassium channel modulation on ventral tegmental area activity and connectivity in individuals with depression and anhedonia
Molecular Psychiatry – Effects of KCNQ potassium channel modulation on ventral tegmental area activity and connectivity in individuals with depression and anhedonia
Clonal tracing with somatic epimutations reveals dynamics of blood ageing
Nature – The discovery that DNA methylation of different CpG sites can serve as digital barcodes of clonal identity led to the development of EPI-Clone,…
Synapse vulnerability and resilience across the clinical spectrum of dementias
Nature Reviews Neurology – In this Review, Taddei and Duff consider the concepts of synapse vulnerability and resilience, and how an understanding of the mechanisms…
PCSK9 drives sterol-dependent metastatic organ choice in pancreatic cancer
Nature – PCSK9 regulates low density lipoprotein-cholesterol import and determines organ preference of metastatic pancreatic ductal adenocarcinoma, with PCSK9-low cells metastasizing to the liver…
Microglia activation orchestrates CXCL10-mediated CD8+ T cell recruitment to promote aging-related white matter degeneration
Nature Neuroscience – White matter aging leads to degenerative and inflammatory changes. Here the authors show that microglial dysfunction exacerbates glial CXCL10 expression, harmful CD8+…
