The neurexin gene family regulates olfactory glomerular formation
How neural circuits establish precise connectivity remains unclear. Park et al. demonstrate that differentially expressed neurexin isoforms in olfactory sensory neurons (OSNs) direct axon sorting to specific glomeruli through transsynaptic interactions with distinct ligands, including neuroligin1, on mitral/tufted (M/T) cells. This finding suggests a novel role for neurexins during brain development to ensure accurate circuit assembly in the mammalian olfactory bulb.
